Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica

IMPACT FACTOR 2017: 1.558
5-year IMPACT FACTOR: 1.653

CiteScore 2017: 1.26

SCImago Journal Rank (SJR) 2017: 0.594
Source Normalized Impact per Paper (SNIP) 2017: 0.684

See all formats and pricing
More options …
Volume 38, Issue 5


Surfactant administration for neonatal respiratory distress does not improve lung interstitial fluid clearance: echographic and experimental evidence

Luigi Cattarossi
  • Departments of Paediatrics and Emergency Medicine, San Antonio Abate Hospital, Tolmezzo, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Roberto Copetti
  • Departments of Paediatrics and Emergency Medicine, San Antonio Abate Hospital, Tolmezzo, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Besa Poskurica / Giuseppe Miserocchi
Published Online: 2010-07-14 | DOI: https://doi.org/10.1515/jpm.2010.096


Objective: Recent ultrasonographic studies suggest that the administration of surfactant to preterm infants with respiratory distress syndrome (RDS) does not affect lung water clearance. The purpose of the study was also to look at clearance of lung water in preterm rabbits receiving surfactant.

Methods: Lung ultrasound was performed in 73 neonates at different gestational ages (range 23–34 weeks) with radiological and clinical signs of RDS, before and after surfactant administration. In premature rabbits (28–29 days’ gestational age), either receiving or not receiving surfactant, we followed the time course of lung water balance considering the wet weight/dry weight ratio, the morphology and compliance of alveoli and pulmonary interstitial pressure.

Results: In all RDS infants lung ultrasound images consistently showed a generalized increase in extravascular lung fluid which remained unchanged after surfactant administration and did not affect the rate of fluid clearance. Surfactant administration in premature rabbits did not improve the time course of lung fluid clearance.

Conclusions: Data from ultrasound in preterm babies are confirmed by animal experiments.

Keywords: Alveolar compliance; lung ultrasound; neonate; overdistension; pulmonary interstitial pressure; respiratory distress syndrome

About the article

Corresponding author: Luigi Cattarossi, MD San Antonio Abate Hospital Tolmezzo Via Carducci 4 33100 Udine Italy

Received: 2009-12-28

Revised: 2010-05-03

Accepted: 2010-05-11

Published Online: 2010-07-14

Published Online: 2010-07-14

Published in Print: 2010-09-01

Citation Information: Journal of Perinatal Medicine, Volume 38, Issue 5, Pages 557–563, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm.2010.096.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Douglas A Blank, C Omar Farouk Kamlin, Sheryle R Rogerson, Lisa M Fox, Laila Lorenz, Stefan Charles Kane, Graeme R Polglase, Stuart B Hooper, and Peter G Davis
Archives of Disease in Childhood - Fetal and Neonatal Edition, 2018, Volume 103, Number 2, Page F157
Francesco Raimondi, Nadya Yousef, Fiorella Migliaro, Letizia Capasso, and Daniele De Luca
Pediatric Research, 2018
Alessandro Perri, Riccardo Riccardi, Rossella Iannotta, Domenico V. Di Molfetta, Roberta Arena, Giovanni Vento, and Enrico Zecca
Pediatric Pulmonology, 2018
Noah H. Hillman, Ilias Nitsos, Clare Berry, J. Jane Pillow, Suhas G. Kallapur, and Alan H. Jobe
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2011, Volume 301, Number 5, Page L712
Chung-Ming Chen, Hsiu-Chu Chou, Willie Lin, and Chris Tseng
Stem Cell Research & Therapy, 2017, Volume 8, Number 1
Douglas A. Blank, Sheryle R. Rogerson, C. Omar F. Kamlin, Lisa M. Fox, Laila Lorenz, Stefan C. Kane, Graeme R. Polglase, Stuart B. Hooper, and Peter G. Davis
Resuscitation, 2017, Volume 114, Page 59
Douglas A Blank, Stuart B Hooper, Corinna Binder-Heschl, Martin Kluckow, Andrew W Gill, Domenic A LaRosa, Ishmael M Inocencio, Alison Moxham, Karyn Rodgers, Valerie A Zahra, Peter G Davis, and Graeme R Polglase
Journal of Paediatrics and Child Health, 2016, Volume 52, Number 6, Page 643
N. Yousef
Archives de Pédiatrie, 2016, Volume 23, Number 3, Page 317
Jing Liu, Fang Liu, Ying Liu, Hua-Wei Wang, and Zhi-Chun Feng
Chest, 2014, Volume 146, Number 2, Page 383
Luigi Cattarossi, Roberto Copetti, and Besa Poskurica
Chest, 2011, Volume 139, Number 3, Page 730
Luigi Cattarossi
Early Human Development, 2013, Volume 89, Page S17
Brian D. Coley
Radiologic Clinics of North America, 2011, Volume 49, Number 5, Page 825

Comments (0)

Please log in or register to comment.
Log in