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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica

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CiteScore 2018: 1.29

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Volume 33, Issue 5


Special relationships between fetal inflammatory response syndrome and bronchopulmonary dysplasia in neonates

Robert Mittendorf / Robert Covert / Anthony G. Montag / Wafic elMasri / Jonathan Muraskas
  • Division of Neonatology, Department of Pediatrics, Loyola University Medical Center, Maywood, IL, USA
  • Other articles by this author:
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/ Kwang-Sun Lee / Peter G. Pryde
Published Online: 2005-09-13 | DOI: https://doi.org/10.1515/JPM.2005.076


Objective: To confirm previous known relationships between Fetal Inflammatory Response Syndrome (FIRS) and neonatal bronchopulmonary dysplasia (BPD) and to present information on previously unknown special relationships between inflammatory variables and BPD.

Study design: At delivery, we obtained biological specimens including umbilical cord venous blood for plasma interleukin-6 levels, as well as placental histology and bacteriology. Among other neonatal outcomes, we collected prospective information on BPD.

Results: Of 141 newborns in the study, 16 had BPD; 79% of these had antecedent FIRS, 27% of those without FIRS had BPD. By multivariable regression, only very low birth weight (adjusted [adj] odds ratio [OR] 32.0, 95% Confidence Interval [CI] 5.0 to positive infinity) and FIRS (adj OR 5.7, 95% CI 1.1 to 42.3) remained significant risk factors. Escherichia coli, perhaps due to its pyogenic nature (strongly elicits inflammatory responses), may have had a special relationship with BPD.

Conclusions: In our data, FIRS and neonatal BPD are highly associated. It is possible that certain pyogenic bacteria in the chorioamnion space may be implicated more often than others.

Condensation: Neonates having Fetal Inflammatory Response Syndrome at delivery may later develop BPD. Pyogenic bacteria, such as Escherichia coli, may be implicated more frequently.

Keywords: BPD; FIRS

About the article

Corresponding author: Dr. Robert Mittendorf Department of Obstetrics and Gynecology Loyola University Medical Center 2160 First Avenue, Maywood, IL 60153/USA Tel.: +708-216-2465 Fax: +708-216-5669

Received: December 9, 2004

Revised: April 13, 2005

Accepted: April 15, 2005

Published Online: 2005-09-13

Published in Print: 2005-10-01

Citation Information: Journal of Perinatal Medicine, Volume 33, Issue 5, Pages 428–434, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2005.076.

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