Jump to ContentJump to Main Navigation
Show Summary Details

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

IMPACT FACTOR increased in 2015: 1.798
Rank 46 out of 120 in category Pediatrics in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.731
Source Normalized Impact per Paper (SNIP) 2014: 0.687
Impact per Publication (IPP) 2014: 1.483

99,00 € / $149.00 / £75.00*

See all formats and pricing


Select Volume and Issue


Perinatal outcomes of spontaneous twins compared with twins conceived through intracytoplasmic sperm injection

Burcu Saygan-Karamürsel1 / Özlem Tekşam2 / Tarık Aksu3 / Murat Yurdakök4 / Lütfü Önderoğlu5






Corresponding author: Burcu Saygan-Karamürsel, Kenedi Cad, 111/23 GOP, Ankara, Turkey Tel.: +90-532-4336003

Citation Information: Journal of Perinatal Medicine. Volume 34, Issue 2, Pages 132–138, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/JPM.2006.024, March 2006

Publication History

March 24, 2005
September 21, 2005
October 2, 2005
Published Online:


Objective: To compare perinatal outcomes in spontaneous twins compared with those conceived by intracytoplasmic sperm injection (ICSI).

Design: Retrospective case-control study.

Patients: Cases consisted of 274 intracytoplasmic sperm injection twins, controls were 348 naturally conceived twins delivered between 1999 and 2003 in a tertiary hospital.

Main outcome measures: Birth weight, gestational age at birth, cesarean delivery rate, perinatal mortality and morbidity, congenital anomalies, gestational diabetes and pregnancy induced hypertension.

Results: Preterm deliveries (76.6% vs. 64.1% <37 weeks and 19.7% vs. 13.2% <32 weeks) and low birth weight (73% vs. 60.3% <2500 g and 19.7% vs. 12.6% <1500 g) were significantly higher in the ICSI group compared with controls. Gestational diabetes mellitus (8% vs. 2.9%) and cesarean deliveries (95.2% vs. 77.6%) were more common in cases compared with the control group. There was a significantly higher rate of perinatal morbidity (16.4% vs. 7.8%) and mortality (8% vs. 2.6%) in ICSI twins. The incidence of congenital malformations diagnosed at birth was higher in cases (4.4%) compared with controls (0.9%) but the difference was not significant when adjusted for maternal age.

Conclusion: Perinatal outcomes of twins after ICSI treatment are less optimal than naturally conceived twins.

Keywords: Congenital anomalies; ICSI; perinatal morbidity; perinatal mortality; perinatal outcome; twinning

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

N. N. Sarkar
Journal of Obstetrics and Gynaecology, 2007, Volume 27, Number 4, Page 347
Jiabi Qin, Xiaoqi Sheng, Hua Wang, Desheng Liang, Hongzhuan Tan, and Jiahui Xia
Archives of Gynecology and Obstetrics, 2015
M. Hansen, J. J. Kurinczuk, E. Milne, N. de Klerk, and C. Bower
Human Reproduction Update, 2013, Volume 19, Number 4, Page 330
A. Moini, M. Shiva, A. Arabipoor, R. Hosseini, M. Chehrazi, and M. Sadeghi
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2012, Volume 165, Number 1, Page 29
C Thomopoulos, C Tsioufis, H Michalopoulou, T Makris, V Papademetriou, and C Stefanadis
Journal of Human Hypertension, 2013, Volume 27, Number 3, Page 148
Juan Wen, Jie Jiang, Chenyue Ding, Juncheng Dai, Yao Liu, Yankai Xia, Jiayin Liu, and Zhibin Hu
Fertility and Sterility, 2012, Volume 97, Number 6, Page 1331
G. Sebastiani, A. Pertierra Cortada, E. Vidal Sordé, J. Figueras Aloy, and J. Balasch Cortina
Anales de Pediatría, 2009, Volume 70, Number 4, Page 323
Shi Wu Wen, Arthur Leader, Ruth Rennicks White, Marie-Claude Léveillé, Valerie Wilkie, Jia Zhou, and Mark C. Walker
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2010, Volume 150, Number 2, Page 160

Comments (0)

Please log in or register to comment.