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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, Ivica

9 Issues per year

IMPACT FACTOR 2017: 1.558
5-year IMPACT FACTOR: 1.653

CiteScore 2017: 1.26

SCImago Journal Rank (SJR) 2017: 0.594
Source Normalized Impact per Paper (SNIP) 2017: 0.684

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Volume 36, Issue 4


The role of antioxidant vitamins in hypertensive disorders of pregnancy

Olivera Kontic-Vucinic / Milan Terzic / Nebojsa Radunovic
Published Online: 2008-07-03 | DOI: https://doi.org/10.1515/JPM.2008.063


Preeclampsia (PE) is an important and a leading cause of both maternal morbidity and adverse perinatal outcomes. Despite progress in perinatal medicine for patients with an established diagnosis of PE, a therapeutic approach other than termination of pregnancy was unsuccessful. Women predisposed to PE begin pregnancy with a certain degree of endothelial dysfunction, a lesion that precedes shallow placentation. The proposed sequence of events comprises endothelial dysfunction, defective trophoblast invasion, and consequential impaired placental perfusion, immune maladaptation and inflammation. The possible link between these could be oxidative stress by excessive production of reactive oxygen species coupled with inadequate or overwhelmed antioxidant defense mechanisms. These defense mechanisms, involving antioxidant vitamins and enzyme systems, may restrain the extent of damage caused by oxidative stress. Markers of oxidative stress in women with established PE were confirmed. Accordingly, these findings support an expected beneficial effect of antioxidant therapy in the prevention of PE and other pregnancy-related disorders. Numerous studies have been carried out in order to investigate this possible and simple prophylactic and/or therapeutic approach in prevention of oxidative stress and eventual reduction of PE and its perinatal complications. In this review the role of vitamin antioxidants in prevention and treatment of PE is discussed. Despite the logic behind using antioxidant vitamins, the data, thus far, are at best conflicting.

Keywords: Antioxidative vitamins; hypertensive disorders; preeclampsia; pregnancy

About the article

Corresponding author: Associate Professor Dr. Olivera Kontic-Vucinic, MD, PhD, Ob/Gyn Department of Obstetrics and Gynecology School of Medicine University of Belgrade Visegradska 26 11000 Belgrade Serbia Tel: +381 11 361 55 92 Fax: +381 11 361 56 03

Received: 2007-10-26

Revised: 2008-04-06

Accepted: 2008-04-10

Published Online: 2008-07-03

Published in Print: 2008-07-01

Citation Information: Journal of Perinatal Medicine, Volume 36, Issue 4, Pages 282–290, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2008.063.

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