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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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Impact per Publication (IPP) 2014: 1.483

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National screening program vs. standardized neurodevelopmental follow-up

Cornelia Maschke1 / Birte Ellenrieder2 / Kurt Hecher3 / Peter Bartmann4

1Department of Neonatology, University Children's Hospital, Bonn, Germany

2Department of Neonatology, University Children's Hospital, Bonn, Germany

3Department of Obstetrics and Fetal Medicine, University Medical Center, Hamburg-Eppendorf, Germany

4Department of Neonatology, University Children's Hospital, Bonn, Germany

Corresponding author: Cornelia Maschke, MD Department of Neonatology University Children's Hospital Adenauerallee 119 53113 Bonn, Germany Tel.: +49-228-287-33408 Fax: +49-228-287-33296

Citation Information: Journal of Perinatal Medicine. Volume 37, Issue 1, Pages 87–90, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/JPM.2009.008, September 2008

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Background: Long-term follow-up is urgently needed to decide on the consequences of new therapies.

Objective: This study assesses the use of a national child development screening program for a follow-up examination of a defined patient group.

Patients and methods: Neurodevelopmental outcome of 139 survivors after intrauterine laser coagulation for severe twin-twin transfusion syndrome was investigated both according to a standardized neurodevelopmental follow-up and according to the pediatricians' screening examinations.

Results: Screening and standardized tests revealed identical results in 90.6% of the cases. Using the national screening program only four out of 139 children (2.9%) with minor neurological disabilities would have been missed. For identifying mild or severe neurodevelopmental abnormalities the screening has a sensivity of 78% and a specifity of 93%. The positive predictive value is 61% and the negative predictive value 97%.

Conclusions: The use of already available and established follow-up programs for extended follow-up studies would considerably reduce costs, time and manpower.

Keywords: Laser coagulation; neurodevelopmental follow-up; preterm infant; screening examinations; twin-twin transfusion syndrome

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