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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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The effect of glucocorticoid therapy on prevention of early neonatal complications in preterm delivery

E.O.S. Madarek / M. Seidhejazie / N. Najati

Citation Information: Journal of Perinatal Medicine. Volume 31, Issue 5, Pages 441–443, ISSN (Print) 0300-5577, DOI: 10.1515/JPM.2003.069, June 2005

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Aim: Premature birth is the single largest cause of perinatal mortality and morbidity in non-anomalous infants in all developed nations. The aim of this study is to survey the role of glucocorticoid therapy in decreasing early neonatal complications in preterm delivery.

Methods: A case control study was carried out on 300 preterm labors.Half the women received one to four 6 mg doses of dexamethasone every 6 hours, depending on the interval between admission and delivery. Neonatal complications were compared between the two groups.

Results: Corticosteroid therapy was observed to have the greatest effect in preventing respiratory distress and neonatal mortality between 29–34 gestational weeks. There was a significant relationship between antenatal corticosteroid therapy interval and mortality of preterm neonates. Complications such as respiratory distress, sepsis, pneumonia, and hyperbilirubinemia were significantly lower in the case group than in the control.

Conclusion: It is recommended that all women at high risk for preterm labor before 35 gestational weeks be given glucocorticoid at least 24 hours before delivery in order to markedly reduce neonatal mortality and morbidity.

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