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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica

IMPACT FACTOR 2017: 1.558
5-year IMPACT FACTOR: 1.653

CiteScore 2017: 1.26

SCImago Journal Rank (SJR) 2017: 0.594
Source Normalized Impact per Paper (SNIP) 2017: 0.684

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Volume 31, Issue 6


Effect of fetal macrosomia on human placental glucose transport and utilization in insulin-treated gestational diabetes

R. G. King / D. T. D. Osmond / S. P. Brennecke / N. M. Gude
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/JPM.2003.073


The aim of this study was to compare glucose transport and utilization in human placentae from pregnancies affected by insulin-treated GDM with and without macrosomia, and from non-diabetic control pregnancies.

Placental lobules were perfused for 4 h. Maternal D-glucose concentration was 4, 8, 16, or 24 mM while the fetal D-glucose was maintained at 3mM. 14C-D-glucose and 3H-L-glucose were infused into the maternal circulation. Radioactivity, D-glucose and L-lactate levels were measured in the fetal and maternal effluent perfusates.

Glucose uptake from the maternal perfusate, and transfer to the fetal effluent were not significantly different between groups. Insulin-treated GDM group without macrosomia had reduced glucose utilization compared to the control group while the insulin-treated GDM group with macrosomia did not. Lactate release into the fetal effluent was significantly reduced in both insulintreated GDM groups compared to the control group.

In conclusion, placental glucose utilization is different between insulin-treated GDM placentae with and without fetal macrosomia.

About the article

Published Online: 2005-06-01

Published in Print: 2003-11-20

Citation Information: Journal of Perinatal Medicine, Volume 31, Issue 6, Pages 475–483, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2003.073.

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