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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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Tissue concentrations of cytokines in the lower uterine segment during preterm parturition

M. Winkler / B. Kemp / D.-C. Fischer / H. Maul / M. Hlubek / W. Rath
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/JPM.2001.072


Aims: To determine the concentrations of tumor necrosis factor α, interleukin-1β, interleukin-6, and interleukinin the lower uterine segment during preterm parturition. Methods: In 71 patients who delivered prematurely nonelective cesarean tissue specimens were obtained from the lower uterine segment. The patients were grouped in relation to the stage of cervical dilatation (< 2 cm, 2–< 4 cm, ≥ 4 cm), duration of labor (≤ 6h, > 6–12 h; > 12 h), and parity (1 versus > 1). Cytokine concentrations in protein extracts of the tissue samples were measured using enzyme-linked immunosorbent assays. Results: Median concentration of tumor necrosis factor α did not change, but that of interleukin-1β, interleukin-6, and interleukin-8 were significantly higher at 2–< 4 cm than at < 2 cm cervical dilatation (6.6, 67.7, and 125.8 versus 1.1, 17.6, and 22.2 pg/mg protein, respectively). The concentrations of interleukin-6 and interleukin-8 showed a further increase at ≥ 4 cm (297.2 and 468.6 pg/mg, respectively), but for interleukin 1β a decrease was observed (0.6 pg/mg). Cytokine concentrations were not related to duration of labor or parity. Conclusions: Local inflammationassociated changes that are mainly related to the stage of cervical dilatation and to only a minor degree to uterine activity may play a crucial role in preterm parturition.

Published Online: 2005-06-01

Published in Print: 2001-11-27

Citation Information: Journal of Perinatal Medicine. Volume 29, Issue 6, Pages 519–527, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2001.072, June 2005

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