Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


IMPACT FACTOR 2018: 1.361
5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

SCImago Journal Rank (SJR) 2018: 0.522
Source Normalized Impact per Paper (SNIP) 2018: 0.602

Online
ISSN
1619-3997
See all formats and pricing
More options …
Volume 37, Issue 1

Issues

High cytomegalovirus IgG avidity is a reliable indicator of past infection in patients with positive IgM detected during the first trimester of pregnancy

Bibi Kanengisser-Pines
  • 1Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Affiliated with the Hadassah-Hebrew University School of Medicine, Jerusalem, Israel
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Yenon Hazan
  • 2Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Affiliated with the Hadassah-Hebrew University School of Medicine, Jerusalem, Israel
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Guy Pines
  • 3Department of Surgery B, Kaplan Medical Center, Rehovot, Affiliated with the Hadassah-Hebrew University School of Medicine, Jerusalem, Israel
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Zvi Appelman
  • 4Clinical Genetics Unit, Kaplan Medical Center, Rehovot, Affiliated with the Hadassah-Hebrew University School of Medicine, Jerusalem, Israel
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2008-08-04 | DOI: https://doi.org/10.1515/JPM.2009.012

Abstract

Objective: To evaluate the accuracy of high cytomegalovirus (CMV) specific IgG avidity in excluding recent infection in patients with anti-CMV IgM antibodies detected during the first trimester, using amniotic fluid obtained by standard amniocentesis.

Methods: Records of all patients with a positive anti-CMV IgM with IgG avidity >65% detected during pregnancy were reviewed. Amniocentesis for CMV assessment was offered to all patients. The presence of the virus in amniotic fluid was determined by polymerase chain reaction (PCR) and shell vial testing.

Results: Seventy-nine patients with a positive CMV IgM-high IgG avidity combination were identified. The serological tests were performed during the first trimester in 65 (82.3%) patients, of which 28 consented and underwent amniocentesis. All amniotic fluid samples were negative for CMV-PCR and CMV shell vial testing.

Conclusions: IgG avidity above 65% is a good indicator of past infection, and thus excludes CMV in the amniotic fluid. In such circumstances, invasive prenatal diagnosis may eventually not be required. This optimistic conclusion, however, needs to be confirmed by large scale studies.

Keywords: Amniotic fluid; avidity; cytomegalovirus; infection; pregnancy

About the article

Corresponding author: Bibi Kanengisser, MD Department of Obstetrics and Gynecology Kaplan Medical Center POB 1, Rehovot 76100, Israel Tel.: +972-8-9441384 Fax: +972-8-9441765 Cellular: +972-54-7740717


Received: 2008-04-15

Revised: 2008-06-05

Accepted: 2008-06-23

Published Online: 2008-08-04

Published Online: 2008-08-04

Published in Print: 2009-01-01


Citation Information: Journal of Perinatal Medicine, Volume 37, Issue 1, Pages 15–18, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2009.012.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Bharat S. Parekh, Chin-Yih Ou, Peter N. Fonjungo, Mireille B. Kalou, Erin Rottinghaus, Adrian Puren, Heather Alexander, Mackenzie Hurlston Cox, and John N. Nkengasong
Clinical Microbiology Reviews, 2018, Volume 32, Number 1
[2]
Harry E. Prince, Mary Lapé-Nixon, and C. J. Papasian
Clinical and Vaccine Immunology, 2014, Volume 21, Number 10, Page 1377
[3]
N. Mayooran, E. O'Cathain, M. N. Bresnihan, and N. Patil
Case Reports, 2015, Volume 2015, Number jan20 1, Page bcr2014206505
[4]
Gisela Enders, Anja Daiminger, Ursula Bäder, Simone Exler, Yvonne Schimpf, and Martin Enders
Journal of Clinical Virology, 2013, Volume 56, Number 2, Page 102
[5]
Chih-Ping Chen, Yi-Ning Su, Schu-Rern Chern, Tao-Yeuan Wang, Fuu-Jen Tsai, Hung-Hung Lin, Pei-Chen Wu, and Wayseen Wang
Taiwanese Journal of Obstetrics and Gynecology, 2010, Volume 49, Number 2, Page 206
[6]
T. Lazzarotto, B. Guerra, L. Gabrielli, M. Lanari, and M.P. Landini
Clinical Microbiology and Infection, 2011, Volume 17, Number 9, Page 1285
[7]
Mary A. Vogler, Harjot Singh, and Rodney Wright
Current HIV/AIDS Reports, 2011, Volume 8, Number 2, Page 122
[8]
Sócrates Bezerra de Matos, Roberto Meyer, and Fernanda Washington de Mendonça Lima
Journal of Medical Virology, 2011, Volume 83, Number 2, Page 298

Comments (0)

Please log in or register to comment.
Log in