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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year


IMPACT FACTOR 2016: 1.577
5-year IMPACT FACTOR: 1.705

CiteScore 2016: 1.49

SCImago Journal Rank (SJR) 2015: 0.829
Source Normalized Impact per Paper (SNIP) 2015: 0.808

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ISSN
1619-3997
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In This Section
Volume 31, Issue 6 (Nov 2003)

Issues

Does the thrifty phenotype result from chronic glutamate intoxication? A hypothesis

M. Hermanussen / J. A. F. Tresguerres
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/JPM.2003.075

Abstract

The thrifty phenotype hypothesis proposes that the epidemiological associations between poor fetal and infant growth and the subsequent development of the metabolic syndrome, result from the effects of poor nutrition in early life. The present review however, considers an opposite explanation. We hypothesize that fetal over-nutrition plays a major role in the development of the metabolic syndrome. We found evidence that the thrifty phenotype may be the consequence of fetal hyperglutamatemia.

Maternal glutamate (GLU) reaches the fetal circulation, as part of the materno-fetal glutamine-glutamate exchange. Glutamine is absorbed from the maternal circulation, and deaminated for nitrogen utilization, resulting in a fetal production of GLU. GLU is extracted as it returns to the placenta. When the umbilical plasma flow is low, GLU may be trapped in the fetal circulation, and reaches neurotoxic levels. Administering GLU to newborn rodents completely destructs arcuate nucleus neurons, and results in permanently elevated plasma leptin levels that fail to adequately counter-regulate food intake.

Chronic fetal exposure to elevated levels of GLU may be caused by chronic maternal over-nutrition or by reduced umbilical plasma flow. We strongly suggest abandoning the flavoring agent monosodium glutamate and reconsidering the recommended daily allowances of protein and amino acids during pregnancy.

About the article

Published Online: 2005-06-01

Published in Print: 2003-11-20



Citation Information: Journal of Perinatal Medicine, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2003.075. Export Citation

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[1]
Phillipa J. Hay and Angélica M. Claudino
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[2]
Alberto M. Davalli, Carla Perego, and Franco B. Folli
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[4]
D. Farley, M.E. Tejero, A.G. Comuzzie, P.B. Higgins, L. Cox, S.L. Werner, S.L. Jenkins, C. Li, J. Choi, E.J. Dick, G.B. Hubbard, P. Frost, D.J. Dudley, B. Ballesteros, G. Wu, P.W. Nathanielsz, and N.E. Schlabritz-Loutsevitch
Placenta, 2009, Volume 30, Number 9, Page 752
[5]
M. Hermanussen, M. Sunder, M. Voigt, and J.A.F. Tresguerres
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[6]
M. Hermanussen and J. A. F. Tresguerres
Acta Paediatrica, 2007, Volume 94, Number 1, Page 16
[7]
Ka He, Martha L. Daviglus, and Jeremiah Stamler
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[8]
Ka He, Liancheng Zhao, Martha L. Daviglus, Alan R. Dyer, Linda Van Horn, Daniel Garside, Liguang Zhu, Dongshuang Guo, Yangfeng Wu, Beifan Zhou, and Jeremiah Stamler
Obesity, 2008, Volume 16, Number 8, Page 1875
[9]
M Hermanussen, A P García, M Sunder, M Voigt, V Salazar, and J A F Tresguerres
European Journal of Clinical Nutrition, 2006, Volume 60, Number 1, Page 25
[10]
M. Hermanussen and J. Tresguerres
Acta Paediatrica, 2005, Volume 94, Number 1, Page 16

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