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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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Volume 32, Issue 5 (Sep 2004)


Mother-to-infant vertical transmission of transfusion transmitted virus in South China

Xiao Xin
  • Perinatal Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou, P.R. China
/ Zhou Xiaoguang
  • Department of Neonatology, Second Affiliated Hospital of Guangzhou Medical College, Guangzhou, P.R. China
/ Zhu Ninghu
  • Maternal and Children’s Health Hospital of Guangdong Province, Guangzhou, P.R. China
/ Luo Youtong
  • Perinatal Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou, P.R. China
/ Xu Liumei
  • Shenzhen Research Institute of Hepatology, Shenzhen, P.R. China
/ Zhou Boping
  • Shenzhen Research Institute of Hepatology, Shenzhen, P.R. China
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/JPM.2004.136


A nested PCR was used to detect TTV DNA in serum from 490 mother-infant pairs to determine the rate of vertical transmission of TTV in Guangzhou City, P.R. China. TTV DNA was positive in 87 mothers and 12 of their babies, giving a prevalence of 17.8% in pregnant women and a mother-to-child transmission rate of 13.8%. In eight mother-infant pairs, TTV DNA nucleotide sequences from the mothers and their corresponding infants were identical. The homology of Guangzhou TTV and Japanese TTV ranged from 85.3%–98.2% at nucleotide level. TTV infection is common in pregnant women in South China and vertical transmission can occur. Guangzhou’s and Japanese TTV isolates belong to the same genotype.

Keywords: Genetics; infant; nested polymerase chain reaction; pregnancy; transfusion transmitted virus; vertical transmission


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About the article

Corresponding author: Dr. Xin Xiao Perinatal Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou 510632/P.R. China. Fax: +86-20-38688000, E-mail:

Received: October 22, 2003

Revised: April 28, 2004

Accepted: May 9, 2004

Published Online: 2005-06-01

Published in Print: 2004-09-01

Citation Information: Journal of Perinatal Medicine, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2004.136. Export Citation

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