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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica

IMPACT FACTOR 2018: 1.361
5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

SCImago Journal Rank (SJR) 2018: 0.522
Source Normalized Impact per Paper (SNIP) 2018: 0.602

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Volume 33, Issue 6


Perinatal outcomes and the use of oral hypoglycemic agents

Anna Maria Bertini / Jean Carl Silva / Wladimir Taborda / Felipe Becker / Fernanda Regina Lemos Bebber / Juliana Maria Zucco Viesi / Gabriela Aquim / Thaís Engel Ribeiro
Published Online: 2005-12-01 | DOI: https://doi.org/10.1515/JPM.2005.092


Objective: To compare neonatal results from patients with gestational diabetes mellitus (GDM) who were treated with insulin, glyburide and acarbose.

Results: Seventy patients diagnosed with GDM who needed therapy to complement diet and physical activities were included in the study. One group was assigned to insulin therapy (n=27), a second group was assigned to glyburide therapy (n=24) and a third group was assigned to acarbose therapy (n=19). Maternal characteristics were similar in the three groups. Glucose control was not achieved in five (20.8%) of the patients using glyburide and in eight (42.1%) of patients using acarbose. No statistical difference was observed in fasting and post-prandial glucose levels or in average newborn weight in the three groups. The rate of large for gestational age (LGA) fetuses was 3.7, 25 and 10.5% in the groups treated with insulin, glyburide and acarbose, respectively. Neonatal hypoglycemia was observed in eight newborns, six of which from the glyburide group.

Conclusion: We believe that glyburide and acarbose can be promising alternative therapies for the treatment of GDM. Glyburide controlled glucose levels in most patients and it was more efficient than acarbose. Glyburide showed a higher rate of macrosomia and neonatal hypoglycemia as compared to other therapies.

Keywords: Acarbose; gestational diabetes mellitus; glyburide; oral hypoglycemic agents

About the article

Corresponding author: Jean Carl Silva TEGO 0143/1992 Rua Oscar Schneider 205, casa 10 Joinville – SC CEP 89203-050 Brazil Tel.: 55 47 4221356 Fax: 55 47 4226912

Received: February 15, 2005

Revised: June 21, 2005

Accepted: July 22, 2005

Published Online: 2005-12-01

Published in Print: 2005-12-01

Citation Information: Journal of Perinatal Medicine, Volume 33, Issue 6, Pages 519–523, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2005.092.

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