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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland


IMPACT FACTOR increased in 2015: 1.798
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SCImago Journal Rank (SJR) 2014: 0.731
Source Normalized Impact per Paper (SNIP) 2014: 0.687
Impact per Publication (IPP) 2014: 1.483

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1619-3997
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Group B Streptococcus colonization in pregnancy: prevalence and prevention strategies of neonatal sepsis

Alma-Verena Rausch1 / Ariane Gross2 / Sara Droz3 / Thomas Bodmer4 / Daniel V. Surbek5

1Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, and University of Bern, Switzerland

2Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, and University of Bern, Switzerland

3Institute of Infectious Diseases, Inselspital, Bern University Hospital, and University of Bern, Switzerland

4Institute of Infectious Diseases, Inselspital, Bern University Hospital, and University of Bern, Switzerland

5Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, and University of Bern, Switzerland

Corresponding author: Prof. Daniel Surbek, MD Department of Obstetrics and Gynecology University Hospital Bern Effingerstr. 102 3010 Bern/Switzerland Tel.: +41 31 632 11 03 Fax: +41 31 632 11 05

Citation Information: Journal of Perinatal Medicine. Volume 37, Issue 2, Pages 124–129, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2009.020, October 2008

Publication History

Received:
2008-05-27
Revised:
2008-07-24
Accepted:
2008-09-01
Published Online:
2008-10-31

Abstract

Early onset neonatal sepsis due to Group B streptococci (GBS) is responsible for severe morbidity and mortality of newborns. While different preventive strategies to identify women at risk are being recommended, the optimal strategy depends on the incidence of GBS-sepsis and on the prevalence of anogenital GBS colonization. We therefore aimed to assess the Group B streptococci prevalence and its consequences on different prevention strategies.

We analyzed 1316 pregnant women between March 2005 and September 2006 at our institution. The prevalence of GBS colonization was determined by selective cultures of anogenital smears. The presence of risk factors was analyzed. In addition, the direct costs of screening and intrapartum antibiotic prophylaxis were estimated for different preventive strategies.

The prevalence of GBS colonization was 21%. Any maternal intrapartum risk factor was present in 37%. The direct costs of different prevention strategies have been estimated as follows: risk-based: 18,500 CHF/1000 live births, screening-based: 50,110 CHF/1000 live births, combined screening- and risk-based: 43,495/1000 live births.

Strategies to prevent GBS-sepsis in newborn are necessary. With our colonization prevalence of 21%, and the intrapartum risk profile of women, the screening-based approach seems to be superior as compared to a risk-based approach.

Keywords: Costs; GBS-sepsis; intrapartum antibiotics; prevalence; screening and risk factor based strategies

Citing Articles

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[1]
Joyce M. Koenig and William J. Keenan
Pediatric Clinics of North America, 2009, Volume 56, Number 3, Page 689
[2]
Mirjam Kunze, Anna Ziegler, Kirsten Fluegge, Roland Hentschel, Heinrich Proempeler, and Reinhard Berner
Journal of Perinatal Medicine, 2011, Volume 39, Number 4

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