Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica

IMPACT FACTOR 2018: 1.361
5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

SCImago Journal Rank (SJR) 2018: 0.522
Source Normalized Impact per Paper (SNIP) 2018: 0.602

See all formats and pricing
More options …
Volume 31, Issue 2


Impaired CD14-dependent and independent response of polymorphonuclear leukocytes in preterm infants

P. Henneke / I. Osmers / K. Bauer / N. Lamping / H. T. Versmold / R. R. Schumann
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/JPM.2003.024


Preterm newborn infants are especially susceptible to Gram-negative sepsis that is associated with a lethality of up to 40%.

Aims: We tested whether polymorphonuclear leukocytes (PMN) from preterm infants exhibit an impaired antibacterial response upon stimulation with lipopolysaccharide (LPS) from Escherichia coli when compared to full term newborns or adults.

Methods: We studied the effect of LPS on the expression of the surface proteins CD11b and CD14 and the secretion of elastase by PMN from preterm infants, term infants and adults ex vivo.

Results: We found a significantly reduced antibacterial activity of PMN from preterm infants upon stimulation with LPS as indicated by low surface expression of the adhesion molecule CD11b and the reduced secretion of PMN elastase. LPS-induced CD11b expression was dependent on binding of LPS to the surface protein CD14 as CD14 antibodies inhibited LPS dependent CD11b upregulation. Furthermore CD14 expression was lower on PMN from preterm infants than from adults. In addition, CD14 independent upregulation of CD11b in response to tumor necrosis factor (TNF-α), N-formyl peptides (FMLP) and phorbol ester (PMA) was impaired.

Conclusion: PMN from preterm infants are distinctly hyporesponsive to LPS, which may explain the predisposition of these children to invasive disease due to gramnegative bacteria.

About the article

Published Online: 2005-06-01

Published in Print: 2003-03-31

Citation Information: Journal of Perinatal Medicine, Volume 31, Issue 2, Pages 176–183, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2003.024.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Philipp Henneke, Siegfried Morath, Satoshi Uematsu, Stefan Weichert, Markus Pfitzenmaier, Osamu Takeuchi, Andrea Müller, Claire Poyart, Shizuo Akira, Reinhard Berner, Giuseppe Teti, Armin Geyer, Thomas Hartung, Patrick Trieu-Cuot, Dennis L. Kasper, and Douglas T. Golenbock
The Journal of Immunology, 2005, Volume 174, Number 10, Page 6449
Sybille Kenzel, Guiseppe Mancuso, Richard Malley, Guiseppe Teti, Douglas T. Golenbock, and Philipp Henneke
The Journal of Immunology, 2006, Volume 176, Number 5, Page 3181
Nicolas W.J. Schröder and Ralf R. Schumann
Journal of Endotoxin Research, 2005, Volume 11, Number 4, Page 237
Nardhy Gomez-Lopez, Roberto Romero, Valeria Garcia-Flores, Yi Xu, Yaozhu Leng, Ali Alhousseini, Sonia S. Hassan, and Bogdan Panaitescu
American Journal of Reproductive Immunology, 2017, Page e12723
F. Urlichs and C. P. Speer
NeoReviews, 2004, Volume 5, Number 10, Page e417
S. Chandra, H. Haines, C. Michie, and A. Maheshwari
NeoReviews, 2007, Volume 8, Number 9, Page e368
Kirsten Glaser and Christian P Speer
Expert Review of Clinical Immunology, 2013, Volume 9, Number 12, Page 1239
M. Sperandio, E. J. Quackenbush, N. Sushkova, J. Altstatter, C. Nussbaum, S. Schmid, M. Pruenster, A. Kurz, A. Margraf, A. Steppner, N. Schweiger, L. Borsig, I. Boros, N. Krajewski, O. Genzel-Boroviczeny, U. Jeschke, D. Frommhold, and U. H. von Andrian
Blood, 2013, Volume 121, Number 21, Page e118
Ashish Arunkumar Sharma, Roger Jen, Alison Butler, and Pascal M. Lavoie
Clinical Immunology, 2012, Volume 145, Number 1, Page 61
Mohammad Ariful Islam, Mehmet Ulas Cinar, Muhammad Jasim Uddin, Ernst Tholen, Dawit Tesfaye, Christian Looft, and Karl Schellander
Veterinary Immunology and Immunopathology, 2012, Volume 146, Number 1, Page 62
Eva Levy, Georgina Xanthou, Eftichia Petrakou, Vassiliki Zacharioudaki, Christos Tsatsanis, Spyros Fotopoulos, and Marietta Xanthou
Pediatric Research, 2009, Volume 66, Number 2, Page 179
Valerie Le Rouzic, Jennifer Corona, and Heping Zhou
Inflammation, 2011, Volume 34, Number 6, Page 576
Digna R. Velez, Stephen Fortunato, Poul Thorsen, Salvatore J. Lombardi, Scott M. Williams, and Ramkumar Menon
American Journal of Obstetrics and Gynecology, 2009, Volume 200, Number 2, Page 209.e1
Philipp Henneke and Reinhard Berner
Seminars in Fetal and Neonatal Medicine, 2006, Volume 11, Number 5, Page 333
Athanasios Filias, Georgios L Theodorou, Sofia Mouzopoulou, Anastasia A Varvarigou, Stephanos Mantagos, and Marina Karakantza
BMC Pediatrics, 2011, Volume 11, Number 1
Andres Ortega, Viren Jadeja, and Heping Zhou
Inflammation Research, 2011, Volume 60, Number 2, Page 175
Sally A. Madsen-Bouterse, Roberto Romero, Adi L. Tarca, Juan Pedro Kusanovic, Jimmy Espinoza, Chong Jai Kim, Jung-Sun Kim, Samuel S. Edwin, Ricardo Gomez, and Sorin Draghici
American Journal of Reproductive Immunology, 2009, Volume 63, Number 1, Page 73
E. J. Molloy, A. J. O'Neill, J. J. Grantham-Sloan, D. W. Webb, and R. W. G. Watson
Clinical & Experimental Immunology, 2007, Volume 151, Number 2, Page 244
Sybille Kenzel and Philipp Henneke
Current Opinion in Infectious Diseases, 2006, Volume 19, Number 3, Page 264
C. C. Yost, M. J. Cody, E. S. Harris, N. L. Thornton, A. M. McInturff, M. L. Martinez, N. B. Chandler, C. K. Rodesch, K. H. Albertine, C. A. Petti, A. S. Weyrich, and G. A. Zimmerman
Blood, 2009, Volume 113, Number 25, Page 6419
Eleanor J. Molloy, Amanda J. O’Neill, Belinda T. Doyle, Julie J. Grantham, Cormac T. Taylor, Margaret Sheridan-Pereira, John M. Fitzpatrick, David W. Webb, and R. William G. Watson
Neonatology, 2006, Volume 90, Number 1, Page 34

Comments (0)

Please log in or register to comment.
Log in