Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Reiss, Irwin / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year


IMPACT FACTOR 2016: 1.577
5-year IMPACT FACTOR: 1.705

CiteScore 2016: 1.49

SCImago Journal Rank (SJR) 2016: 0.602
Source Normalized Impact per Paper (SNIP) 2016: 0.832

Online
ISSN
1619-3997
See all formats and pricing
More options …
Volume 38, Issue 1 (Jan 2010)

Issues

Low circulating maternal adiponectin in patients with pyelonephritis: adiponectin at the crossroads of pregnancy and infection

Shali Mazaki-Tovi
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Department of Obstetrics and Gynecology, Wayne State University/Hutzel Women's Hospital, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Roberto Romero
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Department of Obstetrics and Gynecology, Wayne State University/Hutzel Women's Hospital, Detroit, MI, USA
  • Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Edi Vaisbuch
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Department of Obstetrics and Gynecology, Wayne State University/Hutzel Women's Hospital, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Tinnakorn Chaiworapongsa
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Department of Obstetrics and Gynecology, Wayne State University/Hutzel Women's Hospital, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Offer Erez
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Department of Obstetrics and Gynecology, Wayne State University/Hutzel Women's Hospital, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Pooja Mittal
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Department of Obstetrics and Gynecology, Wayne State University/Hutzel Women's Hospital, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sun Kwon Kim
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Francesca Gotsch
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ronald Lamont
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Department of Obstetrics and Gynecology, Wayne State University/Hutzel Women's Hospital, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Giovanna Ogge
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Percy Pacora
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Luis Goncalves
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Chong Jai Kim
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ricardo Gomez
  • Center for Perinatal Diagnosis and Research (CEDIP), Hospital Sotero del Rio, P. Universidad Catolica de Chile, Puente Alto, Chile
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jimmy Espinoza
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sonia S. Hassan
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Department of Obstetrics and Gynecology, Wayne State University/Hutzel Women's Hospital, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Juan Pedro Kusanovic
  • Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, Detroit, MI, USA
  • Department of Obstetrics and Gynecology, Wayne State University/Hutzel Women's Hospital, Detroit, MI, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-08-04 | DOI: https://doi.org/10.1515/jpm.2009.134

Abstract

Objective: An emerging theme in modern biology is that adipose tissue can respond to metabolic stress, and to inflammatory stimuli, by regulating the secretion of a complex network of soluble mediators, termed adipokines. Adiponectin, the most prevalent circulating adipokine in human, has profound insulin-sensitizing and anti-inflammatory properties. Indeed, the notion that adiponectin plays an important role in the interactions between the metabolic and the immune systems has been strongly suggested. Thus, the aim of this study was to determine if pyelonephritis during pregnancy is associated with changes in maternal serum adiponectin concentrations.

Study design: This cross-sectional study included women in the following groups: 1) normal pregnant women (n=200); and 2) pregnant women with pyelonephritis (n=50). Maternal plasma adiponectin concentrations were determined by ELISA. Non-parametric statistics were used for analyses.

Results: 1) The median maternal plasma adiponectin concentration was lower in patients with pyelonephritis than in those with a normal pregnancy (P<0.001); 2) among pregnant women with a normal weight, patients with pyelonephritis had a lower median plasma adiponectin concentration than those with a normal pregnancy (P<0.001); 3) similarly, among overweight/obese patients, those with pyelonephritis had a lower median plasma adiponectin concentration than those with a normal pregnancy (P<0.001); and 4) the presence of pyelonephritis was independently associated with maternal plasma adiponectin concentrations after adjustment for maternal age, smoking, gestational age at sampling, and pregestational body mass index (BMI).

Conclusion: 1) The findings that acute pyelonephritis in pregnancy is characterized by low maternal plasma concentrations of adiponectin in both lean and overweight/obese patients are novel and concur with the antiinflammatory properties of adiponectin; and 2) the results of this study support the notion that adiponectin may play a role in the intricate interface between inflammation and metabolism during pregnancy.

Keywords: Acute bacterial infection; adipokines; adiponectin; infection; inflammation; pregnancy; pyelonephritis

About the article

Corresponding author: Roberto Romero, MD Perinatology Research Branch Intramural Division NICHD/NIH/DHHS Hutzel Women's Hospital-Box No. 4 3990 John R Detroit MI 48201 USA Tel.: +1(313) 993-2700 Fax: +1(313) 993-2694


Received: 2009-05-18

Accepted: 2009-06-23

Published Online: 2009-08-04

Published Online: 2009-08-04

Published in Print: 2010-01-01


Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm.2009.134.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Nardhy Gomez-Lopez, Roberto Romero, Marcia Arenas-Hernandez, Bogdan Panaitescu, Valeria Garcia-Flores, Tara N. Mial, Aashna Sahi, and Sonia S. Hassan
The Journal of Maternal-Fetal & Neonatal Medicine, 2017, Page 1
[2]
Edi Vaisbuch, Roberto Romero, Shali Mazaki-Tovi, Juan Pedro Kusanovic, Tinnakorn Chaiworapongsa, Zhong Dong, Sun Kwon Kim, Giovanna Ogge, Maria Teresa Gervasi, and Sonia S. Hassan
Journal of Perinatal Medicine, 2010, Volume 38, Number 4

Comments (0)

Please log in or register to comment.
Log in