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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica

IMPACT FACTOR 2017: 1.558
5-year IMPACT FACTOR: 1.653

CiteScore 2017: 1.26

SCImago Journal Rank (SJR) 2017: 0.594
Source Normalized Impact per Paper (SNIP) 2017: 0.684

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Volume 35, Issue 2


Detection rate of Helicobacter pylori stool antigen in newborn infants and small children

Arne Stray-Pedersen / Peter Gaustad / Babill Stray-Pedersen
  • Department of Gynecology and Obstetrics, Rikshospitalet-Radiumhospitalet, University of Oslo, Norway
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Torleiv O. Rognum


Aims: To investigate the prevalence of H. pylori antigen in the stools of Norwegian neonates and small children.

Methods: A total of 249 children aged 0 days–3 years were tested for the presence of H. pylori antigen in feces using the HpSA immunoassay. For verification purposes, a selection of samples were analyzed with PCR targeting the 16 S rDNA Helicobacter gene.

Results:H. pylori antigen in stool was detected in 52% (36/69) of the neonates, in 15% (7/46) of infants aged 7 days–1 month, and in 5% (7/134) of children aged 1 month–3 years. In neonates, H. pylori antigen detection was significantly associated with mode of delivery: 59% (30/51) with uncomplicated vaginal births were HpSA positive compared to only 10% (1/10) of infants delivered by cesarean section (P=0.02). Positive PCR results were found in 35% (9/26) of HpSA positive samples. Sequencing of PCR products revealed 97–100% homology with gene sequences from both H. pylori and other Helicobacter species.

Conclusions: The low H. pylori antigen detection rate in children >1 month of age is in accordance with previous prevalence studies from Western countries. The unexpected finding of a high H. pylori antigen detection rate in neonates suggests that transient colonization may occur in the neonatal period.

Keywords: Helicobacter; HpSA; infants; infection; Norway; PCR; perinatal; prevalence; stool; transient colonization

About the article

Corresponding author: Dr. Arne Stray-Pedersen Institute of Forensic Medicine University of Oslo N-0027 Oslo Norway

Received: March 17, 2006

Revised: January 29, 2007

Accepted: February 1, 2007

Published in Print: 2007-04-01

Citation Information: Journal of Perinatal Medicine, Volume 35, Issue 2, Pages 155–158, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2007.040.

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