Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


IMPACT FACTOR 2018: 1.361
5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

SCImago Journal Rank (SJR) 2018: 0.522
Source Normalized Impact per Paper (SNIP) 2018: 0.602

Online
ISSN
1619-3997
See all formats and pricing
More options …
Volume 32, Issue 4

Issues

Different maternal serum hCG levels in pregnant women with female and male fetuses: does fetal hypophyseal – adrenal – gonadal axis play a role?

M. Gol / S. Altunyurt / D. Cimrin / S. Guclu / M. Bagci / N. Demir
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/JPM.2004.064

Abstract

Fetal gender has a significant effect on maternal and cord blood hCG levels, particularly during the last trimester of the pregnancy. However, the reason for this difference is obscure. The aim of the present study was to investigate whether term fetal hypophyseal - adrenal - gonadal axis differs between female and male fetuses thereby causing different hCG levels. The study consisted of 60 women with singleton pregnancies in the third trimester. Thirtyone pregnant women were carrying female fetuses, whereas 29 were carrying male. Human chorionic gonadotropin (hCG), estradiol, progesterone, testosterone, dehydro-epiandrosteron-sulfate (DHEAS), prolactin and growth hormone levels were measured in maternal serum and umbilical cord blood.

In female bearing pregnancies maternal and cord blood hCG levels were significantly higher than in male bearing pregnancies (P<0.001). Maternal and cord blood estradiol, progesterone, testosterone, DHEAS, prolactin and growth hormone levels were not significantly different in either fetal gender. When all patients were considered as a group there were no correlations between fetal hCG levels and any of the measured hormones.

Term fetal DHEAS, estrogen, progesterone, testosterone, growth hormone and prolactin levels do not contribute to different hCG levels between female and male fetuses. It is possible that fetal hypophyseal-adrenal - gonadal axis does not play a central role as the cause of different hCG levels.

About the article

Published Online: 2005-06-01

Published in Print: 2004-07-09


Citation Information: Journal of Perinatal Medicine, Volume 32, Issue 4, Pages 342–345, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2004.064.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Feng Xiong, Qing Sun, Guan-Gui Li, Pei-Lin Chen, Zhi-Hong Yao, Cai-Yun Wan, Hui-Xian Zhong, and Yong Zeng
Taiwanese Journal of Obstetrics and Gynecology, 2019, Volume 58, Number 6, Page 833
[2]
M. Barjaktarovic, T. I. M. Korevaar, V. W. V. Jaddoe, Y. B. Rijke, R. P. Peeters, and E. A. P. Steegers
Ultrasound in Obstetrics & Gynecology, 2019, Volume 54, Number 4, Page 477
[3]
Kirk P. Conrad, Georgia M. Graham, Yueh-Yun Chi, Xiaoman Zhai, Minjie Li, R. Stan Williams, Alice Rhoton-Vlasak, Mark S. Segal, Charles E. Wood, and Maureen Keller-Wood
American Journal of Physiology-Endocrinology and Metabolism, 2019, Volume 317, Number 4, Page E677
[5]
Laura Detti, Mary E. Christiansen, Ludwig Francillon, Gini Ikuwezunma, Michael P. Diamond, Giancarlo Mari, and Ana M. Tobiasz
Systems Biology in Reproductive Medicine, 2018, Page 1
[6]
Tammy Z. Movsas, Rebecca L. Weiner, M. Banks Greenberg, David M. Holtzman, and Rafael Galindo
Frontiers in Pediatrics, 2017, Volume 5
[7]
Laura M. Glynn, Elysia Poggi Davis, Curt A. Sandman, and Wendy A. Goldberg
Hormones and Behavior, 2016, Volume 85, Page 19
[8]
Karen J. Steinman, Todd R. Robeck, and Justine K. O’Brien
General and Comparative Endocrinology, 2016, Volume 226, Page 102
[9]
L.A. Favorito, H.M. Pazos, S.F. Costa, W.S. Costa, and F.J. Sampaio
Journal of Pediatric Urology, 2014, Volume 10, Number 6, Page 1014
[10]
Josef Oswald, Isabel Heidegger, Eberhard Steiner, Erich Brenner, Michael Ladurner Rennau, Renate Pichler, Tanja Becker, Wolfgang Loidl, Wolfgang Horninger, and Helga Fritsch
Urology, 2013, Volume 82, Number 6, Page 1410
[11]
E.A.M. Kuijper, J.C.F. Ket, M.R. Caanen, and C.B. Lambalk
Reproductive BioMedicine Online, 2013, Volume 27, Number 1, Page 33
[12]
E. Macke, S. Magalhaes, F. Bach, and I. Olivieri
Proceedings of the Royal Society B: Biological Sciences, 2012, Volume 279, Number 1747, Page 4634
[14]
Cheryl S. Rosenfeld
Reproduction, Fertility and Development, 2012, Volume 24, Number 1, Page 45
[15]
Mert Gol, Ali Riza Sisman, Serkan Guclu, Sabahattin Altunyurt, Banu Onvural, and Namik Demir
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2006, Volume 128, Number 1-2, Page 253
[16]
S. J. Jordan, A. C. Green, C. M. Nagle, C. M. Olsen, D. C. Whiteman, and P. M. Webb
American Journal of Epidemiology, 2009, Volume 170, Number 5, Page 607
[17]
Mert Gol, Serkan Guclu, Ahmet Demir, Yakup Erata, and Namik Demir
Archives of Gynecology and Obstetrics, 2005, Volume 273, Number 2, Page 90
[18]
Andreas Lunacek, Josef Oswald, Christian Schwentner, Barbara Schlenck, Wolfgang Horninger, Helga Fritsch, Stefano Longato, Consolato Sergi, Georg Bartsch, and Christian Radmayr
BJU International, 2007, Volume 99, Number 1, Page 151
[19]
Prenatal Diagnosis, 2004, Volume 24, Number 12, Page 1025

Comments (0)

Please log in or register to comment.
Log in