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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year

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Rank 46 out of 120 in category Pediatrics in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.731
Source Normalized Impact per Paper (SNIP) 2014: 0.687
Impact per Publication (IPP) 2014: 1.483

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Volume 38, Issue 3 (May 2010)


The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery

Sharon M. Cooley
  • Rotunda Hospital, Parnell Street, Dublin 1, Ireland
/ Jennifer C. Donnelly
  • Rotunda Hospital, Parnell Street, Dublin 1, Ireland
/ Claire Collins
  • Rotunda Hospital, Parnell Street, Dublin 1, Ireland
/ Michael P. Geary
  • Rotunda Hospital, Parnell Street, Dublin 1, Ireland
/ Charles H. Rodeck
  • University College London, Gower Street, London, WC1E 6BT, England
/ Peter C. Hindmarsh
  • University College London, Gower Street, London, WC1E 6BT, England
Published Online: 2010-02-02 | DOI: https://doi.org/10.1515/jpm.2010.019


Aims: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery.

Methods: Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery.

Results: There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02).

Conclusion: Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.

Keywords: Insulin-like growth factor; insulin-like growth factor binding protein; preterm delivery

About the article

Corresponding author: Dr. Sharon M. Cooley, MRCOG c/o Rotunda Hospital Parnell Street Dublin 1 Ireland Tel.: +353 1 8730700 Fax: +353 1 8726523

Received: 2009-01-23

Revised: 2009-10-16

Accepted: 2009-10-29

Published Online: 2010-02-02

Published Online: 2010-02-02

Published in Print: 2010-05-01

Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm.2010.019. Export Citation

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