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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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In This Section
Volume 38, Issue 2 (Mar 2010)


Intracerebral transplantation of mesenchymal stem cells derived from human umbilical cord blood alleviates hypoxic ischemic brain injury in rat neonates

Guizhi Xia
  • Department of Pediatrics, Xijing Hospital, The Fourth Military Medical University, Xi'an, China
/ Xinru Hong
  • The Institute of Child Health of PLA, Fuzhou General Hospital, Fuzhou, China
/ Xinmin Chen
  • The Institute of Child Health of PLA, Fuzhou General Hospital, Fuzhou, China
/ Fenghua Lan
  • Center for Molecular Medicine, Fuzhou General Hospital, Fuzhou, China
/ Guocheng Zhang
  • Department of Pediatrics, Xijing Hospital, The Fourth Military Medical University, Xi'an, China
/ Lianming Liao
  • Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Published Online: 2010-02-02 | DOI: https://doi.org/10.1515/jpm.2010.021


Aims: Fetal hypoxic-ischemic brain injury (HIBI) is a severe condition for which no effective therapy exists. In this study mesenchymal stem cells (MSCs) from human umbilical cord blood (UCB) of full-term newborns were isolated and intracerebrally transplanted into rat neonates after HIBI induction. Nerve function was assessed by the modified neurological severity scores (mNSS) to establish if MSCs could alleviate nerve injury.

Results: Immunostaining showed the transplanted MSCs migrated to the hippocampus. Rats receiving MSCs treatment showed significant improvement in the mNSS when compared with controls. Also, histochemical study showed alleviation of brain tissue injury after MSCs treatment. Differentiation of MSCs to astrocytes, but not neurons, was observed.

Conclusions: The results indicate a beneficial effect of intracerebral transplantation of MSCs on the functional recovery of rat neonates with HIBI.

Keywords: Cord blood; fetal hypoxic-ischemic brain injury; mesenchymal stem cells

About the article

Corresponding authors: Guocheng Zhang Department of Pediatrics Xijing Hospital The Fourth Military Medical University Xi'an 710032 China Tel.: +86-29-8477-5395 (Office) Fax: +86-29-8477-3306 Xinru Hong The Institute of Child Health of PLA Fuzhou General Hospital Fuzhou 350025 China Tel.: +86-591-2285-9200 (Office)/+86-591-8379-3257 (Home) Fax: +86-591-3812-1219

Received: 2009-03-21

Revised: 2009-08-05

Accepted: 2009-11-13

Published Online: 2010-02-02

Published Online: 2010-02-02

Published in Print: 2010-03-01

Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm.2010.021. Export Citation

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