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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


IMPACT FACTOR 2017: 1.558
5-year IMPACT FACTOR: 1.653

CiteScore 2017: 1.26

SCImago Journal Rank (SJR) 2017: 0.594
Source Normalized Impact per Paper (SNIP) 2017: 0.684

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1619-3997
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Volume 37, Issue 2

Issues

Group B Streptococcus colonization in pregnancy: prevalence and prevention strategies of neonatal sepsis

Alma-Verena Rausch
  • 1Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, and University of Bern, Switzerland
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/ Ariane Gross
  • 2Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, and University of Bern, Switzerland
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/ Sara Droz
  • 3Institute of Infectious Diseases, Inselspital, Bern University Hospital, and University of Bern, Switzerland
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/ Thomas Bodmer
  • 4Institute of Infectious Diseases, Inselspital, Bern University Hospital, and University of Bern, Switzerland
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/ Daniel V. Surbek
  • 5Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, and University of Bern, Switzerland
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Published Online: 2008-10-31 | DOI: https://doi.org/10.1515/JPM.2009.020

Abstract

Early onset neonatal sepsis due to Group B streptococci (GBS) is responsible for severe morbidity and mortality of newborns. While different preventive strategies to identify women at risk are being recommended, the optimal strategy depends on the incidence of GBS-sepsis and on the prevalence of anogenital GBS colonization. We therefore aimed to assess the Group B streptococci prevalence and its consequences on different prevention strategies.

We analyzed 1316 pregnant women between March 2005 and September 2006 at our institution. The prevalence of GBS colonization was determined by selective cultures of anogenital smears. The presence of risk factors was analyzed. In addition, the direct costs of screening and intrapartum antibiotic prophylaxis were estimated for different preventive strategies.

The prevalence of GBS colonization was 21%. Any maternal intrapartum risk factor was present in 37%. The direct costs of different prevention strategies have been estimated as follows: risk-based: 18,500 CHF/1000 live births, screening-based: 50,110 CHF/1000 live births, combined screening- and risk-based: 43,495/1000 live births.

Strategies to prevent GBS-sepsis in newborn are necessary. With our colonization prevalence of 21%, and the intrapartum risk profile of women, the screening-based approach seems to be superior as compared to a risk-based approach.

Keywords: Costs; GBS-sepsis; intrapartum antibiotics; prevalence; screening and risk factor based strategies

About the article

Corresponding author: Prof. Daniel Surbek, MD Department of Obstetrics and Gynecology University Hospital Bern Effingerstr. 102 3010 Bern/Switzerland Tel.: +41 31 632 11 03 Fax: +41 31 632 11 05


Received: 2008-05-27

Revised: 2008-07-24

Accepted: 2008-09-01

Published Online: 2008-10-31

Published Online: 2008-10-31

Published in Print: 2009-03-01


Citation Information: Journal of Perinatal Medicine, Volume 37, Issue 2, Pages 124–129, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2009.020.

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