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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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Volume 35, Issue 2 (Apr 2007)


The potential role of high or low birthweight as risk factor for adult schizophrenia

Giuseppe Bersani
  • University “La Sapienza”, III Psychiatric Clinic, University of Rome, Italy
/ Giorgiana Manuali
  • University “La Sapienza”, III Psychiatric Clinic, University of Rome, Italy
/ Luisa Ramieri
  • University “La Sapienza”, III Psychiatric Clinic, University of Rome, Italy
/ Ines Taddei
  • University “La Sapienza”, III Psychiatric Clinic, University of Rome, Italy
/ Iliana Bersani
  • University “Cattolica del Sacro Cuore”, Rome, Italy
/ Filippo Conforti
  • University “La Sapienza”, Department of Public Health, Rome, Italy
/ Maria Sofia Cattaruzza
  • University “La Sapienza”, Department of Public Health, Rome, Italy
/ John Osborn
  • University “La Sapienza”, Department of Public Health, Rome, Italy
/ Paolo Pancheri
  • University “La Sapienza”, III Psychiatric Clinic, University of Rome, Italy
Published Online: 2007-03-07 | DOI: https://doi.org/10.1515/JPM.2007.021


Objective: Obstetric complications may be an important factor in the development of schizophrenia. The aim of this study is to evaluate the role of these complications in the development of schizophrenia in adult life, with particular attention to the potential role of birth weight.

Method: We carried out a case-control study, comprising schizophrenics and patients with diseases of the schizophrenia spectrum as cases, and their healthy male brothers as controls. Obstetric complications were assessed using the “Midwife Protocol” of Parnas et al.

Results: The main result was that birth weight may be a risk factor for schizophrenia, as indicated by odds ratio analysis. The confidence intervals are very wide and, without compromising the clinical significance of the results, they give a limited indication of the real entity of the risk.

Conclusions: The results contribute to understanding of the role played by a single complications.

Keywords: Birth weight; fetal growth; obstetric complications; pregnancy; shizophrenia


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About the article

Corresponding author: Prof. Giuseppe Bersani III Psychiatric Clinic, Department of Psychiatric Sciences and Psychological Medicine Special Service of Psychopharmacology and Psychosomatic Medicine University of Rome “La Sapienza” Viale dell'Università 30, 00185 Rome, Italy Tel.: +39-0649914591 Fax: +39-064454765

Received: May 9, 2006

Revised: September 8, 2006

Accepted: December 11, 2006

Published Online: 2007-03-07

Published in Print: 2007-04-01

Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2007.021. Export Citation

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