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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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Sequela of preterm versus term infants born to mothers on a methadone maintenance program: differential course of neonatal abstinence syndrome

Kevin Dysart1 / Hui-chen Hsieh2 / Karol Kaltenbach3 / Jay S. Greenspan4

1Department of Pediatrics, Thomas Jefferson University, Nemours Children's Clinics, Philadelphia, PA, USA

2Department of Pediatrics, Thomas Jefferson University, Nemours Children's Clinics, Philadelphia, PA, USA

3Department of Pediatrics, Thomas Jefferson University, Nemours Children's Clinics, Philadelphia, PA, USA

4Department of Pediatrics, Thomas Jefferson University, Nemours Children's Clinics, Philadelphia, PA, USA

Corresponding author. Kevin Dysart, MD Department of Pediatrics Thomas Jefferson University Nemours Children's Clinics Philadelphia, PA, USA Tel.: +1-215-955-0228, Fax: +1-215-923-9519

Citation Information: Journal of Perinatal Medicine. Volume 35, Issue 4, Pages 344–346, ISSN (Online) 03005577, ISSN (Print) 16193997, DOI: https://doi.org/10.1515/JPM.2007.063, July 2007

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Objective: We determined the effect of preterm delivery on the course of neonatal abstinence syndrome (NAS) in infants born to mothers participating in a methadone maintenance program.

Study design: A retrospective cohort study was conducted in which infant and maternal data were collected from the medical records of 53 preterm and 66 term infants. Infants were selected from all infants admitted to Thomas Jefferson University hospital born between 1998 and 2002 whose mothers were enrolled in the methadone maintenance program. All infants were managed by a standard protocol utilizing the Neonatal Abstinence Scoring System (NASS) and neonatal opiate solution (NOS). Preterm and term infants were compared.

Results: Preterm infants had shorter lengths of stay, treatment courses and required less medication than did term infants during the same time period.

Conclusion: These data indicate that following exposure to maternal methadone, preterm infants have a different neonatal course than do infants born at term.

Keywords: Methadone; NAS; neonate; preterm

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