Journal of Perinatal Medicine
Official Journal of the World Association of Perinatal Medicine
Editor-in-Chief: Dudenhausen, Joachim W.
Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland
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Obstetrical factors for death and brain injury among extremely-low-birth-weight infants
1Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan
2Center for Maternal, Fetal and Neonatal Medicine, Fukuoka University Hospital, Fukuoka, Japan
3Center for Maternal, Fetal and Neonatal Medicine, Fukuoka University Hospital, Fukuoka, Japan
4Center for Maternal, Fetal and Neonatal Medicine, Fukuoka University Hospital, Fukuoka, Japan
5Department of Public Health, School of Medicine, Fukuoka University, Fukuoka, Japan
6Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan
Citation Information: Journal of Perinatal Medicine. Volume 35, Issue 6, Pages 543–549, ISSN (Online) 16193997, ISSN (Print) 03005577, DOI: 10.1515/JPM.2007.111, December 2007
- Published Online:
Objective: To examine the obstetrical risk factors for death and brain injury among extremely-low-birth-weight (ELBW) infants (birth weight <1000 g).
Study design: Study subjects were 121 ELBW infants born at a single tertiary perinatal center. Death among ELBW infants was considered to have occurred when subjects died within their corrected age of 40 weeks. In the sub-analysis of the 91 ELBW infants who survived their corrected age of 40 weeks, brain injury was defined as present when criteria based on ultrasound and/or MRI were substantiated.
Results: A birth weight of <800 g [adjusted odds ratio (OR), 14.57; 95% confidence interval (CI), 4.72–56.98], a younger gestational age of <26 weeks (adjusted OR, 4.64; 95% CI, 1.60–14.90), and a low Apgar score of <5 (adjusted OR, 3.88; 95% CI, 1.32–12.45) were significantly associated with death among ELBW infants. A maternal age of 30 years or older (adjusted OR, 3.71; 95% CI, 1.19–13.35) was only associated with brain injury among surviving ELBW infants.
Conclusion: Obstetrical care should be aimed at preventing or predicting premature delivery especially at <26 weeks of gestation.
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