Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


IMPACT FACTOR 2018: 1.361
5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

SCImago Journal Rank (SJR) 2018: 0.522
Source Normalized Impact per Paper (SNIP) 2018: 0.602

Online
ISSN
1619-3997
See all formats and pricing
More options …
Volume 29, Issue 4

Issues

Patent ductus arteriosus in very low birthweight infants: complications of pharmacological and surgical treatment

Petra S. Koehne / Georg Bein / Vladimir Alexi-Meskhishvili / Yuguo Weng / Christoph Bührer / Michael Obladen
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/JPM.2001.047

Abstract

Aims: To evaluate complications of surgical and pharmacological treatment of symptomatic patent ductus arteriosus (PDA) in very low birthweight (VLBW) infants.

Patients and methods: Of 931 VLBW infants consecutively admitted 1987–1998, a significant PDA prompted first-choice treatment by indomethacin in 101 infants, and surgery in 55 infants. PDA closed or became asymptomatic after indomethacin in 64 patients (63 %), while 34 went on to surgery. PDA closure was achieved in all 61 infants after ligation and in 26 of 28 infants after clipping.

Results: Transient renal impairment after indomethacin treatment was recorded in 40 of 101 infants (40 %), compared to renal impairment in 9 of 55 infants (16 %) undergoing surgery without prior indomethacin. No differences in necrotizing enterocolitis and intracranial hemorrhage rates were seen. Air leak occurred in 6 of 89 infants after surgery, two of which had fatal tension pneumothorax. Intraoperative hemorrhage requiring emergency transfusion occurred in 2 infants, wound infection occurred in 2 infants and phrenic palsy in one infant. Based on an intention-to-treat analysis, the overall fatality rates were 16 of 101 (16 %) for indomethacin and 14 of 55 (25 %) for surgery.

Conclusions: Despite the short-comings inherent to retrospective analyses, we propose that surgery should be reserved for infants not responding to pharmacological PDA closure.

About the article

Published Online: 2005-06-01

Published in Print: 2001-08-29


Citation Information: Journal of Perinatal Medicine, Volume 29, Issue 4, Pages 327–334, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2001.047.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Sophie Malekzadeh‐Milani, Ahmad Akhavi, Stéphanie Douchin, Claire Dauphin, Aurélie Chalard, Pierre Mauran, Hélène Bouvaist, Damien Bonnet, and Younes Boudjemline
Catheterization and Cardiovascular Interventions, 2019
[2]
YoungAh Youn, Yu-mi Seo, Sook-Kyung Yum, and In Kyung Sung
Italian Journal of Pediatrics, 2019, Volume 45, Number 1
[3]
Sok-Leng Kang, Salehuddin Samsudin, Minju Kuruvilla, Anshoo Dhelaria, Sue Kent, and Wilfred A. Kelsall
Cardiology in the Young, 2013, Volume 23, Number 5, Page 711
[4]
Shyam Sathanandam, Hitesh Agrawal, Sandeep Chilakala, Jason Johnson, Kimberly Allen, Christopher Knott-Craig, B. Rush Waller, and Ranjit Philip
Congenital Heart Disease, 2019, Volume 14, Number 1, Page 79
[5]
Adam Willis, Lillia Pereiras, Tim Head, Genevieve Dupuis, Janet Sessums, Gordon Corder, Kim Graves, Jack Tipton, and Shyam Sathanandam
Congenital Heart Disease, 2019, Volume 14, Number 1, Page 69
[6]
Hitesh Agrawal, Benjamin Rush Waller, Sushitha Surendan, and Shyam Sathanandam
Interventional Cardiology Clinics, 2019, Volume 8, Number 1, Page 23
[7]
Shyam Sathanandam, Kaitlin Balduf, Sandeep Chilakala, Kristen Washington, Kimberly Allen, Christopher Knott-Craig, Benjamin Rush Waller, and Ranjit Philip
Catheterization and Cardiovascular Interventions, 2018
[9]
Donough J O'Donovan, Arlina Baetiong, Karen Adams, Ann Chen, E O'Brian Smith, James M Adams, and Leonard E Weisman
Journal of Perinatology, 2003, Volume 23, Number 4, Page 286
[10]
Bernard Thébaud and Thierry Lacaze-Mazmonteil
Paediatrics & Child Health, 2010, Volume 15, Number 5, Page 267
[11]
YoungAh Youn, Cheong-Jun Moon, Jae-Young Lee, Cheul Lee, and In Kyung Sung
Medicine, 2017, Volume 96, Number 14, Page e6557
[12]
Gregory P Moore, Sarah L Lawrence, Gyaandeo Maharajh, Amanda Sumner, Isabelle Gaboury, Nick Barrowman, and Brigitte Lemyre
Paediatrics & Child Health, 2012, Volume 17, Number 4, Page e26
[13]
Gideon Koren, Ana Florescu, Adriana Moldovan Costei, Radinka Boskovic, and Myla E Moretti
Annals of Pharmacotherapy, 2006, Volume 40, Number 5, Page 824
[14]
William C. Spanos, James T. Brookes, Mark C. Smith, Harold M. Burkhart, Edward F. Bell, and Richard J. H. Smith
Annals of Otology, Rhinology & Laryngology, 2009, Volume 118, Number 10, Page 750
[15]
Evan M. Zahn, Daniel Peck, Alistair Phillips, Phillip Nevin, Kaylan Basaker, Charles Simmons, Marion E. McRae, Tracy Early, and Ruchira Garg
JACC: Cardiovascular Interventions, 2016, Volume 9, Number 23, Page 2429
[16]
Shyam Sathanandam, Henri Justino, B. Rush Waller, Wolfgang Radtke, and Athar M. Qureshi
Catheterization and Cardiovascular Interventions, 2017, Volume 89, Number 6, Page 1051
[17]
Filomena Valentina Paradiso, Elena Jane Mason, Riccardo Marano, and Lorenzo Nanni
Journal of Pediatric Surgery Case Reports, 2016, Volume 10, Page 17
[18]
Evan M. Zahn, Phillip Nevin, Charles Simmons, and Ruchira Garg
Catheterization and Cardiovascular Interventions, 2015, Volume 85, Number 2, Page 240
[19]
Jun Ho Lee, Sun Kyun Ro, Hyun Ju Lee, Hyun Kyung Park, Won-Sang Chung, Young Hak Kim, Jeong Ho Kang, and Hyuck Kim
The Korean Journal of Thoracic and Cardiovascular Surgery, 2014, Volume 47, Number 5, Page 444
[20]
S. Schubert, B. Opgen-Rhein, P. Ewert, K. Schmitt, C.P. Schubert, S. Assa, and F. Berger
Monatsschrift Kinderheilkunde, 2014, Volume 162, Number 9, Page 798
[21]
Han Kyul Kim, In Su Choi, Hwa Jin Cho, Eun Song Song, Young Kuk Cho, Young Earl Choi, Young Youn Choi, and Jae Sook Ma
Korean Journal of Perinatology, 2013, Volume 24, Number 4, Page 237
[22]
Young-Ah Youn, Cheong-Jun Moon, So-Young Kim, Jae Young Lee, and In-Kyung Sung
Pediatric Cardiology, 2014, Volume 35, Number 5, Page 793
[23]
Yun Hee Chang, Jae Young Lee, Jeong Eun Kim, Ji-yong Kim, YoungAh Youn, Eun-Jung Lee, Sena Moon, Ju Young Lee, and In Kyung Sung
The Annals of Thoracic Surgery, 2013, Volume 96, Number 3, Page 879
[24]
Seong-Min Ko, Young Chul Yoon, Kwang-Hyun Cho, Yang-Haeng Lee, Il-Yong Han, Kyung-Taek Park, Yoon Ho Hwang, and Hee Jae Jun
The Korean Journal of Thoracic and Cardiovascular Surgery, 2013, Volume 46, Number 3, Page 178
[25]
YoungAh Youn, Ju-Young Lee, Jung Hyun Lee, So-Young Kim, In Kyung Sung, and Jae Young Lee
Early Human Development, 2013, Volume 89, Number 3, Page 175
[26]
Kai-Hsiang Hsu, Ming-Chou Chiang, Reyin Lien, Jaw-Ji Chu, Yu-Sheng Chang, Shih-Ming Chu, Kin-Sun Wong, and Peng-Hong Yang
European Journal of Pediatrics, 2012, Volume 171, Number 11, Page 1639
[27]
Ozgur Olukman, Sebnem Calkavur, Gulten Ercan, Fusun Atlihan, Taliha Oner, Vedide Tavli, and Nilgun Kultursay
Congenital Heart Disease, 2012, Volume 7, Number 6, Page 534
[28]
Olachi J. Mezu-Ndubuisi, Ghanshyam Agarwal, Aarti Raghavan, Jennifer T. Pham, Kirsten H. Ohler, and Akhil Maheshwari
Drugs, 2012, Volume 72, Number 7, Page 907
[29]
Marion Arnold and Samuel W. Moore
Journal of Pediatric Surgery, 2012, Volume 47, Number 4, Page 665
[31]
Arvind Sehgal and Patrick J. McNamara
Seminars in Perinatology, 2012, Volume 36, Number 2, Page 105
[32]
Melinda Markham
Newborn and Infant Nursing Reviews, 2006, Volume 6, Number 3, Page 151
[33]
S.G. Golombek, A. Sola, H. Baquero, D. Borbonet, F. Cabañas, C. Fajardo, G. Goldsmit, L. Lemus, E. Miura, A. Pellicer, J.M. Pérez, M. Rogido, G. Zambosco, and B. van Overmeire
Anales de Pediatría, 2008, Volume 69, Number 5, Page 454
[34]
Chien-Chou Hsiao, Jen-Tien Wung, Lon-Yen Tsao, and Weng-Cheng Chang
Journal of the Formosan Medical Association, 2009, Volume 108, Number 1, Page 72
[35]
Bernard Thébaud, Xi-Chen Wu, Hidemi Kajimoto, Sandra Bonnet, Kyoko Hashimoto, Evangelos D Michelakis, and Stephen L Archer
Pediatric Research, 2008, Volume 63, Number 2, Page 176
[36]
Amish Jain, Mohit Sahni, Afif El-Khuffash, Emad Khadawardi, Arvind Sehgal, and Patrick J. McNamara
The Journal of Pediatrics, 2012, Volume 160, Number 4, Page 584
[37]
C. Rheinlaender, D. Helfenstein, C. Pees, E. Walch, C. Czernik, M. Obladen, and P. Koehne
Early Human Development, 2010, Volume 86, Number 2, Page 87
[38]
Christiane Pees, Elisabeth Walch, Michael Obladen, and Petra Koehne
Early Human Development, 2010, Volume 86, Number 8, Page 503
[39]
Frederick Alexander, Louisa Chiu, Matthew Kroh, Jeffrey Hammel, and John Moore
Journal of Pediatric Surgery, 2009, Volume 44, Number 1, Page 112
[40]
Nandkishor S. Kabra, Barbara Schmidt, Robin S. Roberts, Lex W. Doyle, Luann Papile, and Avroy Fanaroff
The Journal of Pediatrics, 2007, Volume 150, Number 3, Page 229
[41]
Wolfgang Pumberger, Markus Mayr, Christine Kohlhauser, and Manfred Weninger
Journal of the American College of Surgeons, 2002, Volume 195, Number 6, Page 796
[42]
Lars Garten, Angela Salm, Jochen Rosenfeld, Elisabeth Walch, Christoph Bührer, and Dieter Hüseman
European Journal of Pediatrics, 2011, Volume 170, Number 4, Page 469
[43]
M.-C. Chiang, W.-S. Lin, R. Lien, and Y.-H. Chou
Journal of Perinatal Medicine, 2004, Volume 32, Number 4
[44]
S Harling, I Hansen-Pupp, A Baigi, and E Pesonen
Acta Paediatrica, 2011, Volume 100, Number 2, Page 231
[45]
F G Ramos, C R Rosenfeld, L Roy, J Koch, and C Ramaciotti
Journal of Perinatology, 2010, Volume 30, Number 8, Page 535
[46]
Hyun Ju Lee, Gyu Hong Sim, Kyung Eun Jung, Jin A Lee, Chang Won Choi, Ee Kyung Kim, Han Suk Kim, Beyong Il Kim, and Jung-Hwan Choi
Korean Journal of Pediatrics, 2008, Volume 51, Number 10, Page 1065
[47]
Andrew C. Glatz, Christopher J. Petit, and Matthew J. Gillespie
Catheterization and Cardiovascular Interventions, 2008
[49]
Linh G. Ly, Judith Hawes, Hilary E. Whyte, Lilian S. Teixeira, and Patrick J. McNamara
Neonatology, 2006, Volume 91, Number 4, Page 260
[50]
Matthew M Laughon, Michael A Simmons, and Carl L Bose
Current Opinion in Pediatrics, 2004, Volume 16, Number 2, Page 146
[52]
PATRIZIA ZARAMELLA, FEDERICA FREATO, VALENTINA QUARESIMA, MARCO FERRARI, MARCO BARTOCCI, MAURIZIO RUBINO, ELENA FALCON, and LINO CHIANDETTI
Pediatrics International, 2006, Volume 48, Number 3, Page 305
[53]
John L Morris, David A Rosen, and Kathleen R Rosen
Pediatric Drugs, 2003, Volume 5, Number 6, Page 385
[54]
John L Morris, David A Rosen, and Kathleen R Rosen
Pediatric Drugs, 2003, Volume 5, Number 6, Page 385
[55]
T. Tan, N. Mizobe, H. Sugiyama, Y. Maeda, A. Naitou, K. Kodera, T. Sato, and S. Nakazawa
Pediatric Cardiology, 2005, Volume 26, Number 6, Page 801
[56]
Toshiro KOBAYASHI, Kenji HAYASHI, Kensuke SAKATA, and Yurio KOBAYASHI
Yamaguchi Medical Journal, 2004, Volume 53, Number 6, Page 291

Comments (0)

Please log in or register to comment.
Log in