Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Editorial Board: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Reiss, Irwin / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year


IMPACT FACTOR 2016: 1.577
5-year IMPACT FACTOR: 1.705

CiteScore 2016: 1.49

SCImago Journal Rank (SJR) 2016: 0.602
Source Normalized Impact per Paper (SNIP) 2016: 0.832

Online
ISSN
1619-3997
See all formats and pricing
More options …
Volume 32, Issue 1

Issues

Intratracheal albumin reduces interleukin-8 in tracheobronchial aspirates in piglets after meconium aspiration

P. A. Tølløfsrud / S. Medbø / A. B. Solås / B. Robertson / C. P. Speer / S. Seidenspinner / C. A. Drevon / O. D. Saugstad
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/JPM.2004.015

Abstract

Meconium aspiration induces pulmonary inflammation and reduces surfactant function. We hypothesized that albumin mixed with meconium attenuates pulmonary inflammation and improves surfactant function after meconium aspiration. We measured the concentration of free fatty acids (FFA) in the meconium (110 mg dry weight/mL) and added albumin to provide a molar FFA:albumin ratio of 1:1. Newborn piglets, 0-2 day of age, artificially ventilated and exposed to hypoxemia by ventilation with 8% O[2], were randomized to group A receiving meconium (n=12), or group B receiving meconium + albumin (n=12), 3 ml/kg intratracheally. The animals were reoxygenated for 8 h. Reoxygenation was started when mean arterial blood pressure was <20 mm Hg or base excess was <-20 mmol/L. During 8 h of reoxygenation the interleukin-8 concentrations in tracheobronchial aspirates increased 5-fold more in the meconium vs. the meconium + albumin groups (93+-56 vs. 18+-4 pg/mL, p<0.005). There were no differences between the groups for tumor necrosis factor α in tracheobronchial aspirates, recruitment of inflammatory cells in the airspaces or surfactant function in bronchoalveolar lavage fluid. In conclusion, albumin significantly decreased interleukin-8 concentrations in tracheobronchial aspirates after meconium aspiration.

About the article

Published Online: 2005-06-01

Published in Print: 2004-02-06


Citation Information: Journal of Perinatal Medicine, Volume 32, Issue 1, Pages 78–83, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2004.015.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Bodil Salvesen, Tom Eirik Mollnes, and Ola Didrik Saugstad
The Journal of Maternal-Fetal & Neonatal Medicine, 2008, Volume 21, Number 10, Page 719
[2]
Paal H H Lindenskov, Albert Castellheim, Geir Aamodt, Ola D Saugstad, and Tom E Mollnes
Pediatric Research, 2004, Volume 56, Number 5, Page 810
[3]
T E Mollnes, A Castellheim, P H H Lindenskov, B Salvesen, and O D Saugstad
Journal of Perinatology, 2008, Volume 28, Page S116
[4]
Paal H H Lindenskov, Albert Castellheim, Geir Aamodt, and Ola D Saugstad
Pediatric Research, 2005, Volume 57, Number 3, Page 371
[5]
A. Castellheim, P. H. H. Lindenskov, A. Pharo, G. Aamodt, O. D. Saugstad, and T. E. Mollnes
Scandinavian Journal of Immunology, 2005, Volume 61, Number 3, Page 217

Comments (0)

Please log in or register to comment.
Log in