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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year

IMPACT FACTOR increased in 2015: 1.798
Rank 46 out of 120 in category Pediatrics in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.731
Source Normalized Impact per Paper (SNIP) 2014: 0.687
Impact per Publication (IPP) 2014: 1.483

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Volume 36, Issue 6 (Nov 2008)


Long-term epidural block treatment in patients with early threatening preterm delivery and vaginal fetal engagement

Birgit Arabin
  • 1Department of Perinatology, Isala Kliniken, Zwolle, The Netherlands
/ Karel Kuizenga
  • 2Department of Anaesthesiology, Isala Kliniken, Zwolle, The Netherlands
/ Diny V. Zveren
  • 3Department of Neonatology, Isala Kliniken, Zwolle, The Netherlands
/ Jim V. Eyck
  • 4Department of Perinatology, Isala Kliniken, Zwolle, The Netherlands
Published Online: 2008-07-29 | DOI: https://doi.org/10.1515/JPM.2008.081


We report on an exceptional therapy with epidural anesthesia and tunnelling of the peridural catheter over a time period of 2–14 days in patients with threatening early preterm labor, intact membranes and vaginal engagement of the infants (4 singleton, 8 twin and 2 triplet pregnancies). A combination of bupivacaine (0.125%) and fentanyl (2 μg/mL) was used up to a maximum of 20 mL/h during the treatment period. Long-term follow-up of the infants was normal in 19/20 infants. The advantages, such as prolongation of pregnancy without maternal pain and disadvantages such as the risk of fetal and maternal infection and of sudden delivery are discussed. The online version of the Journal (see http://dx.doi.org/10.1515/jpm.2008.081_supp-1) allows video illustrations of a triplet pregnancy, in which the first triplet was born after one week of epidural anesthesia and the pregnancy continued under epidural anesthesia for the remaining two triplets staying with intact membranes in the vagina (delayed interval delivery) for six more days. The results of this pilot series suggest that prolongation of these pregnancies under epidural anesthesia might be an option in exceptional cases when viability is questionable or when corticosteroid therapy is desired before final delivery. Further evaluation of this strategy is needed but only in tertiary centers with 24-h presence of qualified obstetric and neonatal care and intensive surveillance.

This article offers supplementary material which is provided at the end of the article.

Keywords: Epidural anesthesia; outcome of preterm infants; pain during labor; preterm delivery; prolongation of pregnancy

About the article

Corresponding author: Birgit Arabin, MD Clara Angela Foundation Institute for Research Development A. Herrenhausenstr. 44 58455 Witten/Germany

Received: 2008-03-01

Revised: 2008-04-24

Accepted: 2008-05-19

Published Online: 2008-07-29

Published Online: 2008-07-31

Published in Print: 2008-11-01

Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2008.081. Export Citation

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