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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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CiteScore 2016: 1.49

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Volume 36, Issue 2 (Mar 2008)


Mortality and morbidity of neonates born at <26 weeks of gestation (1998–2003). A population-based study

Eva Landmann / Björn Misselwitz / Jens O. Steiss / Ludwig Gortner
  • 4Department of General Pediatrics and Neonatology, Saarland University Children's Hospital, Homburg/Saar, Germany
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Published Online: 2008-03-10 | DOI: https://doi.org/10.1515/JPM.2008.016


Objective: To describe mortality and morbidity of neonates born at <26 weeks' gestation in a contemporary population-based cohort.

Methods: We analyzed data of neonates born at <26 weeks between 1998 and 2003 in the Federal State of Hesse, Germany. Survival was calculated at 28 days and at discharge from hospital.

Results: Out of a total of 800 births, 572 infants were liveborn. Among those admitted for neonatal intensive care, 62.3% survived until day 28. Among the neonates followed until death or discharge, 59.6% were discharged home. Logistic regression analyses showed the following variables to be associated with an increased risk of death: Twins (Odds Ratio (OR) 3.7; 95% Confidence Interval (CI) 1.34–10.26), multiple birth ≥3 (OR 8.14; CI 1.23–53.86), intraventricular hemorrhage (IVH) ≥grade III (OR 4.79; CI 1.89–12.14), clinical risk index for babies score >15 (OR 2.9; CI 1.09–7.76), and a gestational age ≤23 weeks (OR 5.34; CI 1.24–22.98). Among infants discharged home, bronchopulmonary dysplasia was diagnosed in 52.2%, IVH ≥grade III and/or periventricular leukomalacia in 15%, and severe retinopathy of prematurity in 29.8%.

Conclusions: This study provides outcome data derived from a contemporary population-based cohort. Mortality and complication rates remain high.

Keywords: Bronchopulmonary dysplasia; intraventricular hemorrhage; neonatal survival; preterm infants

About the article

Corresponding author: Eva Landmann, MD, MPH Pediatric Center Department of Pediatrics and Neonatology Feulgenstrasse 12 35392 Giessen/Germany

Received: 2007-05-24

Revised: 2007-10-27

Accepted: 2007-11-12

Published Online: 2008-03-10

Published Online: 2008-02-08

Published in Print: 2008-03-01

Citation Information: Journal of Perinatal Medicine, ISSN (Online) 16193997, ISSN (Print) 03005577, DOI: https://doi.org/10.1515/JPM.2008.016.

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