Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica

IMPACT FACTOR 2018: 1.361
5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

SCImago Journal Rank (SJR) 2018: 0.522
Source Normalized Impact per Paper (SNIP) 2018: 0.602

See all formats and pricing
More options …
Volume 27, Issue 1


Antibiotics: Treatment of preterm labor

T. Reimer / N. Ulfig / K. Friese
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/JPM.1999.004


Our intention is to review recent data and provide recommendations for the use of antibiotics in cases of preterm labor or preterm premature rupture of the membranes (pPROM). Various studies assessing antibiotics as treatment for preterm labor demonstrate neonatal or maternal benefits only in certain circumstances. Antibiotic treatment should be given to patients with bacterial vaginosis and Trichomonas vaginalis. Currently, antibiotics should not be applied routinely to prolong pregnancy in women with preterm labor and intact membranes. However, antibiotic therapy should be given to patients with pPROM to prolong pregnancies at 24 to 32 weeks' gestation. Our management of pPROM up to 32 weeks' gestation includes use of corticosteroids, antibiotic (extended spectrum penicillins) and tocolytic treatment for preterm labor and pregnancy prolongation. We consider expectant management previous to evidence of intrauterine infection. In women with pPROM at 32 to 34 weeks we found it beneficial to deliver 24 hours after administration of corticosteroids or, in cases of intrauterine infection, immediately. Finally, we report on our research work regarding fetal brain development in preterm birth. Further studies will be necessary to clarify the role of the interleukin-6/interleukin-6 receptor pathway in the development of intracerebral hemorrhage frequently occuring in premature infants.

About the article

Published Online: 2005-06-01

Published in Print: 1999-03-01

Citation Information: Journal of Perinatal Medicine, Volume 27, Issue 1, Pages 35–40, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.1999.004.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Natalia de Miguel, Gil Lustig, Olivia Twu, Arnab Chattopadhyay, James A. Wohlschlegel, and Patricia J. Johnson
Molecular & Cellular Proteomics, 2010, Volume 9, Number 7, Page 1554
Prashini Moodley and A.Willem Sturm
Seminars in Neonatology, 2000, Volume 5, Number 3, Page 255
Patricia Sauer Witcher
The Journal of Perinatal & Neonatal Nursing, 2002, Volume 16, Number 1, Page 25
H.M Tanir, T Sener, N Tekin, A Aksit, and N Ardic
International Journal of Gynecology & Obstetrics, 2003, Volume 82, Number 2, Page 167
Iain L. O. Buxton, Windee Crow, and Shaji O. Mathew
AACN Clinical Issues: Advanced Practice in Acute & Critical Care, 2000, Volume 11, Number 2, Page 271
Cheryl Y. M. Okumura, Linda G. Baum, and Patricia J. Johnson
Cellular Microbiology, 2008, Volume 10, Number 10, Page 2078

Comments (0)

Please log in or register to comment.
Log in