Jump to ContentJump to Main Navigation
Show Summary Details

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

IMPACT FACTOR increased in 2015: 1.798
Rank 46 out of 120 in category Pediatrics in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.731
Source Normalized Impact per Paper (SNIP) 2014: 0.687
Impact per Publication (IPP) 2014: 1.483

99,00 € / $149.00 / £75.00*

See all formats and pricing


Select Volume and Issue


Maternal visfatin concentration in normal pregnancy

Shali Mazaki-Tovi1, 2 / Roberto Romero1, 3 / Juan Pedro Kusanovic1, 2 / Edi Vaisbuch1, 2 / Offer Erez1, 2 / Nandor Gabor Than1 / Tinnakorn Chaiworapongsa1, 2 / Chia-Ling Nhan-Chang1, 2 / Percy Pacora1 / Francesca Gotsch1 / Lami Yeo1, 2 / Sun Kwon Kim1 / Samuel S. Edwin1 / Sonia S. Hassan1, 2 / Pooja Mittal1, 2

1Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, and Detroit, MI, USA

2Department of Obstetrics and Gynecology, Wayne State University/Hutzel Women's Hospital, Detroit, MI, USA

3Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA

Corresponding author: Roberto Romero, MD Perinatology Research Branch Intramural Division, NICHD/NIH/DHHS Hutzel Women's Hospital-Box No. 4 3990 John R, Detroit MI 48201, USA Tel.: +1 (313) 993-2700 Fax: +1 (313) 993-2694

Citation Information: Journal of Perinatal Medicine. Volume 37, Issue 3, Pages 206–217, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/JPM.2009.054, December 2008

Publication History

Published Online:


Objective: Adipose tissue has now emerged as a powerful endocrine organ via the production of adipokines. Visfatin, a novel adipokine with diabetogenic and immuno-modulatory properties has been implicated in the pathophysiology of insulin resistance in patients with obesity and Type-2 diabetes mellitus. The aim of this study was to determine whether there are changes in the maternal plasma concentration of visfatin with advancing gestation and as a function of maternal weight.

Study design: In this cross-sectional study, maternal plasma concentrations of visfatin were determined in normal weight and overweight/obese pregnant women in the following gestational age groups: 1) 11–14 weeks (n=52); 2) 19–26 weeks (n=68); 3) 27–34 weeks (n=93); and 4) >37 weeks (n=60). Visfatin concentrations were determined by ELISA. Non parametric statistics were used for analysis.

Results: 1) The median maternal plasma visfatin concentration was higher in pregnant women between 19–26 weeks of gestation than that of those between 11–14 weeks of gestation (P<0.01) and those between 27–34 weeks of gestation (P<0.01); 2) among normal weight pregnant women, the median plasma visfatin concentrations of women between 19–26 weeks of gestation was higher than that of those between 11–14 weeks (P<0.01) and those between 27–34 weeks (P<0.01); and 3) among overweight/obese patients, the median maternal visfatin concentration was similar between the different gestational age groups.

Conclusion: The median maternal plasma concentration of visfatin peaks between 19–26 and has a nadir between 27–34 weeks of gestation. Normal and overweight/obese pregnant women differed in the pattern of changes in circulating visfatin concentrations as a function of gestational age.

Keywords: Adipokines; obesity; overweight; pregnancy; visfatin

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Seham AlSaif, Sadaf Mumtaz, and Susan Wray
Life Sciences, 2015, Volume 125, Page 2
Sadaf Mumtaz, Seham AlSaif, Susan Wray, and Karen Noble
Life Sciences, 2015, Volume 125, Page 57
Alberto Benito-Martin, Alvaro C. Ucero, María Concepción Izquierdo, Beatriz Santamaria, Belén Picatoste, Susana Carrasco, Oscar Lorenzo, Marta Ruiz-Ortega, Jesus Egido, and Alberto Ortiz
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014, Volume 1842, Number 2, Page 293
Amani F. H. Noureldeen, Safaa Y. Qusti, Madeha N. Al-seeni, and Maram H. Bagais
Indian Journal of Clinical Biochemistry, 2014, Volume 29, Number 4, Page 462
Saeid Golbidi and Ismail Laher
Journal of Nutrition and Metabolism, 2013, Volume 2013, Page 1
Shali Mazaki-Tovi, Michal Kasher-Meron, Rina Hemi, Jigal Haas, Itai Gat, Daniel Lantsberg, Israel Hendler, and Hannah Kanety
American Journal of Obstetrics and Gynecology, 2012, Volume 207, Number 5, Page 412.e1
A F A Ferreira, J C Rezende, R de Cassia C. Oliveira, R Akolekar, and K H Nicolaides
Journal of Human Hypertension, 2013, Volume 27, Number 4, Page 261
Nikolaos Vrachnis, Panagiotis Belitsos, Stavros Sifakis, Konstantinos Dafopoulos, Charalambos Siristatidis, Kalliopi I. Pappa, and Zoe Iliodromiti
International Journal of Endocrinology, 2012, Volume 2012, Page 1
Konstanze Miehle, Holger Stepan, and Mathias Fasshauer
Clinical Endocrinology, 2012, Volume 76, Number 1, Page 2
Shali Mazaki-Tovi, Hannah Kanety, Clara Pariente, Rina Hemi, Eleanor Yissachar, Eyal Schiff, Ohad Cohen, and Eyal Sivan
Gynecological Endocrinology, 2011, Volume 27, Number 9, Page 725
Shali Mazaki-Tovi, Roberto Romero, Edi Vaisbuch, Tinnakorn Chaiworapongsa, Offer Erez, Pooja Mittal, Sun Kwon Kim, Francesca Gotsch, Ronald Lamont, Giovanna Ogge, Percy Pacora, Luis Goncalves, Chong Jai Kim, Ricardo Gomez, Jimmy Espinoza, Sonia S. Hassan, and Juan Pedro Kusanovic
Journal of Perinatal Medicine, 2010, Volume 38, Number 1
Shali Mazaki-Tovi, Edi Vaisbuch, Roberto Romero, Juan Pedro Kusanovic, Tinnakorn Chaiworapongsa, Sun Kwon Kim, Chia-Ling Nhan-Chang, Ricardo Gomez, Bo H. Yoon, Lami Yeo, Pooja Mittal, Giovanna Ogge, Juan M. Gonzalez, and Sonia S. Hassan
American Journal of Reproductive Immunology, 2010, Volume 63, Number 3, Page 252

Comments (0)

Please log in or register to comment.