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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica

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IMPACT FACTOR 2017: 1.558
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CiteScore 2017: 1.26

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Source Normalized Impact per Paper (SNIP) 2017: 0.684

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Volume 36, Issue 5


A randomized trial of tight vs. less tight control of mild essential and gestational hypertension in pregnancy

Alaa A. El Guindy / Ashraf F. Nabhan
Published Online: 2008-06-12 | DOI: https://doi.org/10.1515/JPM.2008.060


Objectives: To assess the effects of applying a tight vs. a less tight control of mild chronic essential or gestational non-proteinuric hypertension in pregnancy.

Methods: A randomized trial was conducted in 2006–2007 in the University of Ain Shams, Egypt. Eligible participants (n=125) were randomly assigned to either tight or less tight control of mild chronic (essential) or gestational (non-proteinuric) hypertension. The primary outcome measure was the development of severe hypertension during follow-up. Analysis was by intention-to-treat.

Results: In the tight target group, adjustment of the dose with an increment of 191 mg yielded a mean dose of methyldopa of 1267±406 mg. Both systolic and diastolic BP levels were significantly less than in the tight target group. More women in the less tight group had severe hypertension during follow up (RR 3.167 and 95% CI 1.36–7.37). The rate of antenatal hospitalization was significantly higher in the less tight target group with a relative risk of 2.57 and 95% CI 1.16–5.70. The gestational age at delivery was significantly better in the tight target group. Preterm delivery and birth weight were not significantly different between the study groups.

Conclusion: Tight control of blood pressure reduces the rate of antenatal hospitalization and does not adversely affect perinatal outcomes in women with mild essential or gestational hypertension.

Keywords: Hypertension; pregnancy; prognosis; random allocation; therapy; tight control

About the article

Corresponding author: Ashraf Fawzy Nabhan 50 Khalifa Almaamoun Street Clinic 509 Heliopolis Cairo Egypt Tel.: +202 26357966 Fax: +202 22595775

Received: 2007-10-03

Revised: 2008-02-26

Accepted: 2008-04-09

Published Online: 2008-06-12

Published Online: 2008-06-12

Published in Print: 2008-09-01

Citation Information: Journal of Perinatal Medicine, Volume 36, Issue 5, Pages 413–418, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2008.060.

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