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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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1619-3997
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Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controlled trial of selenium supplementation

Fatemeh Tara
  • Gynecology Hospital, Faculty of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
/ Margaret P. Rayman
  • Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK
/ Hassan Boskabadi
  • Neonatal Research Center, Faculty of Medicine, MUMS, Mashhad, Iran
/ Majid Ghayour-Mobarhan
  • Cardiovascular Research Center, Avicenna Research Institute, MUMS, Mashhad, Iran
  • Department of Biochemistry and Nutrition, Faculty of Medicine, MUMS, Mashhad, Iran
/ Amirhossein Sahebkar
  • Cardiovascular Research Center, Avicenna Research Institute, MUMS, Mashhad, Iran
/ Daryoush H. Alamdari
  • Department of Biochemistry and Nutrition, Faculty of Medicine, MUMS, Mashhad, Iran
/ Behjat S. Razavi
  • Cardiovascular Research Center, Avicenna Research Institute, MUMS, Mashhad, Iran
/ Shima Tavallaie
  • Cardiovascular Research Center, Avicenna Research Institute, MUMS, Mashhad, Iran
/ Mohsen Azimi-Nezhad
  • Cardiovascular Research Center, Avicenna Research Institute, MUMS, Mashhad, Iran
/ Mohammad T. Shakeri
  • Department of Statistics, Faculty of Medicine, MUMS, Mashhad, Iran
/ Mohammadreza Oladi
  • Cardiovascular Research Center, Avicenna Research Institute, MUMS, Mashhad, Iran
/ Omid Yazarlu
  • Gynecology Hospital, Faculty of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
/ Shaida Ouladan
  • Gynecology Hospital, Faculty of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
/ Maryam Teimoori Sangani
  • Gynecology Hospital, Faculty of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
/ Fatemeh Rezagholizadeh Omran
  • Gynecology Hospital, Faculty of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
/ Gordon Ferns
  • Institute for Science and Technology in Medicine, University of Keele, Guy Hilton Research Centre, Thornburrow Drive, Stoke on Trent, Staffordshire ST4 7QB, UK
Published Online: 2010-07-14 | DOI: https://doi.org/10.1515/jpm.2010.068

Abstract

Objective: We assessed the impact of selenium, a trace element with antioxidant properties on a simple measure of oxidative stress in pregnant women.

Study design: A novel assay of prooxidant-antioxidant balance (PAB) was applied in a double-blind, placebo-controlled study of selenium supplementation in pregnancy. We measured the prooxidant burden and the antioxidant capacity simultaneously in one assay, thereby calculating a redox index. A total of 166 primigravid pregnant women in the first trimester of pregnancy, were randomized to receive 100 μg of selenium (n=83) or placebo (n=83) per day until delivery. PAB values and serum selenium concentrations were measured at baseline and at the end of study.

Results: Pretreatment demographic data and biochemical indices including serum selenium concentrations did not differ significantly between the groups. The drop-out rates for the groups were 22/83 and 19/83 for the selenium and placebo groups, respectively. Supplementation with selenium was associated with a significant increase in mean serum selenium concentration (P<0.001) but without significant change in mean PAB value. In contrast, mean serum selenium concentration remained unchanged and mean PAB values increased significantly (P<0.05 in the control group).

Conclusion: Our findings suggest that selenium supplementation may reduce oxidative stress associated with pregnancy.

Keywords: Controlled clinical trial; oxidative stress; pregnancy; selenium

Corresponding author: Dr. Majid Ghayour-Mobarhan Department of Biochemistry and Nutrition Faculty of Medicine Mashhad University of Medical Science (MUMS) Mashhad Iran Tel.: +98-511-8828573 Fax: +98-511-8828574


Received: 2009-09-18

Revised: 2010-02-08

Accepted: 2010-02-09

Published Online: 2010-07-14

Published Online: 2010-07-14

Published in Print: 2010-09-01


Citation Information: Journal of Perinatal Medicine. Volume 38, Issue 5, Pages 473–478, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm.2010.068, July 2010

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