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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto

9 Issues per year


IMPACT FACTOR 2017: 1.558
5-year IMPACT FACTOR: 1.653

CiteScore 2017: 1.26

SCImago Journal Rank (SJR) 2017: 0.594
Source Normalized Impact per Paper (SNIP) 2017: 0.684

Online
ISSN
1619-3997
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Volume 38, Issue 5

Issues

Surfactant administration for neonatal respiratory distress does not improve lung interstitial fluid clearance: echographic and experimental evidence

Luigi Cattarossi
  • Departments of Paediatrics and Emergency Medicine, San Antonio Abate Hospital, Tolmezzo, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Roberto Copetti
  • Departments of Paediatrics and Emergency Medicine, San Antonio Abate Hospital, Tolmezzo, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Besa Poskurica / Giuseppe Miserocchi
Published Online: 2010-07-14 | DOI: https://doi.org/10.1515/jpm.2010.096

Abstract

Objective: Recent ultrasonographic studies suggest that the administration of surfactant to preterm infants with respiratory distress syndrome (RDS) does not affect lung water clearance. The purpose of the study was also to look at clearance of lung water in preterm rabbits receiving surfactant.

Methods: Lung ultrasound was performed in 73 neonates at different gestational ages (range 23–34 weeks) with radiological and clinical signs of RDS, before and after surfactant administration. In premature rabbits (28–29 days’ gestational age), either receiving or not receiving surfactant, we followed the time course of lung water balance considering the wet weight/dry weight ratio, the morphology and compliance of alveoli and pulmonary interstitial pressure.

Results: In all RDS infants lung ultrasound images consistently showed a generalized increase in extravascular lung fluid which remained unchanged after surfactant administration and did not affect the rate of fluid clearance. Surfactant administration in premature rabbits did not improve the time course of lung fluid clearance.

Conclusions: Data from ultrasound in preterm babies are confirmed by animal experiments.

Keywords: Alveolar compliance; lung ultrasound; neonate; overdistension; pulmonary interstitial pressure; respiratory distress syndrome

About the article

Corresponding author: Luigi Cattarossi, MD San Antonio Abate Hospital Tolmezzo Via Carducci 4 33100 Udine Italy


Received: 2009-12-28

Revised: 2010-05-03

Accepted: 2010-05-11

Published Online: 2010-07-14

Published Online: 2010-07-14

Published in Print: 2010-09-01


Citation Information: Journal of Perinatal Medicine, Volume 38, Issue 5, Pages 557–563, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm.2010.096.

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