Jump to ContentJump to Main Navigation
Show Summary Details

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

IMPACT FACTOR increased in 2015: 1.798
Rank 46 out of 120 in category Pediatrics in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.731
Source Normalized Impact per Paper (SNIP) 2014: 0.687
Impact per Publication (IPP) 2014: 1.483

See all formats and pricing


Select Volume and Issue


Preterm labor and bacterial vaginosis-associated bacteria among urban women

Deborah B. Nelson1 / Alexandra Hanlon2 / Sarmina Hassan3 / Johnson Britto4 / Osnat Geifman-Holtzman5 / Catherine Haggerty6 / David N. Fredricks7

1Department of Public Health, College of Health Professions, Temple University, USA and Department of Obstetrics/Gynecology, School of Medicine, Temple University, USA

2Department of Public Health, College of Health Professions, Temple University, USA

3Department of Obstetrics/Gynecology, School of Medicine, Temple University, USA

4Department of Public Health, College of Health Professions, Temple University, USA

5Department of Obstetrics/Gynecology, School of Medicine, Temple University, USA

6Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, USA

7Fred Hutchinson Cancer Research Center, University of Washington, USA

Corresponding author: Deborah B. Nelson, PhD Temple University 1301 Cecil B. Moore Ave Room 905 Philadelphia PA 19122 USA Tel.: +1-215-204-9659 Fax: +1-215-204-1854

Citation Information: Journal of Perinatal Medicine. Volume 37, Issue 2, Pages 130–134, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2009.026, November 2008

Publication History

Published Online:


Aims: Bacterial vaginosis (BV) affects millions of women, is extremely prevalent and is frequently chronic. We recognize numerous microbiologic variations among women with BV and this variability may explain the limited effectiveness of metronidazole in curing BV and/or reducing the risk of spontaneous preterm birth (SPTB) among BV-positive pregnant women. We assessed the independent role of seven common BV-associated bacteria on the risk of spontaneous preterm birth (SPTB) among urban pregnant women.

Methods: This prospective cohort study was conducted within an urban obstetrics practice at Temple University Hospital in Philadelphia, PA. Fifty pregnant women with documented singleton pregnancies between 25–36 weeks' gestation from February 2007 through June 2007 who presented to the Labor and Delivery Unit for evaluation of uterine contractions/preterm labor were enrolled.

Results: We found that high median levels of Gardnerella vaginalis and low median levels of Lactobacillus crispatus were significantly predictive of SPTB. Slightly higher levels of Megasphaera-like species were also found among the group of women experiencing a SPTB during the follow-up period.

Conclusions: Further identification of the individual attributable risk for separate BV-associated bacteria may be most useful in developing successful treatments to prevent SPTB among BV positive women.

Keywords: Bacterial vaginosis; Gardnerella vaginalis; Lactobacillus crispatus; spontaneous preterm birth

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

J. M. Fettweis, J. P. Brooks, M. G. Serrano, N. U. Sheth, P. H. Girerd, D. J. Edwards, J. F. Strauss, K. K. Jefferson, and G. A. Buck
Microbiology, 2014, Volume 160, Number Pt_10, Page 2272
Deborah B. Nelson, Alexandra Hanlon, Irving Nachamkin, Catherine Haggerty, Dimitrios S. Mastrogiannis, Congzhou Liu, and David N. Fredricks
Paediatric and Perinatal Epidemiology, 2014, Volume 28, Number 2, Page 88
Caroline Mitchell, Michelle L. Gottsch, Congzhou Liu, David N. Fredricks, and Deborah B. Nelson
American Journal of Obstetrics and Gynecology, 2013, Volume 208, Number 2, Page 132.e1
Rebecca M. Brotman
Journal of Clinical Investigation, 2011, Volume 121, Number 12, Page 4610
Jeanne M. Marrazzo, David H. Martin, D. Heather Watts, Joann Schulte, Jack D. Sobel, Sharon L. Hillier, Carolyn Deal, and David N. Fredricks
Sexually Transmitted Diseases, 2010, Volume 37, Number 12, Page 732

Comments (0)

Please log in or register to comment.