Jump to ContentJump to Main Navigation
Show Summary Details

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year


IMPACT FACTOR increased in 2015: 1.798
Rank 46 out of 120 in category Pediatrics in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.731
Source Normalized Impact per Paper (SNIP) 2014: 0.687
Impact per Publication (IPP) 2014: 1.483

Online
ISSN
1619-3997
See all formats and pricing
Volume 33, Issue 5 (Oct 2005)

Issues

The best marker combination using the integrated screening test approach for detecting various chromosomal aneuploidies

Ron Maymon
  • Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Israel
/ Reuven Sharony
  • The Genetic Institute, Sapir Medical Center, Meir Hospital, Kfar Saba, Israel
/ Julia Grinshpun-Cohen
  • The Genetic Institute, Sapir Medical Center, Meir Hospital, Kfar Saba, Israel
/ Deganit Itzhaky
  • The Immunology Laboratory, Sapir Medical Center, Meir Hospital, Kfar Saba, Israel
/ Arie Herman
  • Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Israel
/ Orit Reish
  • The Genetics Institute, Assaf Harofe Medical Center, Israel, both medical centers affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Published Online: 2005-09-13 | DOI: https://doi.org/10.1515/JPM.2005.071

Abstract

Aims: To evaluate the cross-trimester multiple marker correlation and the minimum marker combination needed for detecting various chromosomal aneuploidies.

Materials and methods: Parturient women with singleton pregnancies who underwent non-interventional sequential screening test and followed prospectively were recruited. They all underwent first trimester combined nuchal translucency (NT), pregnancy-associated plasma protein-A (PAPP-A), and free β-human chorionic gonadotrophin (f-βhCG), followed by second trimester measurement of unconjugated estriol (uE3), human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP). Pearson correlation was applied to compute any cross-trimester marker correlation and logistic regression analysis was used to determine the minimum marker combination for detecting various categories of chromosomal aneuploidies.

Results: The current study included 552 normal and 43 chromosomal-affected pregnancies (24 Down's syndrome [DS], 7 Turner's syndrome, 8 Edward's syndrome, 4 Klinefelter syndrome and 5 triploidy) for which the results of both the screening tests and the pregnancy outcome were available. In the normal cases, a significant correlation was found between f-βhCG and hCG (r=0.52), as well as between PAPP-A and uE3 (r=0.174). In DS pregnancies, the NT correlated with both hCG (r=0.45) and uE3 (r=−0.39). In Turner's syndrome, uE3 correlated both with PAPP-A (r=0.97) and f-βhCG (r=0.97). No other significant correlations were found. Furthermore, with the exception of f-βhCG and hCG in the unaffected cases, all other markers correlation appeared very weak. For detecting all the above categories of aneuploidies, the combination of NT, PAPP-A and uE3 and the maternal age background risk were found adequate, with a 74% detection rate (DR) for a 5% false positive rate (FPR). For DS only, the combination of maternal age-related background risk and the combination of NT, PAPP-A, hCG and AFP yielded a 79% DR for a 5% FPR.

Conclusions: The current study agrees with a previous report that, overall, there is no strong correlation between first and second trimester markers. The extension of the integrated test for detecting various categories of common chromosomal aneuploidies using NT, PAPP-A and uE3 deserves further evaluation.

Keywords: Chromosomal abnormalities; Down's syndrome screening; integrated test; marker combination

References

  • 1

  • 2

  • 3

  • 4

  • 5

  • 6

  • 7

  • 8

  • 9

  • 10

  • 11

  • 12

  • 13

  • 14

  • 15

  • 16

  • 17

  • 18

  • 19

  • 20

  • 21

  • 22

  • 23

  • 24

  • 25

  • 26

  • 27

  • 28

  • 29

  • 30

  • 31

  • 32

  • 33

About the article

Corresponding author: Ron Maymon, MD Department of Obstetrics and Gynecology Assaf Harofe Medical Center Zerifin Israel Tel.: +972-3-6407445 Fax: +972-3-6409043


Received: February 11, 2005

Revised: May 17, 2005

Accepted: May 24, 2005

Published Online: 2005-09-13

Published in Print: 2005-10-01


Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2005.071. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Zvi Vaknin, Orit Reish, Ido Ben-Ami, Eli Heyman, Arie Herman, and Ron Maymon
Fetal Diagnosis and Therapy, 2008, Volume 23, Number 1, Page 76

Comments (0)

Please log in or register to comment.
Log in