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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Ogata, Tsutomu / Toppari, Jorma

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2191-0251
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Vitamin D status in Israeli pediatric type 1 diabetes patients: the AWeSoMe Study Group experience and literature review

Judith Brody / Orit Pinhas-Hamiel
  • Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
  • Pediatric Endocrine and Diabetes Unit, Safra Children’s Hospital, Sheba Medical Center, Tel-Hashomer, Israel
  • Juvenile Diabetes Center, Maccabi Health Care Services, Raanana, Israel
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Zohar Landau
  • Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
  • Juvenile Diabetes Center, Maccabi Health Care Services, Raanana, Israel
  • Pediatric Diabetes Service, Wolfson Medical Center, Holon, Israel
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Adi Adar
  • Pediatric Endocrinology Service, Division of Pediatrics, Assaf Harofeh Medical Center, Sackler School of Medicine, Tel Aviv University, Zerifin, Israel
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Tzvy Bistritzer
  • Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
  • Pediatric Endocrinology Service, Division of Pediatrics, Assaf Harofeh Medical Center, Sackler School of Medicine, Tel Aviv University, Zerifin, Israel
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marianna Rachmiel
  • Corresponding author
  • Pediatric endocrinology and Diabetes Unit, Assaf Harofeh Medical Center, Zerifin 70300, Israel
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-10-19 | DOI: https://doi.org/10.1515/jpem-2016-0137

Abstract

Background:

The prevalence of both vitamin D (VitD) deficiency and type 1 diabetes mellitus (T1DM) has increased worldwide over the last few decades. The objectives of this study were: (1) to evaluate the prevalence of VitD deficiency and insufficiency among Israeli youth with T1DM and (2) to assess the association between VitD status, seasonality and T1D glycemic control characteristics.

Methods:

This was a multi-centered, cross-sectional study. VitD levels were routinely tested during the years 2008–2011 in T1DM patients aged up to 21 years. Medical records were reviewed for demographic, clinical and laboratory characteristics.

Results:

The study population consisted of 199 participants (53% males), mean age 12.24±4.11 years, mean T1DM duration 3.77±3.43 years. VitD levels were within the normal range in 19.6%, insufficient (15–29 ng/mL, 37–72 nmol/L) in 62.3% and deficient (<15 ng/mL, <37 nmol/L) in 18.1%. Mean VitD level was higher during the summer than during spring, autumn and winter (28.65 ng/mL, 23.16 ng/mL, 21.65 ng/mL, 17.55 ng/mL, respectively, p<0.001). Mean VitD level was higher among secular patients compared to the religious (whole-year heavily dressed) population (23.57 ng/mL, 15.54 ng/mL, respectively, p<0.001). VitD level was negatively associated with body mass index calculation of standard deviation scores (BMI-SDS), high-density lipoprotein (HDL) and age at diagnosis (r=−0.171, p=0.016; r=−0.149, p=0.043; r=−0.150, p=0.037, respectively). No association was demonstrated with disease duration and glycemic control indices and metabolic parameters.

Conclusions:

VitD insufficiency is largely prevalent among Israeli youth with T1DM, as is in Israeli youth in general. The VitD level is associated with seasonality, clothing habits and BMI.

Keywords: glycemic control; type 1 diabetes mellitus; vitamin D

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About the article

Corresponding author: Marianna Rachmiel, MD, Director, Pediatric endocrinology and Diabetes Unit, Assaf Harofeh Medical Center, Zerifin 70300, Israel, Phone: 972-8-9542007, Fax: 972-8-9779136


Received: 2016-04-06

Accepted: 2016-08-29

Published Online: 2016-10-19


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Pediatric Endocrinology and Metabolism, 20160137, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2016-0137.

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