Jump to ContentJump to Main Navigation
Show Summary Details
In This Section

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year


IMPACT FACTOR 2016: 1.577
5-year IMPACT FACTOR: 1.705

CiteScore 2016: 1.49

SCImago Journal Rank (SJR) 2015: 0.829
Source Normalized Impact per Paper (SNIP) 2015: 0.808

Online
ISSN
1619-3997
See all formats and pricing
In This Section
Volume 38, Issue 6 (Nov 2010)

Issues

The expression pattern of two novel cytokines (IL-24 and IL-29) in human fetal membranes

Judith Nace
  • The Perinatal Research Center, Centennial Women's Hospital, Nashville, TN, USA
  • Women's Hospital, University of Heidelberg, Heidelberg, Germany
/ Stephen J. Fortunato
  • The Perinatal Research Center, Centennial Women's Hospital, Nashville, TN, USA
/ Holger Maul
  • Women's Hospital, University of Heidelberg, Heidelberg, Germany
/ Ramkumar Menon
  • The Perinatal Research Center, Centennial Women's Hospital, Nashville, TN, USA
  • Department of Epidemiology and Obstetrics and Gynaecology, Emory University, Atlanta, GA, USA
Published Online: 2010-08-13 | DOI: https://doi.org/10.1515/jpm.2010.093

Abstract

Objective: Interleukin (IL)-24 and -29 are novel cytokines, produced by immune cells in response to microbial antigens. The functions of these cytokines in the reproductive system are unknown. We examined the expression pattern of IL-24 and IL-29 in human fetal membranes from preterm and term births and in in vitro in response to microbial antigens.

Methods: Fetal membranes collected from cesarean sections at term (normal, not in labor) were placed in culture for 48 h. These membranes were then stimulated with bacterial lipopolysaccharide (LPS) or viral antigen poly-inosinic and cytidylic acid (polyIC) for an additional 24 h. Amniotic fluids (AF) and fetal membranes were also collected from preterm and term deliveries. IL-24 and IL-29 expressions were studied by RT-PCR. ELISA documented culture media and AF cytokine concentrations.

Results: IL-24 and IL-29 expressions were seen in cultured fetal membranes regardless of stimulation. Expressions were also found in preterm and term labor membranes, but not in non-labor tissues at term. IL-24 concentrations were higher after LPS stimulation whereas IL-29 concentrations were higher after polyIC-stimulation. AF analysis did not detect either of the cytokines either preterm or term.

Conclusion: This is the first study to report IL-24 and IL-29 expressions in human fetal membranes. Higher concentrations of these cytokines in response to distinct infectious stimuli suggest different pathways for fetal immune response during infection.

Keywords: Amniotic fluids; interleukin; polymerase chain reaction; preterm birth

About the article

Corresponding author: Ramkumar Menon, PhD The Perinatal Research Center 2300 Patterson St. Nashville TN 37203 USA Fax: +1-615-342-6541


Received: 2010-01-06

Revised: 2010-03-27

Accepted: 2010-05-01

Published Online: 2010-08-13

Published Online: 2010-08-13

Published in Print: 2010-11-01


Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm.2010.093.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
S. L. Bakaysa, J. A. Potter, M. Hoang, C. S. Han, S. Guller, E. R. Norwitz, and V. M. Abrahams
Molecular Human Reproduction, 2014, Volume 20, Number 7, Page 701
[2]
Roberto Romero, Adi L. Tarca, Piya Chaemsaithong, Jezid Miranda, Tinnakorn Chaiworapongsa, Hui Jia, Sonia S. Hassan, Cynthia A. Kalita, Juan Cai, Lami Yeo, and Leonard Lipovich
Journal of Maternal-Fetal and Neonatal Medicine, 2014, Volume 27, Number 14, Page 1397
[3]
Erin L. Whitaker, Valery A. Filippov, and Penelope J. Duerksen-Hughes
Cytokine & Growth Factor Reviews, 2012, Volume 23, Number 6, Page 323
[4]
Roberto Romero, Eleazar Soto, Stanley M. Berry, Sonia S. Hassan, Juan Pedro Kusanovic, Bo Hyun Yoon, Samuel Edwin, Moshe Mazor, and Tinnakorn Chaiworapongsa
Journal of Maternal-Fetal and Neonatal Medicine, 2012, Volume 25, Number 7, Page 1160

Comments (0)

Please log in or register to comment.
Log in