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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year


IMPACT FACTOR 2016: 1.577
5-year IMPACT FACTOR: 1.705

CiteScore 2016: 1.49

SCImago Journal Rank (SJR) 2016: 0.602
Source Normalized Impact per Paper (SNIP) 2016: 0.832

Online
ISSN
1619-3997
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Volume 33, Issue 3 (May 2005)

Issues

Pregnancy outcome of euploid fetuses with increased nuchal translucency: how bad is the news?

Ron Maymon
  • Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
/ Zwi Weinraub
  • Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
/ Arie Herman
  • Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Published Online: 2005-07-05 | DOI: https://doi.org/10.1515/JPM.2005.036

Abstract

Aims: The number of fetuses with an abnormal increased first trimester nuchal translucency (NT), but confirmed normal karyotype and anatomy is relatively small and therefore a challenge for prenatal counseling. Universal guidelines are still needed for a systematic work-up, how to decide on the rewarding cut-off for this policy as well as how to counsel patients with an increased NT but with euploid fetuses. The current review aims to address some of these issues.

Results: Eleven studies reporting on the pregnancy outcome of 2,128 euploid fetuses with increased NT (≥3 mm or ≥95 centile) were retrieved by our previously reported literature search. 2.2–10.6% of the fetuses has miscarried and 0.5–15.8% ended in perinatal death. There was an overall rate of 0.5–13% neurodevelopmental problems, and 2–8% of the malformations were undiagnosed before birth, the most common being cardiac anomalies. Nevertheless, 70–90% fetuses had normal outcomes.

Conclusion: For those euploid fetuses with increased NT >2 MoM or ≥1.5 mm delta NT we recommend a detailed two-step anomaly scan including midgestation fetal echocardiography. Maternal age as well as data on relevant family history and persistence of nuchal edema provides additional relevant information for counseling and planning pregnancy management.

Keywords: Euploid fetuses; fetal abnormalities; increased nuchal translucency; pregnancy outcome.

About the article

Corresponding author: Ron Maymon, MD, Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin 70300, Israel. Tel.: 972-3-6407445 Fax: 972-3-6409043 E-mail:


Published Online: 2005-07-05

Published in Print: 2005-05-01


Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2005.036.

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