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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica

IMPACT FACTOR 2018: 1.361
5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

SCImago Journal Rank (SJR) 2018: 0.522
Source Normalized Impact per Paper (SNIP) 2018: 0.602

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Volume 34, Issue 3


The chemical erosion of human health: adverse environmental exposure and in-utero pollution – determinants of congenital disorders and chronic disease

Stephen J. Genuis
  • Department of Obstetrics and Gynecology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
  • Other articles by this author:
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Published Online: 2006-04-07 | DOI: https://doi.org/10.1515/JPM.2006.033


Epidemiological research designed to explore causality of illness has produced increasing evidence to verify that exposure to toxic agents is contributing to the escalating burden of chronic affliction, including congenital disorders. While endeavoring to facilitate optimal health and well-being for patients, the medical profession is currently challenged by the consequences of environmental factors unique to the modern era. In the last half century, there have been profound shifts in health-related habits of individuals and population groups, and recent research suggests that changes in the home and workplace environment are responsible for many common health problems including various congenital anomalies. As a result of increasing concern about environmental influences on health, ‘Human Exposure Assessment,’ the investigation and study of specific patient exposures and related health concerns, is a rapidly expanding area of scientific research. Practitioners of clinical medicine, including providers of maternity care, should acquire the skills to elicit a proper environmental exposure history and the necessary tools to implement proactive patient education relating to precautionary avoidance.

Keywords: Chronic disease; congenital anomalies; endocrine disrupting chemicals; environmental health; hormone disruption; human exposure assessment; precautionary avoidance; preconception care; prenatal care; toxicology


About the article

Corresponding author: Dr. Stephen Genuis, MD FRCSC, DABOG, 2935-66 Street Edmonton, Alberta Canada T6K 4C1 Tel.: +1 (780) 450 3504 Fax: +1 (780) 490 1803

Published Online: 2006-04-07

Published in Print: 2006-05-01

Citation Information: Journal of Perinatal Medicine, Volume 34, Issue 3, Pages 185–195, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2006.033.

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Stephen J. Genuis, Gerry Schwalfenberg, Anna-Kristen J. Siy, Ilya Rodushkin, and Daniel S. Sem
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Obstetrics and Gynecology International, 2015, Volume 2015, Page 1
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International Journal of Environmental Research and Public Health, 2011, Volume 8, Number 12, Page 2770
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European Journal of Internal Medicine, 2007, Volume 18, Number 7, Page 516
S.J. Genuis, D. Birkholz, M. Ralitsch, and N. Thibault
Public Health, 2010, Volume 124, Number 7, Page 367
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Science of The Total Environment, 2010, Volume 408, Number 24, Page 6047
Stephen J. Genuis, Detlef Birkholz, Ilia Rodushkin, and Sanjay Beesoon
Archives of Environmental Contamination and Toxicology, 2011, Volume 61, Number 2, Page 344
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Reproductive Toxicology, 2008, Volume 26, Number 2, Page 81
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Pediatrics International, 2010, Volume 52, Number 4, Page 640
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Journal of Evaluation in Clinical Practice, 2008, Volume 14, Number 1, Page 94
Maurizio Guida, Marco Guida, Bruna De Felice, Daniela Santafede, Raffaella D'Alessandro, Attilio Di Spiezio Sardo, Marianna Scognamiglio, Cinzia Ferrara, Giuseppe Bifulco, and Carmine Nappi
Journal of Biomedicine and Biotechnology, 2010, Volume 2010, Page 1
Rodney L. Rouse, Marc J. Boudreaux, and Arthur L. Penn
Environmental Health Perspectives, 2007, Volume 115, Number 12, Page 1757
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Journal of Forensic Sciences, 2009, Volume 54, Number 2, Page 474
Mrinal K. Sanyal and You-Lan Li
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007, Volume 80, Number 5, Page 367
Mrinal K. Sanyal, Derya Mercan, Kathleen Belanger, and Regina M. Santella
Birth Defects Research Part A: Clinical and Molecular Teratology, 2007, Volume 79, Number 4, Page 289

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