Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


IMPACT FACTOR 2018: 1.361
5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

SCImago Journal Rank (SJR) 2018: 0.522
Source Normalized Impact per Paper (SNIP) 2018: 0.602

Online
ISSN
1619-3997
See all formats and pricing
More options …
Volume 37, Issue 5

Issues

Effect of exogenous surfactant therapy on levels of pulmonary surfactant proteins A and D in preterm infants with respiratory distress syndrome

Young Min Bae / Chong-Woo Bae / Myung Ho Oh
  • Department of Pediatrics, College of Medicine, Soonchunhyang University, Cheonan 330-721, Korea
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sang Han Lee
  • Department of Biochemistry, College of Medicine, Soonchunhyung University, Cheonan 330-721, Korea
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Kee Min Woo
  • Department of Biochemistry, College of Medicine, Soonchunhyung University, Cheonan 330-721, Korea
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Keum Bun Jung
  • Department of Biochemistry, College of Medicine, Soonchunhyung University, Cheonan 330-721, Korea
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-06-03 | DOI: https://doi.org/10.1515/JPM.2009.100

Abstract

Objectives: To examine whether exogenous pulmonary surfactants (exPS) substitute for or merely supplement endogenous pulmonary surfactants (enPS) by looking at sequential changes in the surfactant proteins (SP) SP-A and SP-D in alveolar pools.

Methods: Fourteen preterm infants with RDS treated with an artificial surfactant were compared to five normal-term infants without RDS who were treated with artificial ventilation at birth.

Results: Immediately after birth, SP-A and SP-D were essentially absent in the alveolar pools of the RDS group, but were present at normal levels in the controls. Treatment with exPS apparently stimulated enPS production.

Conclusions: In infants who responded well to exPS therapy, the SP concentration reached essentially normal levels within 48–72 h after birth.

Keywords: Endogenous pulmonary surfactants; exogenous pulmonary surfactants; surfactant proteins

About the article

Corresponding author: Chong-Woo Bae, MD, PhD Department of Pediatrics College of Medicine Kyunghee University East-West Neo Medical Center 149 Sangil-dong Kangdong-ku Seoul 134-727 Korea Tel.: +82-2-440-6130 Fax: +82-2-440-7175


Received: 2008-12-11

Revised: 2009-03-19

Accepted: 2009-04-03

Published Online: 2009-06-03

Published Online: 2009-06-03

Published in Print: 2009-09-01


Citation Information: Journal of Perinatal Medicine, Volume 37, Issue 5, Pages 561–564, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2009.100.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Amélie Collins, Jörn-Hendrik Weitkamp, and James L Wynn
Archives of Disease in Childhood - Fetal and Neonatal Edition, 2018, Volume 103, Number 4, Page F391
[2]
Grith L. Sorensen
Frontiers in Medicine, 2018, Volume 5
[3]
Grith Lykke Sorensen, Marianne Dahl, Qihua Tan, Christian Bendixen, Uffe Holmskov, and Steffen Husby
The Journal of Pediatrics, 2014, Volume 165, Number 4, Page 683
[4]
Iliana Bersani, Steffen Kunzmann, and Christian P Speer
Expert Review of Anti-infective Therapy, 2013, Volume 11, Number 1, Page 99
[5]
Iliana Bersani, Christian P Speer, and Steffen Kunzmann
Expert Review of Anti-infective Therapy, 2012, Volume 10, Number 5, Page 573

Comments (0)

Please log in or register to comment.
Log in