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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year


IMPACT FACTOR 2016: 1.577
5-year IMPACT FACTOR: 1.705

CiteScore 2016: 1.49

SCImago Journal Rank (SJR) 2016: 0.602
Source Normalized Impact per Paper (SNIP) 2016: 0.832

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1619-3997
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Volume 34, Issue 6 (Dec 2006)

Issues

Normal and abnormal transformation of the spiral arteries during pregnancy

Jimmy Espinoza
  • Perinatology Research Branch, NICHD, NIH, DHHS, Detroit MI 48201, and Bethesda MD 20892, USA and Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit MI 48201, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Roberto Romero
  • Perinatology Research Branch, NICHD, NIH, DHHS, Detroit MI 48201, and Bethesda MD 20892, USA and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit MI 48201, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Yeon Mee Kim
  • Perinatology Research Branch, NICHD, NIH, DHHS, Detroit MI 48201, and Bethesda MD 20892, USA and Department of Pathology, Wayne State University School of Medicine, Detroit MI 48201, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Juan Pedro Kusanovic / Sonia Hassan
  • Perinatology Research Branch, NICHD, NIH, DHHS, Detroit MI 48201, and Bethesda MD 20892, USA and Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit MI 48201, USA
  • Other articles by this author:
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/ Offer Erez / Francesca Gotsch / Nandor Gabor Than / Zoltan Papp / Chong Jai Kim
  • Perinatology Research Branch, NICHD, NIH, DHHS, Detroit MI 48201, and Bethesda MD 20892, USA and Department of Pathology, Wayne State University School of Medicine, Detroit MI 48201, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2006-12-01 | DOI: https://doi.org/10.1515/JPM.2006.089

Abstract

This article reviews the anatomy and physiology of the uterine circulation, with emphasis on the remodeling of spiral arteries during normal pregnancy, and the timing and anatomical pathways of trophoblast invasion of the spiral arteries. We review the definitions of the placental bed and basal plate of the placenta, their relevance to the study of the physiologic transformation of the spiral arteries, as well as the methods to obtain and examine placental bed biopsy specimens. We also examine the role of the extravillous trophoblast in normal and abnormal pregnancies, and the criteria used to diagnose failure of physiologic transformation of the spiral arteries. Finally, we comment on the use of uterine artery Doppler velocimetry as a surrogate marker of chronic uteroplacental ischemia.

Keywords: Atherosis; immunohistochemistry; impedance to blood flow; integrin; physiologic transformation of the spiral arteries; placental bed

References

About the article

Corresponding author: Roberto Romero, MD Chief, Perinatology Research Branch Intramural Division, NICHD, NIH, DHHS National Institute of Child Health and Human Development Perinatology Research Branch Hutzel Women's Hospital–4th Floor 3990 John R Detroit, MI 48201/USA Tel.: +1 (313) 993-2700 Fax: +1 (313) 993-2694


Received: July 24, 2006

Accepted: September 7, 2006

Published Online: 2006-12-01

Published in Print: 2006-12-01


Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2006.089.

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