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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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Online
ISSN
1619-3997
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In This Section
Volume 37, Issue 6 (Nov 2009)

Issues

Nuchal translucency and lymphatic system maldevelopment

Carlo Bellini
  • Department of Pediatrics (DIPE), University of Genoa, Gaslini Institute, largo G. Gaslini, 5, 16147 Genova, Italy
  • Both authors contributed equally to the paper.
/ Mariangela Rutigliani
  • Department of Pathology (DICMI), S. Martino Hospital, University of Genoa, viale Benedetto XV, 16145 Genova, Italy
  • Both authors contributed equally to the paper.
/ Francesco M. Boccardo
  • Department of Surgery, Lymphatic Surgery and Microsurgery Unit, S. Martino Hospital, University of Genoa, viale Benedetto XV, 16145 Genova, Italy
/ Eugenio Bonioli
  • Department of Pediatrics (DIPE), University of Genoa, Gaslini Institute, largo G. Gaslini, 5, 16147 Genova, Italy
/ Corradino Campisi
  • Department of Surgery, Lymphatic Surgery and Microsurgery Unit, S. Martino Hospital, University of Genoa, viale Benedetto XV, 16145 Genova, Italy
/ Federica Grillo
  • Department of Pathology (DICMI), S. Martino Hospital, University of Genoa, viale Benedetto XV, 16145 Genova, Italy
/ Tommaso Bellini
  • Department of Pediatrics (DIPE), University of Genoa, Gaslini Institute, largo G. Gaslini, 5, 16147 Genova, Italy
/ Mario Valenzano
  • Department of Obstetrics and Gynecology, University of Genoa, Largo R. Benzi 10, 16132 Genova, Italy
/ Ezio Fulcheri
  • Department of Pathology (DICMI), S. Martino Hospital, University of Genoa, viale Benedetto XV, 16145 Genova, Italy
Published Online: 2009-07-10 | DOI: https://doi.org/10.1515/JPM.2009.107

Abstract

We describe the histological examination of 18 aborted fetuses that had increased nuchal translucency (NT) between 11+0 and 13+6 weeks' gestation. The aim of this study was to assess the corresponding NT anatomic features by immunohistochemical (IHC) investigation. A morphological study was performed using lymphatic and blood endothelial specific markers, as well as smooth muscle actin (SMA). We found that all 18 cases were D2-40 positive, CD31 positive, and CD34 negative, suggesting the presence of nuchal lymph vessel ectasia. We found that 12/18 cases were SMA staining positive and 6/18 cases were SMA negative, suggesting that 6/18 cases had nuchal cystic lymphangiectasia, whereas 12/18 had cystic hygromas. The present data seem to confirm the reasonable hypothesis that lymphangiogenesis plays a relevant role in nuchal edema, increased NT, and that increased NT is the result of a lymphatic malformation or a delayed development of the lymphatic system.

Keywords: Cystic hygroma; edema with nuchal cystic lymphangiectasia; nuchal translucency (NT)

About the article

Corresponding author: Carlo Bellini, MD, PhD Dipartimento di Pediatria Università di Genova Istituto G. Gaslini, Largo G. Gaslini 5 16147 Genova Italy Tel.: +39 10 5636762 Fax: +39 10 3770675


Received: 2009-02-17

Revised: 2009-04-30

Accepted: 2009-05-04

Published Online: 2009-07-10

Published Online: 2009-07-10

Published in Print: 2009-11-01



Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2009.107. Export Citation

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