Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Editorial Board: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Reiss, Irwin / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year


IMPACT FACTOR 2016: 1.577
5-year IMPACT FACTOR: 1.705

CiteScore 2016: 1.49

SCImago Journal Rank (SJR) 2016: 0.602
Source Normalized Impact per Paper (SNIP) 2016: 0.832

Online
ISSN
1619-3997
See all formats and pricing
More options …
Volume 36, Issue 1

Issues

Genes and the preeclampsia syndrome

Sabine Mütze
  • 1Department of Obstetrics and Gynecology, Aachen University (RWTH), Aachen, Germany and Institute of Human Genetics, Aachen University (RWTH), Aachen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sabine Rudnik-Schöneborn / Klaus Zerres / Werner Rath
Published Online: 2008-01-10 | DOI: https://doi.org/10.1515/JPM.2008.004

Abstract

Preeclampsia is specific to pregnancy and is still a leading cause of maternal and perinatal mortality and morbidity, affecting about 3% of women, but the underlying pathogenetic mechanisms still remain unclear. Immune maladaptation, placental ischemia and increased oxidative stress represent the main components discussed to be of etiologic importance, and they all may have genetic implications. Since the familial nature of preeclampsia is known for many years, extensive research on the genetic contribution to the pathogenesis of this severe pregnancy disorder has been performed. In this review, we will overview the linkage and candidate gene studies carried out so far as well as summarize important historical notes on the genetic hypotheses generated in preeclampsia research. Moreover, the influence of maternal and fetal genes and their interaction as well as the role of genomic imprinting in preeclampsia will be discussed.

Keywords: Candidate genes; genetic susceptibility; linkage; preeclampsia

About the article

Corresponding author: Sabine Mütze, MD Institute of Human Genetics University of Technology (RWTH) Pauwelsstr. 30 D-52074 Aachen Germany Tel. (business): +49-241-80 88 107 Fax: +49-241-80 82 580


Received: 2007-07-27

Accepted: 2007-08-24

Published Online: 2008-01-10

Published in Print: 2008-01-01


Citation Information: Journal of Perinatal Medicine, Volume 36, Issue 1, Pages 38–58, ISSN (Online) 16193997, ISSN (Print) 03005577, DOI: https://doi.org/10.1515/JPM.2008.004.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Abbas Mohammadpour-Gharehbagh, Batool Teimoori, Mehrnaz Narooei-nejad, Mehrnaz Mehrabani, Ramin Saravani, and Saeedeh Salimi
Journal of Cellular Biochemistry, 2017
[2]
Hannah E. J. Yong, Phillip E. Melton, Matthew P. Johnson, Katy A. Freed, Bill Kalionis, Padma Murthi, Shaun P. Brennecke, Rosemary J. Keogh, Eric K. Moses, and Kartik Shankar
PLOS ONE, 2015, Volume 10, Number 5, Page e0128230
[3]
Penghua Yang, Aihua Dai, Andrei P. Alexenko, Yajun Liu, Amanda J. Stephens, Laura C. Schulz, Danny J. Schust, R. Michael Roberts, Toshihiko Ezashi, and Barbara T. Alexander
PLoS ONE, 2014, Volume 9, Number 7, Page e103110
[4]
Agnieszka Seremak-Mrozikiewicz, Anna Bogacz, Donata Deka-Pawlik, Andrzej Klejewski, Hubert Wolski, Krzysztof Drews, Monika Karasiewicz, and Boguslaw Czerny
The Journal of Maternal-Fetal & Neonatal Medicine, 2017, Volume 30, Number 20, Page 2498
[5]
A.G.M. Aya, B. Ondze, J. Ripart, and P. Cuvillon
Anaesthesia Critical Care & Pain Medicine, 2016, Volume 35, Page S13
[6]
Linlu Zhao, Elizabeth W Triche, Kyle M Walsh, Michael B Bracken, Audrey F Saftlas, Josephine Hoh, and Andrew T Dewan
BMC Pregnancy and Childbirth, 2012, Volume 12, Number 1
[7]
P. J. Correa, Y. Palmeiro, M. J. Soto, C. Ugarte, and S. E. Illanes
Hypertension in Pregnancy, 2016, Volume 35, Number 3, Page 280
[8]
L. V. Akulenko, S. G. Tcakhilova, A. V. Dzansolova, D. H. Sarahova, F. B. Kokoeva, and M. E. Kravtsova
Problemy reproduktsii, 2015, Volume 21, Number 1, Page 8
[9]
Hélène Letur, Maëliss Peigné, Jeanine Ohl, Isabelle Cédrin-Durnerin, Emmanuelle Mathieu-D’Argent, Florence Scheffler, Veronika Grzegorczyk-Martin, and Jacques de Mouzon
Fertility and Sterility, 2016, Volume 106, Number 2, Page 284
[10]
Agata Sakowicz, Paulina Hejduk, Tadeusz Pietrucha, Magdalena Nowakowska, Elżbieta Płuciennik, Karolina Pospiech, Agnieszka Gach, Magda Rybak-Krzyszkowska, Bartosz Sakowicz, Marek Kaminski, Grzegorz Krasomski, and Lidia Biesiada
American Journal of Obstetrics and Gynecology, 2016, Volume 214, Number 4, Page 538.e1
[11]
Agnieszka Seremak-Mrozikiewicz, Anna Bogacz, Joanna Bartkowiak-Wieczorek, Hubert Wolski, Boguslaw Czerny, Malgorzata Gorska-Paukszta, and Krzysztof Drews
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2015, Volume 188, Page 113
[12]
Quaker E. Harmon, Stephanie M. Engel, Michael C. Wu, Thomas M. Moran, Jingchun Luo, Alison M. Stuebe, Christy L. Avery, and Andrew F. Olshan
American Journal of Reproductive Immunology, 2014, Volume 71, Number 5, Page 472
[13]
Saeedeh Salimi, Mohsen Saravani, Minoo Yaghmaei, Zeinab Fazlali, Mojgan Mokhtari, Anoosh Naghavi, and Farzaneh Farajian-Mashhadi
Archives of Gynecology and Obstetrics, 2015, Volume 291, Number 6, Page 1303
[14]
L.C. Ferreira, C.E.M. Gomes, A.C.P. Araújo, P.F. Bezerra, P. Duggal, and S.M.B. Jeronimo
Placenta, 2015, Volume 36, Number 2, Page 186
[15]
Y.H. Lee, J.-H. Kim, and G.G. Song
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2014, Volume 182, Page 202
[16]
Helen L. Barrett, Marloes Dekker Nitert, H. David McIntyre, and Leonie K. Callaway
Hypertension in Pregnancy, 2014, Volume 33, Number 4, Page 508
[17]
Elizabeth W. Triche, Alper Uzun, Andrew T. DeWan, Itsuka Kurihara, Joy Liu, Rachel Occhiogrosso, Burton Shen, Jeremy Parker, and James F. Padbury
Obstetrics & Gynecology, 2014, Volume 123, Number 6, Page 1155
[18]
C. Geyl, E. Clouqueur, J. Lambert, D. Subtil, V. Debarge, and P. Deruelle
Gynécologie Obstétrique & Fertilité, 2014, Volume 42, Number 4, Page 229
[19]
H.E.J. Yong, P. Murthi, A. Borg, B. Kalionis, E.K. Moses, S.P. Brennecke, and R.J. Keogh
Placenta, 2014, Volume 35, Number 2, Page 117
[20]
Caroline Abrão Dalmáz, Kátia Gonçalves dos Santos, Mariana Rodrigues Botton, and Israel Roisenberg
Revista da Associação Médica Brasileira, 2011, Volume 57, Number 6, Page 692
[21]
T. Groten, E. Schleussner, T. Lehmann, F. Reister, B. Holzer, K. A. Danso, and R. Zeillinger
Archives of Gynecology and Obstetrics, 2014, Volume 289, Number 3, Page 581
[22]
Caroline Abrão Dalmáz, Kátia Gonçalves dos Santos, Mariana Rodrigues Botton, and Israel Roisenberg
Revista da Associação Médica Brasileira (English Edition), 2011, Volume 57, Number 6, Page 678
[23]
Gwan Gyu Song, Jae-Hoon Kim, and Young Ho Lee
Immunological Investigations, 2013, Volume 42, Number 8, Page 749
[24]
James S. Betoni, Kimberly Derr, Matthew C. Pahl, Laura Rogers, Corinna L. Muller, Roger E. Packard, David J. Carey, Helena Kuivaniemi, and Gerard Tromp
Hypertension in Pregnancy, 2013, Volume 32, Number 4, Page 321
[25]
E. Conti, L. Zezza, E. Ralli, D. Caserta, M.B. Musumeci, M. Moscarini, C. Autore, and M. Volpe
Cytokine & Growth Factor Reviews, 2013, Volume 24, Number 5, Page 411
[26]
Mary L. Rosser and Nadine T. Katz
Advances in Chronic Kidney Disease, 2013, Volume 20, Number 3, Page 287
[27]
Caroline Abrão Dalmáz, Kátia Gonçalves dos Santos, Mariana Rodrigues Botton, and Israel Roisenberg
Revista da Associação Médica Brasileira, 2011, Volume 57, Number 6, Page 678
[28]
W. Rath and C. J. Thaler
Hämostaseologie, 2013, Volume 33, Number 1, Page 21
[29]
[30]
L. Zhao, M. B. Bracken, A. T. DeWan, and S. Chen
Molecular Human Reproduction, 2013, Volume 19, Number 3, Page 136
[31]
Ulrich Abildgaard and Ketil Heimdal
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2013, Volume 166, Number 2, Page 117
[32]
D. A. Loisel, C. Billstrand, K. Murray, K. Patterson, T. Chaiworapongsa, R. Romero, and C. Ober
Molecular Human Reproduction, 2013, Volume 19, Number 3, Page 144
[33]
JACOB A. LYKKE, LANCE A. BARE, JØRN OLSEN, ROBERT LAGIER, CARMEN TONG, ANDRE ARELLANO, MICHAEL J. PAIDAS, and JENS LANGHOFF-ROOS
Acta Obstetricia et Gynecologica Scandinavica, 2012, Volume 91, Number 9, Page 1053
[34]
Linlu Zhao, Andrew T. DeWan, and Michael B. Bracken
The Journal of Maternal-Fetal & Neonatal Medicine, 2012, Volume 25, Number 12, Page 2676
[35]
Reza Ahmadi, Zohreh Rahimi, Asad Vaisi-Raygani, Amir Kiani, Nasrin Jalilian, and Ziba Rahimi
Hypertension in Pregnancy, 2012, Volume 31, Number 4, Page 405
[36]
Reem Mustafa, Sana Ahmed, Anu Gupta, and Rocco C. Venuto
Journal of Pregnancy, 2012, Volume 2012, Page 1
[37]
A. Atis, O. Oruc, Y. Aydin, U. Cetincelik, and N. Goker
International Journal of Immunogenetics, 2012, Volume 39, Number 3, Page 241
[38]
Ceyhun Bereketoğlu, Mülkiye Kasap, and Ayfer Pazarbaşı
Journal of Pregnancy, 2012, Volume 2012, Page 1
[39]
L. Massey Skatulla, S. Loibl, B. Schauf, and T. Müller
Archives of Gynecology and Obstetrics, 2012, Volume 286, Number 1, Page 89
[40]
E. Reyna-Villasmil, J. Mejía-Montilla, N. Reyna-Villasmil, D. Torres-Cepeda, J. Santos-Bolíva, and J. Perozo-Romero
Clínica e Investigación en Ginecología y Obstetricia, 2013, Volume 40, Number 1, Page 15
[41]
Francisco J. Valenzuela, Alejandra Pérez-Sepúlveda, María J. Torres, Paula Correa, Gabriela M. Repetto, and Sebastián E. Illanes
Journal of Pregnancy, 2012, Volume 2012, Page 1
[42]
Yves Giguère, Marc Charland, Sébastien Thériault, Emmanuel Bujold, Mélissa Laroche, François Rousseau, Julie Lafond, and Jean-Claude Forest
Clinical Chemistry and Laboratory Medicine, 2012, Volume 50, Number 6
[43]
Alexandra Muravská, Anna Germanová, Marie Jáchymová, Zdeněk Hájek, Jana Švarcová, Tomáš Zima, and Marta Kalousová
Clinical Biochemistry, 2011, Volume 44, Number 17-18, Page 1380
[44]
E. Reyna, J. Mejía, N. Reyna, D. Torres, J. Santos, and J. Perozo
Clínica e Investigación en Ginecología y Obstetricia, 2011, Volume 38, Number 6, Page 229
[45]
Giovanna Ogge, Tinnakorn Chaiworapongsa, Roberto Romero, Youssef Hussein, Juan Pedro Kusanovic, Lami Yeo, Chong Jai Kim, and Sonia S. Hassan
Journal of Perinatal Medicine, 2011, Volume 39, Number 6
[46]
Shagun Aggarwal, Nalini Dimri, Indu Tandon, and Sarita Agarwal
Journal of Obstetrics and Gynaecology Research, 2011, Volume 37, Number 10, Page 1335
[47]
Paula J. Williams and Fiona Broughton Pipkin
Best Practice & Research Clinical Obstetrics & Gynaecology, 2011, Volume 25, Number 4, Page 405
[48]
Isha Agarwal and S. Ananth Karumanchi
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2011, Volume 1, Number 1, Page 17
[49]
O. Balta, A. Boztosun, K. Deveci, S. Gulturk, F. Ekici, A. Kaya, A. Cetin, and M. Cetin
Placenta, 2011, Volume 32, Number 9, Page 675
[50]
H.K. Ng, B. Novakovic, S. Hiendleder, J.M. Craig, C.T. Roberts, and R. Saffery
Placenta, 2010, Volume 31, Number 4, Page 259
[51]
D. Marzioni, T. Todros, S. Cardaropoli, A. Rolfo, T. Lorenzi, P. Ciarmela, R. Romagnoli, L. Paulesu, and M. Castellucci
Placenta, 2010, Volume 31, Number 10, Page 919
[52]
T. Lorenzi, D. Marzioni, S. Giannubilo, A. Quaranta, C. Crescimanno, A. De Luca, A. Baldi, T. Todros, A.L. Tranquilli, and M. Castellucci
Placenta, 2009, Volume 30, Number 1, Page 35
[53]
L. T. Roten, M. H. Fenstad, S. Forsmo, M. P. Johnson, E. K. Moses, R. Austgulen, and F. Skorpen
Molecular Human Reproduction, 2011, Volume 17, Number 7, Page 439
[54]
Eric AP Steegers, Peter von Dadelszen, Johannes J Duvekot, and Robert Pijnenborg
The Lancet, 2010, Volume 376, Number 9741, Page 631
[55]
Zahra Anvar, Bahia Namavar-Jahromi, and Mostafa Saadat
Archives of Gynecology and Obstetrics, 2011, Volume 283, Number S1, Page 5
[56]
M. Centlow, C. Wingren, C. Borrebaeck, M. J. Brownstein, and S. R. Hansson
Journal of Pregnancy, 2011, Volume 2011, Page 1
[57]
Kalliopi I. Pappa, Maria Roubelakis, George Vlachos, Spyros Marinopoulos, Antonia Zissou, Nicholas P. Anagnou, and Aris Antsaklis
The Journal of Maternal-Fetal & Neonatal Medicine, 2011, Volume 24, Number 4, Page 628
[58]
Chengjuan Sun, Ying Chen, Weiyuan Zhang, and Song Yu
Journal of Perinatal Medicine, 2009, Volume 37, Number 1
[59]
Giovanni Larciprete, Federica Rossi, Therese Deaibess, Letizia Brienza, Giulia Barbati, Elisabetta Romanini, Stefano Gioia, and Elio Cirese
Journal of Obstetrics and Gynaecology Research, 2010, Volume 36, Number 5, Page 996
[60]
Bernard J. Crespi
Annals of the New York Academy of Sciences, 2010, Volume 1206, Number 1, Page 80
[61]
Leea Keski-Nisula, Seppo Heinonen, Sami Remes, and Juha Pekkanen
American Journal of Reproductive Immunology, 2009, Volume 62, Number 5, Page 293
[62]
H. Peterson, H. Laivuori, E. Kerkela, H. Jiao, L. Hiltunen, S. Heino, I. Tiala, S. Knuutila, V. Rasi, J. Kere, and K. Kivinen
Molecular Human Reproduction, 2009, Volume 15, Number 7, Page 443

Comments (0)

Please log in or register to comment.
Log in