Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


IMPACT FACTOR 2018: 1.361
5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

SCImago Journal Rank (SJR) 2018: 0.522
Source Normalized Impact per Paper (SNIP) 2018: 0.602

Online
ISSN
1619-3997
See all formats and pricing
More options …
Volume 33, Issue 6

Issues

Perinatal outcomes and the use of oral hypoglycemic agents

Anna Maria Bertini / Jean Carl Silva / Wladimir Taborda / Felipe Becker / Fernanda Regina Lemos Bebber / Juliana Maria Zucco Viesi / Gabriela Aquim / Thaís Engel Ribeiro
Published Online: 2005-12-01 | DOI: https://doi.org/10.1515/JPM.2005.092

Abstract

Objective: To compare neonatal results from patients with gestational diabetes mellitus (GDM) who were treated with insulin, glyburide and acarbose.

Results: Seventy patients diagnosed with GDM who needed therapy to complement diet and physical activities were included in the study. One group was assigned to insulin therapy (n=27), a second group was assigned to glyburide therapy (n=24) and a third group was assigned to acarbose therapy (n=19). Maternal characteristics were similar in the three groups. Glucose control was not achieved in five (20.8%) of the patients using glyburide and in eight (42.1%) of patients using acarbose. No statistical difference was observed in fasting and post-prandial glucose levels or in average newborn weight in the three groups. The rate of large for gestational age (LGA) fetuses was 3.7, 25 and 10.5% in the groups treated with insulin, glyburide and acarbose, respectively. Neonatal hypoglycemia was observed in eight newborns, six of which from the glyburide group.

Conclusion: We believe that glyburide and acarbose can be promising alternative therapies for the treatment of GDM. Glyburide controlled glucose levels in most patients and it was more efficient than acarbose. Glyburide showed a higher rate of macrosomia and neonatal hypoglycemia as compared to other therapies.

Keywords: Acarbose; gestational diabetes mellitus; glyburide; oral hypoglycemic agents

About the article

Corresponding author: Jean Carl Silva TEGO 0143/1992 Rua Oscar Schneider 205, casa 10 Joinville – SC CEP 89203-050 Brazil Tel.: 55 47 4221356 Fax: 55 47 4226912


Received: February 15, 2005

Revised: June 21, 2005

Accepted: July 22, 2005

Published Online: 2005-12-01

Published in Print: 2005-12-01


Citation Information: Journal of Perinatal Medicine, Volume 33, Issue 6, Pages 519–523, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2005.092.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Rachel A. Blair, Emily A. Rosenberg, and Nadine E. Palermo
Current Diabetes Reports, 2019, Volume 19, Number 12
[2]
Lanlan Guo, Jing Ma, Jia Tang, Dingyao Hu, Wei Zhang, and Xue Zhao
Journal of Diabetes Research, 2019, Volume 2019, Page 1
[3]
Elizabeth Buschur, Florence Brown, and Jennifer Wyckoff
Current Diabetes Reports, 2015, Volume 15, Number 2
[4]
Jean Carl Silva, Bárbara Vicente de Souza, and Mariana Ribeiro e Silva
Revista Brasileira de Saúde Materno Infantil, 2013, Volume 13, Number 2, Page 129
[5]
Maisa N. Feghali, Jason G. Umans, and Patrick M. Catalano
Clinics in Perinatology, 2019, Volume 46, Number 2, Page 257
[6]
Diane Farrar, Mark Simmonds, Maria Bryant, Trevor A Sheldon, Derek Tuffnell, Su Golder, and Debbie A Lawlor
BMJ Open, 2017, Volume 7, Number 6, Page e015557
[7]
Matthew M. Finneran and Mark B. Landon
Current Diabetes Reports, 2018, Volume 18, Number 11
[8]
Ruth Martis, Caroline A Crowther, Emily Shepherd, Jane Alsweiler, Michelle R Downie, and Julie Brown
Cochrane Database of Systematic Reviews, 2018
[9]
Deborah J. Wexler, Camille E. Powe, Linda A. Barbour, Thomas Buchanan, Donald R. Coustan, Rosa Corcoy, Peter Damm, Fidelma Dunne, Denice S. Feig, Assiamira Ferrara, Lorie M. Harper, Mark B. Landon, Sara J. Meltzer, Boyd E. Metzger, Hilary Roeder, Janet A. Rowan, David A. Sacks, David Simmons, Jason G. Umans, and Patrick M. Catalano
Obstetrics & Gynecology, 2018, Volume 132, Number 2, Page 496
[10]
L. Bougherara, S. Hanssens, D. Subtil, A. Vambergue, and P. Deruelle
EMC - Ginecología-Obstetricia, 2018, Volume 54, Number 1, Page 1
[11]
Rosa Corcoy, Montserrat Balsells, Apolonia García-Patterson, Anat Shmueli, and Eran Hadar
Diabetes Research and Clinical Practice, 2018
[12]
Denice S. Feig, Howard Berger, Lois Donovan, Ariane Godbout, Tina Kader, Erin Keely, and Rema Sanghera
Canadian Journal of Diabetes, 2018, Volume 42, Page S255
[13]
Claudia Caissutti, Gabriele Saccone, Adeeb Khalifeh, A. Dhanya Mackeen, Melisa Lott, and Vincenzo Berghella
The Journal of Maternal-Fetal & Neonatal Medicine, 2018, Page 1
[14]
[15]
Claudia Caissutti, Gabriele Saccone, Andrea Ciardulli, and Vincenzo Berghella
Acta Obstetricia et Gynecologica Scandinavica, 2017
[16]
M.-V. Senat
Médecine des Maladies Métaboliques, 2017, Volume 11, Number 6, Page 510
[18]
Juliana B. do Valle, Jean C. Silva, Daniela S. Oliveira, Lisiane Martins, Amanda Lewandowski, and Wagner Horst
International Journal of Gynecology & Obstetrics, 2017
[20]
Rongjing Song, Ling Chen, Yue Chen, Xia Si, Yi Liu, Yue Liu, David M. Irwin, Wanyu Feng, and Zhong-Cheng Luo
PLOS ONE, 2017, Volume 12, Number 8, Page e0182488
[21]
Letícia Schwerz Weinert, Sandra Pinho Silveiro, Maria Lúcia Oppermann, Cristiano Caetano Salazar, Bárbara Marina Simionato, Aline Siebeneichler, and Angela Jacob Reichelt
Arquivos Brasileiros de Endocrinologia & Metabologia, 2011, Volume 55, Number 7, Page 435
[22]
Denice S Feig, Gerald G Briggs, and Gideon Koren
Annals of Pharmacotherapy, 2007, Volume 41, Number 7-8, Page 1174
[23]
Nalinee Poolsup, Naeti Suksomboon, Muhammad Amin, and Marta L. Hribal
PLoS ONE, 2014, Volume 9, Number 10, Page e109985
[24]
Diane Farrar, Mark Simmonds, Susan Griffin, Ana Duarte, Debbie A Lawlor, Mark Sculpher, Lesley Fairley, Su Golder, Derek Tuffnell, Martin Bland, Fidelma Dunne, Donald Whitelaw, John Wright, and Trevor A Sheldon
Health Technology Assessment, 2016, Volume 20, Number 86, Page 1
[25]
K. M. Bircsak, V. Gupta, P. Y. S. Yuen, L. Gorczyca, B. I. Weinberger, A. M. Vetrano, and L. M. Aleksunes
Journal of Pharmacology and Experimental Therapeutics, 2016, Volume 357, Number 1, Page 103
[26]
M.-V. Senat and P. Deruelle
Gynécologie Obstétrique & Fertilité, 2016, Volume 44, Number 4, Page 244
[27]
Len Kelly
Journal of Obstetrics and Gynaecology Canada, 2008, Volume 30, Number 2, Page 116
[28]
Barak M. Rosenn
The Journal of Maternal-Fetal & Neonatal Medicine, 2010, Volume 23, Number 3, Page 219
[29]
L M Harper, A V Glover, J R Biggio, and A Tita
Journal of Perinatology, 2016, Volume 36, Number 5, Page 347
[30]
Oded Langer
Maternal Health, Neonatology and Perinatology, 2015, Volume 1, Number 1
[31]
David Salat and Cristina Aguilera
Medicina Clínica, 2015, Volume 145, Number 6, Page 269
[32]
Jephthah O. Odiba and Mzwandile A. Mabhala
Journal of Diabetes Mellitus, 2015, Volume 05, Number 02, Page 58
[33]
Wendy Camelo Castillo, Kim Boggess, Til Stürmer, M. Alan Brookhart, Daniel K. Benjamin, and Michele Jonsson Funk
Obstetrics & Gynecology, 2014, Volume 123, Number 6, Page 1177
[34]
Canadian Journal of Diabetes, 2013, Volume 37, Page S654
[35]
Awadhesh Kumar Singh and Ritu Singh
Expert Review of Endocrinology & Metabolism, 2015, Volume 10, Number 2, Page 211
[36]
Diana L. Shuster, Linda J. Risler, Bhagwat Prasad, Justina C. Calamia, Jenna L. Voellinger, Edward J. Kelly, Jashvant D. Unadkat, Mary F. Hebert, Danny D. Shen, Kenneth E. Thummel, and Qingcheng Mao
Biochemical Pharmacology, 2014, Volume 92, Number 4, Page 690
[37]
Rachel J. Ryu, Karen E. Hays, and Mary F. Hebert
Seminars in Perinatology, 2014, Volume 38, Number 8, Page 508
[38]
Ya-chang Zeng, Mu-jun Li, Yue Chen, Li Jiang, Su-mei Wang, Xiao-liang Mo, and Bin-yi Li
Advances in Medical Sciences, 2014, Volume 59, Number 1, Page 95
[39]
Wanda Nicholson, Shari Bolen, Catherine Takacs Witkop, Donna Neale, Lisa Wilson, and Eric Bass
Obstetrics & Gynecology, 2009, Volume 113, Number 1, Page 193
[40]
R. I. G. Holt and K. D. Lambert
Diabetic Medicine, 2014, Volume 31, Number 3, Page 282
[41]
David Thompson, Howard Berger, Denice Feig, Robert Gagnon, Tina Kader, Erin Keely, Sharon Kozak, Edmond Ryan, Mathew Sermer, and Christina Vinokuroff
Canadian Journal of Diabetes, 2013, Volume 37, Page S548
[43]
Canadian Journal of Diabetes, 2013, Volume 37, Page S343
[44]
Niranjan Thomas, Annie Jothirmayi Chinta, Santhanam Sridhar, Manish Kumar, Kurien Anil Kuruvilla, and Atanu Kumar Jana
Indian Pediatrics, 2013, Volume 50, Number 3, Page 289
[45]
Nagandla Kavitha, Somsubhra De, and Sachchithanantham Kanagasabai
The Journal of Obstetrics and Gynecology of India, 2013, Volume 63, Number 2, Page 82
[46]
David Thompson, Howard Berger, Denice Feig, Robert Gagnon, Tina Kader, Erin Keely, Sharon Kozak, Edmond Ryan, Mathew Sermer, and Christina Vinokuroff
Canadian Journal of Diabetes, 2013, Volume 37, Page S168
[47]
F. Kainer
Der Diabetologe, 2012, Volume 8, Number 8, Page 639
[48]
Yvonne W. Cheng, Judith H. Chung, Ingrid Block-Kurbisch, Maribeth Inturrisi, and Aaron B. Caughey
The Journal of Maternal-Fetal & Neonatal Medicine, 2012, Volume 25, Number 4, Page 379
[49]
G. Carles, L. Germain, N. Alassas, W. El Guindi, F. Dallah, and J.-L. Daigre
Journal de Gynécologie Obstétrique et Biologie de la Reproduction, 2010, Volume 39, Number 2, Page 139
[50]
S. Jacqueminet and M.-F. Jannot-Lamotte
Journal de Gynécologie Obstétrique et Biologie de la Reproduction, 2010, Volume 39, Number 8, Page S251
[51]
Jerrie S. Refuerzo
Obstetrics and Gynecology Clinics of North America, 2011, Volume 38, Number 2, Page 227
[52]
Oded Langer
Obstetrics and Gynecology Clinics of North America, 2007, Volume 34, Number 2, Page 255
[53]
Wanda Nicholson and Kesha Baptiste-Roberts
Best Practice & Research Clinical Obstetrics & Gynaecology, 2011, Volume 25, Number 1, Page 51
[54]
Jürgen Harreiter and Alexandra Kautzky-Willer
Wiener klinische Wochenschrift Education, 2011, Volume 6, Number 3, Page 51
[55]
Jaya Saxena Dhulkotia, Bolarinde Ola, Robert Fraser, and Tom Farrell
American Journal of Obstetrics and Gynecology, 2010, Volume 203, Number 5, Page 457.e1
[56]
Jean Carl Silva, Carina Pacheco, Juliana Bizato, Bárbara Vicente de Souza, Thaís Engel Ribeiro, and Anna Maria Bertini
International Journal of Gynecology & Obstetrics, 2010, Volume 111, Number 1, Page 37
[57]
Ana Cristina Maymone, Jean-Patrice Baillargeon, Julie Ménard, and Jean-Luc Ardilouze
Expert Opinion on Drug Safety, 2011, Volume 10, Number 2, Page 227
[58]
Nir Melamed and Yariv Yogev
Women's Health, 2009, Volume 5, Number 6, Page 649
[59]
Y W Cheng and A B Caughey
Journal of Perinatology, 2008, Volume 28, Number 10, Page 657
[60]
R. I. G. Holt, P. Clarke, E. C. Parry, and M. A. G. Coleman
Diabetes, Obesity and Metabolism, 2008, Volume 10, Number 10, Page 906

Comments (0)

Please log in or register to comment.
Log in