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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica

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Volume 37, Issue 6


The clinical outcomes of late preterm infants: a multi-center survey of Zhejiang, China

Xiaolu Ma / Chunxiang Huang / Shouzeng Lou / Qin Lv / Weidong Su / Jiarong Tan / Youcheng Wang / Xinxin Wang / Mingyuan Wu / Ting Xu
  • Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
  • Jinhua Central Hospital, Jinhua, Zhejing, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Manli Zhuang
  • Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
  • Zhoushan Women and Children's Hospital, Zhoushan, Zhejiang, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Lizhong Du / the Provincial Collaborative Study Group for Late-preterm Infants
Published Online: 2009-07-10 | DOI: https://doi.org/10.1515/JPM.2009.130


Objective: To explore birth rate, delivery mode, medical problems, requirement of respiratory support, and acute outcomes of late preterm infants in Zhejiang province in eastern China.

Methods: Eleven tertiary hospitals were recruited. Clinical data of every nursery admission from January to December 2007 were collected and analyzed.

Results: During the study period, 44,362 infants were born with an overall preterm birth rate of 8.9%, and late preterm birth rate of 6.2%. Late preterm infants had higher cesarean section rate than the whole population (64.9% vs. 58.2%). One-fifth of the nursery admissions were late preterm infants, of whom, 63.8% were delivered by cesarean section. Respiratory distress (42.1%) was the most common medical problem of late preterm infants. Hyperbilirubinemia (17.6%), hypoglycemia (8.7%) and sepsis (5.9%) were also common. The first three primary diagnoses of respiratory distress included pneumonia (39.5%), transient tachypnea of newborn (TTN) (22.5%) and respiratory distress syndrome (RDS) (19.0%). Compared with term infants, late preterm infants with respiratory distress needed more respiratory support with nasal continuous positive airway pressure (nCPAP) (21.4% vs. 11.6%) or with a mechanical ventilator (15.4% vs. 11.0%), and also had higher in-hospital mortality (0.8% vs. 0.4%).

Conclusions: Late preterm infants are associated with very high cesarean section rate and have more medical problems and poorer short-term outcomes than term infants in China.

Keywords: Cesarean section; late preterm; outcome; respiratory distress syndrome; transient tachypnea

About the article

Corresponding author: Lizhong Du, PhD Children's Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang China

Received: 2009-02-11

Revised: 2009-04-14

Accepted: 2009-05-28

Published Online: 2009-07-10

Published in Print: 2009-11-01

Citation Information: Journal of Perinatal Medicine, Volume 37, Issue 6, Pages 695–699, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/JPM.2009.130.

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