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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma

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Volume 29, Issue 11


Association between the triglyceride to high-density lipoprotein cholesterol ratio and insulin resistance in Korean adolescents: a nationwide population-based study

Jae-Min Park
  • Department of Family Medicine, Konkuk University Medical Center, Seoul, Korea (Republic of)
  • Department of Medicine, Graduate School, Yonsei University, Seoul, Korea (Republic of)
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/ Jee-Yon Lee
  • Department of Family Medicine, CHA University College of Medicine, Chaum Life Center, CHA Bundang Medical center, Korea (Republic of)
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/ Jae June Dong
  • Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea (Republic of)
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/ Duk-Chul Lee
  • Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea (Republic of)
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/ Yong-Jae Lee
  • Corresponding author
  • Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea (Republic of)
  • Email
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-10-14 | DOI: https://doi.org/10.1515/jpem-2016-0244



Studies have suggested the triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) as a surrogate marker of insulin resistance. However, few studies have examined the association between TG/HDL-C and insulin resistance in the general adolescent population. This study aimed to examine the association between TG/HDL-C and insulin resistance in a nationally representative sample of Korean adolescents.


A total of 2649 participants aged 12–18 years were selected from the 2007 to 2010 Korean National Health and Nutrition Examination Survey (KNHANES). Insulin resistance was defined as the homeostatic model assessment of insulin resistance (HOMA-IR) values greater than the 80th percentile.


The mean values of most cardiometabolic variables increased proportionally with TG/HDL-C quartiles. Compared to individuals in the lowest TG/HDL-C quartile, the odds ratio for insulin resistance for individuals in the highest quartile was 2.91 in boys and 2.38 in girls after adjusting for confounding variables.


This study suggests that TG/HDL-C could be a convenient marker for identifying Korean adolescents with insulin resistance.

Keywords: adolescents; HOMA-IR; insulin resistance; triglyceride to high-density lipoprotein cholesterol ratio


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About the article

Corresponding author: Yong-Jae Lee, MD, MPH, PhD, Associate Professor Department of Family Medicine, Yonsei University College of Medicine Gangnam Severance Hospital, 211 Eonju-ro, Gangnam-gu, Seoul 135-720, Republic of Korea, Phone: +82 2 2019 2630, Cell: +82 10 7292 9169, Fax: +82 3462 8209

Received: 2016-06-17

Accepted: 2016-08-29

Published Online: 2016-10-14

Published in Print: 2016-11-01

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 29, Issue 11, Pages 1259–1265, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2016-0244.

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