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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma

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Volume 29, Issue 11


Increased levels of bisphenol A (BPA) in Thai girls with precocious puberty

Vichit Supornsilchai
  • Corresponding author
  • Division of Endocrinology, Faculty of Medicine, Department of Pediatrics, Chulalongkorn University, Bangkok, Thailand
  • Email
  • Other articles by this author:
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/ Chutima Jantarat / Wichit Nosoognoen / Sopon Pornkunwilai
  • Division of Endocrinology, Faculty of Medicine, Department of Pediatrics, Chulalongkorn University, Bangkok, Thailand
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Suttipong Wacharasindhu
  • Division of Endocrinology, Faculty of Medicine, Department of Pediatrics, Chulalongkorn University, Bangkok, Thailand
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/ Olle Soder
  • Department of Women’s and Children’s Health, Karolinska Institute and University Hospital, Stockholm, Sweden
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-01-21 | DOI: https://doi.org/10.1515/jpem-2015-0326



Reports on the secular trend of pubertal onset indicate a recent earlier start especially in girls. Bisphenol A (BPA), which posses estrogenic activity, might be a cause of advanced puberty. The objective of the study was to determine the association between BPA and advanced puberty.


A cross-sectional study was conducted in patients with advanced puberty (n=41) compared to age-matched controls (n=47). Anthropometric measurements, estradiol, basal and gonadotropin releasing hormone (GnRH)-stimulated follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels, uterine sizes, ovarian diameters and bone ages were obtained. Urinary BPA concentrations were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC/MSMS) with the lower limit of quantification (LLOQ) of 0.05 ng/mL.


The median adjust-BPA concentration in advanced puberty group was higher than in control groups [1.44 vs. 0.59 μg/g creatinine (Cr): p<0.05]. We also found that the median adjust-BPA concentration in girls with advanced puberty who were overweight/obese, was greater than in the normal pubertal overweight/obese girls (1.74 vs. 0.59 μg/g Cr: p<0.05), and was in the same trend among normal weight girls with advanced and normal puberty (0.83 vs. 0.49 μg/g Cr: p=0.09), but not statistically significant.


The present findings suggest that BPA exposure appears to be related to an earlier age at onset of puberty especially in obese girls.

Keywords: advanced puberty; bisphenol A; early puberty; obesity; overweight; precocious puberty; UPLC-MS/MS


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About the article

Corresponding author: Vichit Supornsilchai, MD, PhD, Division of Endocrinology, Faculty of Medicine, Department of Pediatrics, Sor Kor Building 11th floor, Chulalongkorn University Hospital, Bangkok 10330, Thailand, Phone: +662-256-4989, Fax: +662-256-4911

Received: 2015-08-14

Accepted: 2015-11-19

Published Online: 2016-01-21

Published in Print: 2016-11-01

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: Professor Olle Soder was financially supported by the Swedish Research Council. This study was funded by the Thailand Research Fund (Grant No. MRG5580203).

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 29, Issue 11, Pages 1233–1239, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2015-0326.

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