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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

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Volume 27, Issue 11-12

Issues

The DATAC study: a new growth database. Description of the epidemiology, diagnosis and therapeutic attitude in a group of Spanish children with short stature

María Dolores Rodríguez Arnao / Amparo Rodríguez Sánchez / César García-Rey / Francisco Javier Arroyo Díez / Ramón Cañete Estrada / Beatriz García Cuartero / María Alija Merillas / Juan P. López-Siguero on behalf of the DATAC study group
Published Online: 2014-09-11 | DOI: https://doi.org/10.1515/jpem-2013-0394

Abstract

Background: Recombinant human growth hormone (rhGH) availability has allowed the treatment of a greater number of growth disorders. It is important to get an insight into the clinical characteristics of the paediatric population before rhGH treatment.

Methods: An observational, retrospective and multicentre study was conducted to evaluate the patients’ baseline characteristics prior to rhGH therapy.

Results: A total of 1404 patients (53.8% males) aged 0.5–17.3 years were included. Clinical conditions were as follows: GH deficiency (GHD), 66.0%; small for gestational age (SGA), 29.7%; and Turner syndrome (TS), 4.3%. Male gender was predominant in most growth disorders; age at diagnosis was higher in GHD patients; therapy with rhGH started at lower chronological age in SGA and TS groups.

Conclusion: The baseline characteristics of the population to be treated with rhGH were similar to those reported in other growth databases. Delayed age at treatment initiation should increase the awareness of these disorders among general paediatricians and entice them to refer children suspected of having these disorders to a specialist.

Keywords: growth disorders; growth hormone; growth hormone deficiency; small for gestational age; Turner syndrome

References

  • 1.

    Cook DM, Rose SR. A review of guidelines for use of growth hormone in pediatric and transition patients. Pituitary 2012;15:301–10.PubMedWeb of ScienceCrossrefGoogle Scholar

  • 2.

    Oostdijk W, Grote FK, de Muinck Keizer-Schrama SM, Wit JM. Diagnostic approach in children with short stature. Horm Res 2009;72:202–17.Google Scholar

  • 3.

    Allen DB, Cutler L. Short stature in childhood. Challenges and choices. N Engl J Med 2013;368:1220–8.Web of ScienceGoogle Scholar

  • 4.

    Franklin SL, Geffner ME. Growth hormone: the expansion of available products and indications. Pediatr Clin North Am 2011;58:1141–65.Web of SciencePubMedCrossrefGoogle Scholar

  • 5.

    Pozo J, Martos-Moreno GA, Barrios V, Argente J. The IGF system in childhood: physiology and clinical implications. J Endocrinol Invest 2005;28:38–42.PubMedGoogle Scholar

  • 6.

    Wilson TA, Rose SR, Cohen P, Rogol AD, Backeljauw P, et al. Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. J Pediatr 2003;143:415–21.Google Scholar

  • 7.

    Boguszewski MC, Mericq V, Bergada I, Damiani D, Belgorosky A, et al. Latin American consensus: children born small for gestational age. BMC Pediatr 2011;11:66.Web of ScienceCrossrefPubMedGoogle Scholar

  • 8.

    Clayton PE, Cianfarani S, Czernichow P, Johannsson G, Rapaport R, et al. Management of the child born small for gestational age through to adulthood: a consensus statement of the international societies of pediatric endocrinology and the growth hormone research society. J Clin Endocrinol Metab 2007;92:804–10.Web of ScienceCrossrefGoogle Scholar

  • 9.

    Gharib H, Cook DM, Saenger PH, Bengtsson BA, Feld S, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for growth hormone use in adults and children – 2003 update. Endocr Pract 2003;9:64–76.Google Scholar

  • 10.

    Ranke M. KIGS: 20 years. Horm Res 2007;68:40–4.CrossrefGoogle Scholar

  • 11.

    Carrascosa A, Audi L, Fernandez–Cancio M, Yeste D, Gussinye M, et al. Growth hormone secretory status evaluated by growth hormone peak after two pharmacological growth hormone release stimuli did not significantly influence the two-year catch-up growth induced by growth hormone therapy in 318 prepubertal short children with idiopathic growth retardation. Horm Res Paediatr 2011;75:106–14.Web of ScienceGoogle Scholar

  • 12.

    Sobradillo B, Aguirre A, Aresti. U, Bilbao A, Fernández-Ramos C, et al. Curvas y tablas de crecimiento. Estudios longitudinal y transversal. Bilbao: Fundación Faustino Orbegozo 2004. Available at: http://www.slideshare.net/Karlatareas/tablas-orbegozo1.

  • 13.

    Greulich WW, Pyle SI. Radiographic atlas of skeletal development of the hand and wrist, 2nd ed. Standford, CA, USA: Standford University Press, 1959.Google Scholar

  • 14.

    Bayley N, Pinneau SR. Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr 1952;40:423–41.PubMedCrossrefGoogle Scholar

  • 15.

    Flor-Cisneros A, Roemmich JN, Rogol AD, Baron J. Bone age and onset of puberty in normal boys. Mol Cell Endocrinol 2006;254–255:202–6.Google Scholar

  • 16.

    Argente J, Barrios V, Pozo J, Munoz MT, Hervas F, et al. Normative data for insulin-like growth factors (IGFs), IGF-binding proteins, and growth hormone-binding protein in a healthy Spanish pediatric population: Age- and sex-related changes. J Clin Endocrinol Metab 1993;77:1522–8.Google Scholar

  • 17.

    Elmlinger MW, Kuhnel W, Weber MM, Ranke MB. Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFbp-3). Clin Chem Lab Med 2004;42:654–64.PubMedGoogle Scholar

  • 18.

    Reiter EO, Blethen SL, Baptista J, Price L. Early initiation of growth hormone treatment allows age-appropriate estrogen use in Turner’s syndrome. J Clin Endocrinol Metab 2001;86:1936–41.Google Scholar

  • 19.

    van Pareren YK, de Muinck Keizer-Schrama SM, Stijnen T, Sas TC, Jansen M, et al. Final height in girls with Turner syndrome after long-term growth hormone treatment in three dosages and low dose estrogens. J Clin Endocrinol Metab 2003;88:1119–25.CrossrefGoogle Scholar

  • 20.

    Gandrud LM, Wilson DM. Is growth hormone stimulation testing in children still appropriate? Growth Horm IGF Res 2004;14:185–94.CrossrefPubMedGoogle Scholar

  • 21.

    Hughes IP, Harris M, Choong CS, Ambler G, Cutfield W, et al. Growth hormone regimens in Australia: analysis of the first 3 years of treatment for idiopathic growth hormone deficiency and idiopathic short stature. Clin Endocrinol (Oxf) 2012;77:62–71.Web of ScienceCrossrefGoogle Scholar

  • 22.

    Audi L, Llopis MA, Granada ML, Hermoso F, del Valle J, et al. Low sensitivity of IGF-1, IGFBP-3 and urinary GH in the diagnosis of growth hormone insufficiency in slowly-growing short-statured boys. Grupo Español de Estudio de la Talla Baja. Med Clin (Barc) 2001;116:6–11.Google Scholar

  • 23.

    Savage MO, Burren CP, Rosenfeld RG. The continuum of growth hormone-IGF-1 axis defects causing short stature: diagnostic and therapeutic challenges. Clin Endocrinol (Oxf) 2010;72:721–8.Google Scholar

  • 24.

    Hughes IP, Choong CS, Cotterill A, Harris M, Davies PS. Gender bias in children receiving growth hormone treatment. J Clin Endocrinol Metab 2010;95: 1191–8.CrossrefPubMedGoogle Scholar

  • 25.

    Wilson TA, Rose SR, Cohen P, Rogol AD, Backeljauw P, et al. Update of guidelines for the use of growth hormone in children: The Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. J Pediatr 2003;143:415–21.Google Scholar

About the article

Corresponding author: María Dolores Rodríguez Arnao, MD., Paediatric Endocrinology Unit, University Hospital Gregorio Marañón C/ Doctor Esquerdo, 46., 28007 Madrid, Spain, Phone: +34-91529 0118, E-mail:

aMembers of the DATAC study group are listed in alphabetical order in the Acknowledgements section.


Received: 2013-10-08

Accepted: 2014-07-03

Published Online: 2014-09-11

Published in Print: 2014-11-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 27, Issue 11-12, Pages 1201–1208, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2013-0394.

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