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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma

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Volume 32, Issue 7


Auditory event-related potentials demonstrate early cognitive impairment in children with subclinical hypothyroidism

Sibel Kocaaslan Atli
  • Corresponding author
  • İzmir Katip Çelebi University, Faculty of Medicine, Department of Biophysics, İzmir, Turkey
  • Email
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  • De Gruyter OnlineGoogle Scholar
/ Nihal Olgaç Dündar
  • İzmir Katip Çelebi University, Faculty of Medicine, Department of Pediatric Neurology, Izmir, Turkey
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/ Onur Bayazit / Nur Evirgen Esin / Uğraş Erdoğan
  • Izmir Institute of Technology, Faculty of Engineering, Department of Electrical – Electronics, Izmir, Turkey
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/ Gönül Çatli
  • Izmir Katip Celebi University, Faculty of Medicine, Department of Pediatric Endocrinology, Izmir, Turkey
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/ Mehmet Cemal Kahya
  • İzmir Katip Çelebi University, Faculty of Medicine, Department of Biophysics, İzmir, Turkey
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  • De Gruyter OnlineGoogle Scholar
/ Bumin Nuri Dündar
  • Izmir Katip Celebi University, Faculty of Medicine, Department of Pediatric Endocrinology, Izmir, Turkey
  • Other articles by this author:
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Published Online: 2019-06-11 | DOI: https://doi.org/10.1515/jpem-2018-0463



The aim of this study was to examine the cognitive functions of children with subclinical hypothyroidism (SH) and healthy children with the use of auditory event-related potentials (AERPs) and neuropsychological tests.


Twenty children aged between 8 and 17 years, diagnosed with SH, and 20 age-matched healthy controls were included in this study. A classical auditory oddball paradigm was applied during the electroencephalography (EEG) recordings, and event-related potentials (ERPs) were evaluated between the 0.5- and 20-Hz frequency intervals. P1, N1, P2, N2 and P3 amplitudes and latencies were measured in Fz, FCz, Cz, CPz, Pz and Oz electrodes. Additionally, a number of neuropsychological tests evaluating the reaction time and various cognitive functions were carried out.


In children with SH, P3 amplitudes in FCz, Cz and CPz electrodes were significantly lower than those in controls (p < 0.05). In addition to this, the P1N1 and N1P2 peak-to-peak amplitude values were also found to be smaller for children with SH than controls (p < 0.05). With regard to the neuropsychological tests, no significant difference was observed between the SH and control groups on any of the cognitive test parameters, reaction time or correct response rates.


In the present study, while children with SH did not differ from controls with respect to their cognitive functions evaluated via neuropsychological tests, cognitive differences were detected via electrophysiological investigations. This result implies that implicit changes in cognition which are not yet overtly reflected on neuropsychological tests may be detected at an early stage in children with SH.

Keywords: auditory event-related potentials; children; cognitive functions; subclinical hypothyroidism


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About the article

Corresponding author: Asst. Prof. Dr. Sibel Kocaaslan Atli, PhD, İzmir Katip Çelebi University, Faculty of Medicine, Department of Biophysics, İzmir, Turkey, Phone: (+90) 530 500 5832

Received: 2018-10-24

Accepted: 2019-04-15

Published Online: 2019-06-11

Published in Print: 2019-07-26

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 32, Issue 7, Pages 689–697, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2018-0463.

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