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Licensed Unlicensed Requires Authentication Published by De Gruyter November 12, 2019

Associations between thyroid-stimulating hormone, blood pressure and adiponectin are attenuated in children and adolescents with overweight or obesity

  • Alberte Drivsholm , Morten Asp Vonsild Lund ORCID logo EMAIL logo , Paula L. Hedley , Thomas Jespersen , Michael Christiansen , Torben Hansen and Jens-Christian Holm

Abstract

Background

The association between thyroid-stimulating hormone (TSH) concentrations and blood pressure is well described in adults, but only studied to a limited extent in children and adolescents and almost entirely in population-based cohorts. The present study investigates the association between TSH and blood pressure, and the influence of leptin and adiponectin, in a cohort of children and adolescents enrolled in obesity treatment compared with a population-based cohort.

Methods

We studied 4154 children and adolescents aged 6–18 years from an obesity clinic cohort and a population-based cohort from The Danish Childhood Obesity Data- and Biobank. Anthropometrics, blood pressure and biochemical markers, including TSH, leptin and adiponectin concentrations, were collected. Adjusted correlation and interaction analyses were performed.

Results

Patients from the obesity clinic cohort exhibited higher concentrations of TSH and higher blood pressure than participants from the population-based cohort. TSH standard deviation scores (SDS) were significantly associated with all blood pressure-related variables in the population-based cohort, but only with systolic blood pressure SDS and hypertension in the obesity clinic cohort. The interaction between TSH SDS and adiponectin was found to be independently associated with systolic blood pressure and hypertension in the population-based cohort only.

Conclusions

The significant associations between TSH, adiponectin and blood pressure, observed in children and adolescents from a population-based cohort, are attenuated or absent in children and adolescents with overweight or obesity, suggesting that childhood obesity distorts the healthy interplay between the thyroid axis, thyroid-adipokine interaction and blood pressure.


Corresponding author: Morten Asp Vonsild Lund, MD, The Children’s Obesity Clinic, European Centre of Management (EASO), Department of Paediatrics, Copenhagen University Hospital Holbæk, DK-4300 Holbæk, Denmark; and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, Phone: 0045-59 48 42 00
aAlberte Drivsholm and Morten Asp Vonsild Lund contributed equally to this work, and share the first authorship.

Acknowledgements

This study is part of the research activities in TARGET (The Impact of our Genomes on Individual Treatment Response in Obese Children), BIOCHILD (Genetics and Systems Biology of Childhood Obesity in India and Denmark), and MicrobLiver (www.sdu.dk/en/flash/projects/microbliver). The study is part of The Danish Childhood Obesity Data- and Biobank; ClinicalTrials.gov ID-no.: NCT00928473, registered June 25th 2009. The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent Research Center at the University of Copenhagen partially funded by an unrestricted donation from the Novo Nordisk Foundation. This research has been conducted using the Danish National Biobank resource, supported by the Novo Nordisk Foundation. The authors wish to thank Mrs. Pia Lind, Mrs. Oda Troest and Mrs. Birgitte Holløse for their invaluable assistance with blood samples and database. The authors also wish to thank the Department of Clinical Biochemistry at Copenhagen University Hospital Holbæk.

  1. Author contributions: AD, MAVL, PLH, TJ, MC, TH and JH designed the research. AD, MAVL and JH conducted the data collection. AD and MAVL performed the literature search, analysed the data and generated the tables and figures and wrote the paper draft. All authors contributed to the interpretation of data and critical revision of the manuscript, and approved the final manuscript.

  2. Research funding: This study received funding from the Innovation Fund Denmark (grant numbers 0603-00484B (TARGET) and 0603-00457B (BIOCHILD)) and the Novo Nordisk Foundation (grant number NNF15OC0016544 and NNF15OC0016692 (MicrobLiver)). AD is supported by a grant from The Danish Council for Independent Research. MAVL is supported by a grant from The Danish Heart Foundation (18-R125-A8447).

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

  6. Conflict of interest: JH received lecture fees from Novo Nordisk and is the owner of Dr Holm Ltd, which provides medical services, training and supervision. All other authors have nothing to disclose.

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Received: 2019-08-06
Accepted: 2019-09-11
Published Online: 2019-11-12
Published in Print: 2019-12-18

©2019 Walter de Gruyter GmbH, Berlin/Boston

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