Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Reiss, Irwin / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year

IMPACT FACTOR 2016: 1.577
5-year IMPACT FACTOR: 1.705

CiteScore 2016: 1.49

SCImago Journal Rank (SJR) 2016: 0.602
Source Normalized Impact per Paper (SNIP) 2016: 0.832

See all formats and pricing
More options …
Volume 36, Issue 2 (Mar 2008)


Prenatal long-chain polyunsaturated fatty acid status: the importance of a balanced intake of docosahexaenoic acid and arachidonic acid

Mijna Hadders-Algra
  • 1Department of Paediatrics – Developmental Neurology, University Medical Center Groningen, Groningen, The Netherlands
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2008-03-10 | DOI: https://doi.org/10.1515/JPM.2008.029


This review addresses the effect of prenatal long-chain polyunsaturated fatty acid (LCPUFA) status on neurodevelopmental outcome. It focuses on the major LPCUFA doxosahexaenoic acid (DHA; 22:6ω3) and arachidonic acid (AA; 20:4ω6). Due to enzymatic competition high DHA intake results in lower tissue levels of AA.

LCPUFA accumulation in the brain starts early and increases during the third trimester. Initially brain AA-accretion exceeds DHA-accretion; after term age DHA-accretion surpasses AA-accretion.

Animal studies indicated that early ω3-depletion results in poorer developmental outcome. They also showed that early ω3-supplementation had no effect on cognitive outcome, promotes visual development and impairs auditory and motor development. Only limited human data are available. Correlational studies suggest that neonatal AA status shows a positive relation with early neurodevelopmental outcome and that neonatal DHA status also might be correlated with improved outcome beyond infancy. Results of human intervention studies are equivocal: most studies were unable to demonstrate a positive effect of prenatal ω3-supplementation.

It is concluded that only limited evidence exists to support the notion that prenatal ω3-supplementation favours developmental outcome. Caution is warranted for an unbalanced high DHA intake during the first two trimesters of pregnancy, i.e., DHA without additional AA supplementation.

Keywords: Arachidonic acid; brain development; doxosahexaenoic acid; LCPUFA; neurodevelopmental outcome; prenatal nutrition; pregnancy; review; trans-fatty acids

About the article

Corresponding author: Mijna Hadders-Algra, MD, PhD Developmental Neurology University of Groningen Medical Centre Hanzeplein 1 9713 GZ Groningen The Netherlands Tel.: +31 50 361 9158 Fax: +31 50 363 6905

Published Online: 2008-03-10

Published Online: 2008-01-23

Published in Print: 2008-03-01

Citation Information: Journal of Perinatal Medicine, ISSN (Online) 16193997, ISSN (Print) 03005577, DOI: https://doi.org/10.1515/JPM.2008.029.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Alireza Ostadrahimi, Hanieh Salehi-pourmehr, Sakineh Mohammad-Alizadeh-Charandabi, Seifollah Heidarabady, and Azizeh Farshbaf-Khalili
European Journal of Nutrition, 2017
Khadiga S Ibrahim and Eman M El-Sayed
Toxicology and Industrial Health, 2013, Volume 29, Number 4, Page 367
JodiAnne T. Wood, John S. Williams, Lakshmipathi Pandarinathan, David R. Janero, Carol J. Lammi-Keefe, and Alexandros Makriyannis
Journal of Lipid Research, 2010, Volume 51, Number 6, Page 1416
M.W. Church, K.-L.C. Jen, J.I. Anumba, D.A. Jackson, B.R. Adams, and J.W. Hotra
Neurotoxicology and Teratology, 2010, Volume 32, Number 2, Page 171
Kevin Hadley, Alan Ryan, Stewart Forsyth, Sheila Gautier, and Norman Salem
Nutrients, 2016, Volume 8, Number 4, Page 216
Indu Mani, Pratibha Dwarkanath, Tinku Thomas, Annamma Thomas, and Anura V Kurpad
International Journal of Epidemiology, 2016, Volume 45, Number 2, Page 523
E. Yakes Jimenez, C. Mangani, P. Ashorn, W.S. Harris, K. Maleta, and K.G. Dewey
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2015, Volume 95, Page 71
Jolien Steenweg-de Graaff, Henning Tiemeier, Régine P.M. Steegers-Theunissen, Albert Hofman, Vincent W.V. Jaddoe, Frank C. Verhulst, and Sabine J. Roza
Clinical Nutrition, 2014, Volume 33, Number 1, Page 115
Lynette K. Rogers, Christina J. Valentine, and Sarah A. Keim
Pharmacological Research, 2013, Volume 70, Number 1, Page 13
Developmental Medicine & Child Neurology, 2012, Volume 54, Number 12, Page 1102
Adam C. Dziorny, Mark S. Orlando, J.J. Strain, Philip W. Davidson, and Gary J. Myers
NeuroToxicology, 2013, Volume 38, Page 147
L.-T. C huang, U. Bülbül, P.-C. Wen, R.H. Glew, and F.A. Ayaz
Journal of Food Science, 2012, Volume 77, Number 5, Page C512
K.-G. Sabel, B. Strandvik, M. Petzold, and C. Lundqvist-Persson
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2012, Volume 86, Number 4-5, Page 183
Andrea Lo, Julianna Sienna, Eva Mamak, Nada Djokanovic, Carol Westall, and Gideon Koren
Obstetrics and Gynecology International, 2012, Volume 2012, Page 1
Joachim W. Dudenhausen, Amos Grunebaum, and Ursula M. Staudinger
Journal of Perinatal Medicine, 2013, Volume 41, Number 1
C.E.H. Dirix, G. Hornstra, and J.G. Nijhuis
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2009, Volume 80, Number 4, Page 207
Jinping Zhao, Marc R. Del Bigio, and Hope A. Weiler
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2009, Volume 81, Number 5-6, Page 349
Jinping Zhao, Marc R. Del Bigio, and Hope A. Weiler
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2011, Volume 84, Number 1-2, Page 63
S.A. van Goor, A. Schaafsma, J.J.H.M. Erwich, D.A.J. Dijck-Brouwer, and F.A.J. Muskiet
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2010, Volume 82, Number 1, Page 15
Saskia A. van Goor, D.A. Janneke Dijck-Brouwer, Jan Jaap H.M Erwich, Anne Schaafsma, and Mijna Hadders-Algra
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2011, Volume 84, Number 5-6, Page 139
Cristina Lundqvist-Persson, Gerd Lau, Per Nordin, Birgitta Strandvik, and Karl-Göran Sabel
Early Human Development, 2010, Volume 86, Number 7, Page 407
Christina J. Valentine, Georgia Morrow, Soledad Fernandez, Parul Gulati, Dennis Bartholomew, Don Long, Stephen E. Welty, Ardythe L. Morrow, and Lynette K. Rogers
The Journal of Pediatrics, 2010, Volume 157, Number 6, Page 906
Berthold Koletzko
Journal of Perinatal Medicine, 2008, Volume 36, Number 3
Hormoz Azizian, John K. G. Kramer, Shannon Ehler, and Jonathan M. Curtis
European Journal of Lipid Science and Technology, 2010, Volume 112, Number 4, Page 452
Saskia A. van Goor, D. A. Janneke Dijck-Brouwer, Bennard Doornbos, Jan Jaap H. M. Erwich, Anne Schaafsma, Frits A. J. Muskiet, and Mijna Hadders-Algra
British Journal of Nutrition, 2010, Volume 103, Number 02, Page 235
Rosa Alati, Kate Van Dooren, Jake M. Najman, Gail M. Williams, and Alexandra Clavarino
Addiction, 2009, Volume 104, Number 8, Page 1324
Jing Li, Yawei Fan, Zhiwu Zhang, Hai Yu, Yin An, John K. G. Kramer, and Zeyuan Deng
Lipids, 2009, Volume 44, Number 3, Page 257

Comments (0)

Please log in or register to comment.
Log in