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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Toppari, Jorma / Turan, Serap Demircioglu


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

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2191-0251
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Volume 32, Issue 10

Issues

Zinc deficiency in Japanese children with idiopathic short stature

Kei Yoshida / Tatsuhiko Urakami / Remi Kuwabara / Ichiro Morioka
Published Online: 2019-08-24 | DOI: https://doi.org/10.1515/jpem-2019-0129

Abstract

Background and methods

We investigated the frequency of zinc deficiency in Japanese children with idiopathic short stature, and evaluated whether serum zinc levels correlated with background factors, including age and standard deviation scores (SDSs) for height and serum insulin-like growth factor (IGF)-1 levels. The study subjects consisted of 89 Japanese children.

Results

The mean serum zinc level was 79 ± 12 (49–108) μg/dL. Of all the children, 48.3% had a low zinc level, in the 60–80 μg/dL range, and 6.7% had zinc deficiency with a zinc level below 60 μg/dL. The majority with a low zinc level and zinc deficiency were asymptomatic other than for short stature. We found no significant correlations of serum zinc with age, or the SDSs for height and serum IGF-1 levels, in either the entire subject population or those with a zinc level below 80 μg/dL.

Conclusions

We found a low zinc level to be common in Japanese children with idiopathic short stature, whereas actual zinc deficiency was rare. However, other as yet unknown mechanisms not associated with the growth hormone (GH)-IGF-1 axis could be involved in growth retardation in idiopathic short stature.

Keywords: children; idiopathic short stature; insulin-like growth factor-1 (IGF-1); Japanese; serum zinc level; zinc deficiency

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About the article

Corresponding author: Tatsuhiko Urakami, MD, Department of Pediatrics and Child Health, Nihon University School of Medicine, 1-6 Kandasurugadai, Chiyoda-ku, Tokyo, Japan, Phone: +81-3-3293-1711, Fax: +81-3-3292-2880


Received: 2019-03-21

Accepted: 2019-07-05

Published Online: 2019-08-24

Published in Print: 2019-10-25


Author contributions: K.Y. and U.T. designed the study; K. Y. and R. K. collected clinical samples; K.Y. performed the statistical analysis and drafted the manuscript; T.U. and I. M. critically revised the manuscript. All authors read and approved the final manuscript.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 32, Issue 10, Pages 1083–1087, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2019-0129.

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