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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

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In This Section
Volume 36, Issue 1 (Jan 2008)


Genes and the preeclampsia syndrome

Sabine Mütze
  • 1Department of Obstetrics and Gynecology, Aachen University (RWTH), Aachen, Germany and Institute of Human Genetics, Aachen University (RWTH), Aachen, Germany
/ Sabine Rudnik-Schöneborn
  • 2Institute of Human Genetics, Aachen University (RWTH), Aachen, Germany
/ Klaus Zerres
  • 3Institute of Human Genetics, Aachen University (RWTH), Aachen, Germany
/ Werner Rath
  • 4Department of Obstetrics and Gynecology, Aachen University (RWTH), Aachen, Germany
Published Online: 2008-01-10 | DOI: https://doi.org/10.1515/JPM.2008.004


Preeclampsia is specific to pregnancy and is still a leading cause of maternal and perinatal mortality and morbidity, affecting about 3% of women, but the underlying pathogenetic mechanisms still remain unclear. Immune maladaptation, placental ischemia and increased oxidative stress represent the main components discussed to be of etiologic importance, and they all may have genetic implications. Since the familial nature of preeclampsia is known for many years, extensive research on the genetic contribution to the pathogenesis of this severe pregnancy disorder has been performed. In this review, we will overview the linkage and candidate gene studies carried out so far as well as summarize important historical notes on the genetic hypotheses generated in preeclampsia research. Moreover, the influence of maternal and fetal genes and their interaction as well as the role of genomic imprinting in preeclampsia will be discussed.

Keywords: Candidate genes; genetic susceptibility; linkage; preeclampsia

About the article

Corresponding author: Sabine Mütze, MD Institute of Human Genetics University of Technology (RWTH) Pauwelsstr. 30 D-52074 Aachen Germany Tel. (business): +49-241-80 88 107 Fax: +49-241-80 82 580

Received: 2007-07-27

Accepted: 2007-08-24

Published Online: 2008-01-10

Published in Print: 2008-01-01

Citation Information: Journal of Perinatal Medicine, ISSN (Online) 16193997, ISSN (Print) 03005577, DOI: https://doi.org/10.1515/JPM.2008.004.

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