Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto

9 Issues per year


IMPACT FACTOR 2017: 1.558
5-year IMPACT FACTOR: 1.653

CiteScore 2017: 1.26

SCImago Journal Rank (SJR) 2017: 0.594
Source Normalized Impact per Paper (SNIP) 2017: 0.684

Online
ISSN
1619-3997
See all formats and pricing
More options …
Volume 29, Issue 2

Issues

Effect of positive end expiratory pressure on functional residual capacity and compliance in surfactant-treated preterm infants

Jürgen Dinger / Andreas Töpfer / Peter Schaller / Roland Schwarze
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/JPM.2001.018

Abstract

Positive end expiratory pressure is routinely used when ventilating preterm infants. Elevation of PEEP increases lung volume, as does surfactant treatment. The purpose of this study was to investigate the effect of various levels of PEEP within the range of 0.2 to 0.4 kPa on lung volume, compliance and gas exchange. We measured functional residual capacity, compliance of the respiratory system and arterial blood gases in 20 infants (median birth weight 1240 g, range 660–1690 g; median gestational age 28 weeks, range 24–32 weeks; postnatal age 3–4 days). The infants were studied at 72 hours after their last dose of natural surfactant. At this time the patients were routinely nursed at 0.3 kPa of PEEP, the PEEP level was lowered to 0.2 kPa or raised to 0.4 kPa in random order. The PEEP level was then changed to the third level 0.4 kPa or 0.2 kPa. Each new setting was maintained for 20 min before FRC, compliance and blood gases were measured. FRC was assessed using SF6 washout technique.

Increasing PEEP from 0.2 to 0.3 to 0.4 kPa resulted in increases in FRC (p < 0.01) and oxygenation (ns) in all infants. In 16 infants compliance decreased and paCO2 increased with elevation of PEEP. Only in 4 infants compliance increased and CO2 fell.

Conclusion: In the majority of our infants reduction of PEEP from 0.4 to 0.2 kPa resulted in increases in compliance and CO2 reduction. Our results might suggest that relatively low levels of PEEP < 0.3 kPa may be appropriate at 72 hours after surfactant replacement. Furthermore, these results underline the importance of PEEP test in clinical practice.

About the article

Published Online: 2005-06-01

Published in Print: 2001-04-05


Citation Information: Journal of Perinatal Medicine, Volume 29, Issue 2, Pages 137–143, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2001.018.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
David Guevorkian, Sebastien Mur, Eric Cavatorta, Laurence Pognon, Thameur Rakza, and Laurent Storme
The Journal of Pediatrics, 2018
[2]
Risha Bhatia, Peter G. Davis, and David G. Tingay
The Journal of Pediatrics, 2017, Volume 187, Page 80
[3]
Julia C. Hartung, Silke Wilitzki, Marta Thio-Lluch, Arjan B. te Pas, Gerd Schmalisch, Charles C. Roehr, and Edgardo Szyld
PLOS ONE, 2016, Volume 11, Number 2, Page e0150224
[4]
Marcus J. Kitchen, Melissa L. Siew, Megan J. Wallace, Andreas Fouras, Robert A. Lewis, Naoto Yagi, Kentaro Uesugi, Arjan B. te Pas, Stuart B. Hooper, and Edgardo Szyld
PLoS ONE, 2014, Volume 9, Number 4, Page e93391
[5]
F. Reiterer, E. Sivieri, and S. Abbasi
Pediatric Pulmonology, 2015, Volume 50, Number 10, Page 1039
[6]
Cindy T. McEvoy and Judy L. Aschner
Clinics in Perinatology, 2015, Volume 42, Number 4, Page 911
[7]
Yoginder Singh and Sam Oddie
Resuscitation, 2013, Volume 84, Number 11, Page 1558
[8]
J.C. Hartung, A.B. te Pas, H. Fischer, G. Schmalisch, and C.C. Roehr
Neonatology, 2012, Volume 102, Number 3, Page 190
[9]
Chantelle Mann, Carole Ward, Mark Grubb, Barrie Hayes-Gill, John Crowe, Neil Marlow, and Don Sharkey
Resuscitation, 2012, Volume 83, Number 5, Page 607
[10]
Megan E Probyn, Stuart B Hooper, Peter A Dargaville, Naomi McCallion, Kelly Crossley, Richard Harding, and Colin J Morley
Pediatric Research, 2004, Volume 56, Number 2, Page 198
[11]
Kelly J Crossley, Colin J Morley, Beth J Allison, Graeme R Polglase, Peter A Dargaville, Richard Harding, and Stuart B Hooper
Pediatric Research, 2007, Volume 62, Number 1, Page 37
[12]
[13]
Peter C. Rimensberger
Current Opinion in Pediatrics, 2002, Volume 14, Number 3, Page 315
[14]
Stuart B Hooper, Marcus J Kitchen, Melissa LL Siew, Robert A Lewis, Andreas Fouras, Arjan B te Pas, Karen KW Siu, Naoto Yagi, Kentaro Uesugi, and Megan J Wallace
Clinical and Experimental Pharmacology and Physiology, 2009, Volume 36, Number 1, Page 117
[15]
Ximena Alegría, Nelson Claure, Yoshirou Wada, Cristian Esquer, Carmen D'Ugard, and Eduardo Bancalari
Pediatric Pulmonology, 2006, Volume 41, Number 8, Page 759
[16]
Hans Proquitté, Ariane Kusztrich, Volker Auwärter, Fritz Pragst, Roland R. Wauer, and Gerd Schmalisch
Critical Care Medicine, 2006, Volume 34, Number 6, Page 1789
[17]
Monika Gappa, J. Jane Pillow, Julian Allen, Oscar Mayer, and Janet Stocks
Pediatric Pulmonology, 2006, Volume 41, Number 4, Page 291
[18]
Georg Hülskamp, J. Jane Pillow, Jürgen Dinger, and Janet Stocks
Pediatric Pulmonology, 2006, Volume 41, Number 1, Page 1
[19]
CPF O'Donnell, PG Davis, and CJ Morley
Journal of Paediatrics and Child Health, 2004, Volume 40, Number 4, Page 208

Comments (0)

Please log in or register to comment.
Log in