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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma

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Volume 32, Issue 9


Association of the 3′UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity

Alan Joel Ruiz-Padilla
  • Department of Pharmacy, Natural and Exact Sciences Division, University of Guanajuato, Guanajuato Campus, Guanajuato, Gto, Mexico
  • Other articles by this author:
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/ Gerardo Morales-Hernandez / Yeniley Ruiz-Noa
  • Department of Medical Sciences, Health Sciences Division, University of Guanajuato, Leon Campus, León, Mexico
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/ Angel Josabad Alonso-Castro
  • Department of Pharmacy, Natural and Exact Sciences Division, University of Guanajuato, Guanajuato Campus, Guanajuato, Gto, Mexico
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/ Maria Luisa Lazo-de-la-Vega-Monroy
  • Department of Medical Sciences, Health Sciences Division, University of Guanajuato, Leon Campus, León, Mexico
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/ Monica del Carmen Preciado-Puga
  • Department of Medicine and Nutrition, Health Sciences Division, University of Guanajuato, Leon Campus, León, Gto, Mexico
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/ Ruben Rangel-Salazar
  • Department of Medical Sciences, Health Sciences Division, University of Guanajuato, Leon Campus, León, Mexico
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/ Lorena del Rocio Ibarra-Reynoso
  • Corresponding author
  • Department of Medical Sciences, Health Sciences Division, University of Guanajuato, Leon Campus, León, Mexico
  • Email
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Published Online: 2019-07-16 | DOI: https://doi.org/10.1515/jpem-2018-0546



Fibroblast growth factor 21 (FGF21) is considered an important regulator of lipid and glucose metabolism. However, the role of FGF21 in macronutrient intake and metabolic disease, particularly in pediatric population, still needs further clarification. This study aimed to evaluate the association of rs11665896 in the FGF21 gene with metabolic status and macronutrient intake in a cohort of Mexican children with obesity.


Eighty-four lean children and 113 children with obesity, from 8 to 11 years of age, were recruited. FGF21 rs11665896 was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Somatometric evaluations, nutrient intake, glucose, lipids, insulin and FGF21 serum levels were measured in the obesity group.


The T allele of rs11665896 in the FGF21 gene was associated with obesity (odds ratio [OR] = 1.99, 95% confidence interval [CI] = 1.14–3.46; p = 0.0151). Subjects with obesity carrying the TT genotype consumed less lipids and more carbohydrates compared to other genotypes. Circulating FGF21 levels correlated negatively with carbohydrate intake (r = −0.232, p = 0.022) and positively with body weight (r = 0.269, p = 0.007), waist (r = 0.242, p = 0.016) and hip girth (r = 0.204, p = 0.042). FGF21 levels were lower in carriers of at least one T allele.


Genetic variants in FGF21 could influence metabolic status, food preferences and qualitative changes in nutritional behavior in children.

Keywords: FGF21; genetic variants; nutrient intake; obesity


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About the article

Corresponding author: Lorena del Rocio Ibarra-Reynoso, MD, PhD, Department of Medical Sciences, Health Sciences Division, University of Guanajuato, Leon Campus, 20 de enero 929, Obregón, León, Gto, CP 37320, Mexico, Phone: +(52)4772674900

aAlan Joel Ruiz-Padilla and Gerardo Morales-Hernandez contributed equally to the realization of this work and share the first authorship.

Received: 2018-12-10

Accepted: 2019-05-18

Published Online: 2019-07-16

Published in Print: 2019-09-25

Author contributions: A.J.R.P. and G.M.H. contributed to data collection, experimental execution, literature search and generation of figures and tables; Y.R.N. and M.L.L.d.l.V.M. wrote the manuscript and performed the statistical analysis; A.J.A.C. and M.d.C.P.P. contributed to data interpretation and performed the statistical analysis; R.R.S. contributed to experimental analysis and data acquisition; L.d.R.I.R. contributed to the study design, wrote the manuscript and reviewed/edited the manuscript. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: This study was supported by a grant from the Secretary of Public Education of Mexico (PRODEP-SEP UGTO-PTC-439).

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: None declared.

Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 32, Issue 9, Pages 921–928, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2018-0546.

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